Towards a multilevel model of major depression: genes, immuno-metabolic function, and cortico-striatal signaling

[1]  B. Penninx,et al.  Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression. , 2022, Journal of affective disorders.

[2]  J. P. Hamilton,et al.  Peripheral and central kynurenine pathway abnormalities in major depression , 2022, Brain, Behavior, and Immunity.

[3]  K. Newell,et al.  Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology. , 2021, Journal of psychiatric research.

[4]  N. Nikkheslat.  Targeting inflammation in depression: Ketamine as an anti-inflammatory antidepressant in psychiatric emergency , 2021, Brain, Behavior, & Immunity - Health.

[5]  A. Strafella,et al.  Dopamine Receptors in Parkinson's Disease: A Meta‐Analysis of Imaging Studies , 2021, Movement disorders : official journal of the Movement Disorder Society.

[6]  A. Bonci,et al.  Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. , 2021, Immunity.

[7]  P. Sullivan,et al.  Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy , 2020, Molecular Psychiatry.

[8]  B. Penninx,et al.  Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression , 2020, Biological Psychiatry.

[9]  T. Dinan,et al.  Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome. , 2020, Annual review of psychology.

[10]  P. Chanson,et al.  Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case–control study , 2019, Psychiatry and clinical neurosciences.

[11]  C. Pariante,et al.  Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue , 2019, Brain, Behavior, and Immunity.

[12]  Sanjiv S Gambhir,et al.  Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation , 2018, Translational Psychiatry.

[13]  R. Marioni,et al.  Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions , 2018, Nature Neuroscience.

[14]  H. Kunugi,et al.  Cerebrospinal fluid monoamine metabolite concentrations in depressive disorder: A meta-analysis of historic evidence. , 2018, Journal of psychiatric research.

[15]  L. Tozzi,et al.  Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes , 2018, Psychoneuroendocrinology.

[16]  K. Neve,et al.  Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation , 2018, Molecular Psychiatry.

[17]  C. Martelli,et al.  Meta-analysis and review of dopamine agonists in acute episodes of mood disorder: Efficacy and safety , 2018, Journal of psychopharmacology.

[18]  H. Möller,et al.  Subtypes of depression and their overlap in a naturalistic inpatient sample of major depressive disorder , 2018, International journal of methods in psychiatric research.

[19]  Warren W. Kretzschmar,et al.  Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression , 2017, Nature Genetics.

[20]  J. Zubieta,et al.  Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response , 2017, European Neuropsychopharmacology.

[21]  A. Carvalho,et al.  Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies , 2017, Acta psychiatrica Scandinavica.

[22]  A. Danese,et al.  A bidirectional relationship between depression and the autoimmune disorders – New perspectives from the National Child Development Study , 2017, PloS one.

[23]  M. Caron,et al.  New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy , 2017, Biological Psychiatry.

[24]  Andrew T. Drysdale,et al.  Resting-state connectivity biomarkers define neurophysiological subtypes of depression , 2016, Nature Medicine.

[25]  I. Hickie,et al.  Familial aggregation and heritability of the melancholic and atypical subtypes of depression. , 2016, Journal of affective disorders.

[26]  D. Hinds,et al.  Identification of 15 genetic loci associated with risk of major depression in individuals of European descent , 2016, Nature Genetics.

[27]  Camilla L. Nord,et al.  Disrupted habenula function in major depression , 2016, Molecular Psychiatry.

[28]  Daniella J. Furman,et al.  Habenula responses to potential and actual loss in major depression: preliminary evidence for lateralized dysfunction. , 2016, Social cognitive and affective neuroscience.

[29]  C. Saper,et al.  Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. , 2016, The Journal of clinical investigation.

[30]  A. Beekman,et al.  Six-year longitudinal course and outcomes of subtypes of depression , 2016, British Journal of Psychiatry.

[31]  Andrew H. Miller,et al.  The role of inflammation in depression: from evolutionary imperative to modern treatment target , 2015, Nature Reviews Immunology.

[32]  Ellen E. Blaak,et al.  Short-chain fatty acids in control of body weight and insulin sensitivity , 2015, Nature Reviews Endocrinology.

[33]  Warren W. Kretzschmar,et al.  Sparse whole genome sequencing identifies two loci for major depressive disorder , 2015, Nature.

[34]  Teresa A. Victor,et al.  Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder , 2015, Brain, Behavior, and Immunity.

[35]  C. Conversano,et al.  Interferon α Therapy in Patients with Chronic Hepatitis C Infection: Quality of Life and Depression , 2015, Hematology reports.

[36]  R. Schubert,et al.  Lipopolysaccharide challenge: immunological effects and safety in humans , 2015, Expert review of clinical immunology.

[37]  S. Haber.  The place of dopamine in the cortico-basal ganglia circuit , 2014, Neuroscience.

[38]  O. Mors,et al.  Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. , 2014, JAMA psychiatry.

[39]  M. Kiehntopf,et al.  The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults. , 2014, The Journal of nutrition.

[40]  A. Beekman,et al.  Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression , 2013, Molecular Psychiatry.

[41]  N. Wray,et al.  A mega-analysis of genome-wide association studies for major depressive disorder , 2013, Molecular Psychiatry.

[42]  A. A. Romanovsky,et al.  Neural Circuitry Engaged by Prostaglandins during the Sickness Syndrome Nih Public Access Author Manuscript Elevated Corticosteroid Levels , 2022 .

[43]  Daniella J. Furman,et al.  Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data. , 2012, The American journal of psychiatry.

[44]  R. Schwarcz,et al.  Kynurenines in the mammalian brain: when physiology meets pathology , 2012, Nature Reviews Neuroscience.

[45]  An Pan,et al.  Bidirectional Association Between Depression and Metabolic Syndrome , 2012, Diabetes Care.

[46]  G. Guillemin.  Quinolinic acid, the inescapable neurotoxin , 2012, The FEBS journal.

[47]  Matthias J. Wieser,et al.  Why are you looking like that? How the context influences evaluation and processing of human faces , 2012, Social cognitive and affective neuroscience.

[48]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[49]  B. Bogerts,et al.  Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission? , 2011, Journal of Neuroinflammation.

[50]  J. Roiser,et al.  Habenula Volume in Bipolar Disorder and Major Depressive Disorder: A High-Resolution Magnetic Resonance Imaging Study , 2011, Biological Psychiatry.

[51]  G. Oxenkrug.  Metabolic syndrome, age‐associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism , 2010, Annals of the New York Academy of Sciences.

[52]  N. Herrmann,et al.  A Meta-Analysis of Cytokines in Major Depression , 2010, Biological Psychiatry.

[53]  V. Vaccarino,et al.  Depressive Symptoms and Metabolic Syndrome: Is Inflammation the Underlying Link? , 2008, Biological Psychiatry.

[54]  Maurizio Fava,et al.  Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. , 2008, The American journal of psychiatry.

[55]  Juha Markkula,et al.  Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET , 2008, Psychopharmacology.

[56]  J. Born,et al.  Obese men respond to cognitive but not to catabolic brain insulin signaling , 2008, International Journal of Obesity.

[57]  Philippe Mailly,et al.  Relationship between the corticostriatal terminals from areas 9 and 46, and those from area 8A, dorsal and rostral premotor cortex and area 24c: an anatomical substrate for cognition to action , 2007, The European journal of neuroscience.

[58]  Andrew J Montgomery,et al.  Extrastriatal D2 and striatal D2 receptors in depressive illness: pilot PET studies using [11C]FLB 457 and [11C]raclopride. , 2007, Journal of affective disorders.

[59]  O. Hikosaka,et al.  Lateral habenula as a source of negative reward signals in dopamine neurons , 2007, Nature.

[60]  C. Nemeroff,et al.  The role of dopamine in the pathophysiology of depression. , 2007, Archives of general psychiatry.

[61]  Alan A. Wilson,et al.  Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study. , 2006, The American journal of psychiatry.

[62]  N. Birbaumer,et al.  The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study , 2006, Proceedings of the National Academy of Sciences.

[63]  A. Bonci,et al.  The Dopamine D2 Receptor: New Surprises from an Old Friend , 2005, Neuron.

[64]  Jan Born,et al.  Intranasal insulin improves memory in humans , 2004, Psychoneuroendocrinology.

[65]  G. Reaven.  The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. , 2004, Endocrinology and metabolism clinics of North America.

[66]  J. Javitch,et al.  Mitogen-Activated Protein Kinase Regulates Dopamine Transporter Surface Expression and Dopamine Transport Capacity , 2003, The Journal of Neuroscience.

[67]  Kiyofumi Yamada,et al.  Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood–brain barrier , 2003, Brain Research.

[68]  U. Grohmann,et al.  Tolerance, DCs and tryptophan: much ado about IDO. , 2003, Trends in immunology.

[69]  S. Haber,et al.  Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[70]  R. Parsey,et al.  Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression , 2001, Biological Psychiatry.

[71]  B. Brew,et al.  Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection , 2001, Journal of neurochemistry.

[72]  P. Sullivan,et al.  Genetic epidemiology of major depression: review and meta-analysis. , 2000, The American journal of psychiatry.

[73]  Rüdiger Klein,et al.  Role of Brain Insulin Receptor in Control of Body Weight and Reproduction , 2000 .

[74]  T. Stone.  Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. , 2000, Trends in pharmacological sciences.

[75]  R. Beninger,et al.  Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: Evidence from turning behaviour and tyrosine hydroxylase immunohistochemistry , 1994, Neuroscience.

[76]  M. DiFiglia,et al.  Intrastriatal Injections of Quinolinic Acid or Kainic Acid: Differential Patterns of Cell Survival and the Effects of Data Analysis on Outcome , 1993, Experimental Neurology.

[77]  J. Kaas,et al.  Topography and collateralization of the dopaminergic projections to motor and lateral prefrontal cortex in owl monkeys , 1992, The Journal of comparative neurology.

[78]  G. E. Alexander,et al.  Functional architecture of basal ganglia circuits: neural substrates of parallel processing , 1990, Trends in Neurosciences.

[79]  T. Bonner,et al.  Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[80]  K. Wilcox,et al.  Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[81]  J. Penney,et al.  γ‐Aminobutyric Acid and Benzodiazepine Receptor Changes Induced by Unilateral 6‐Hydroxydopamine Lesions of the Medial Forebrain Bundle , 1985, Journal of neurochemistry.

[82]  K. Yoshikawa,et al.  Modulation of striatal enkephalinergic neurons by antipsychotic drugs. , 1985, Federation proceedings.

[83]  D. Lodge,et al.  The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate , 1983, British journal of pharmacology.

[84]  B. Posner,et al.  Insulin-binding sites in the rat brain: in vivo localization to the circumventricular organs by quantitative radioautography. , 1979, Endocrinology.

[85]  T. Powell,et al.  The connexions of the striatum and globus pallidus: synthesis and speculation. , 1971, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[86]  R. Marioni,et al.  Edinburgh Research Explorer Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways , 2022 .

[87]  Teresa A. Victor,et al.  Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder , 2015, Neuropsychopharmacology.

[88]  D. Begg.  Insulin transport into the brain and cerebrospinal fluid. , 2015, Vitamins and hormones.

[89]  G. Arbanas.  Diagnostic and Statistical Manual of Mental Disorders (DSM-5) , 2015 .

[90]  R. Buckner,et al.  The organization of the human striatum estimated by intrinsic functional connectivity. , 2012, Journal of neurophysiology.

[91]  R. Dantzer,et al.  From inflammation to sickness and depression: when the immune system subjugates the brain , 2008, Nature Reviews Neuroscience.

[92]  P. Schulz,et al.  Differential effects of acute and chronic administration of haloperidol on substance P and enkephalins in diverse rat brain areas. , 1986, Neuropsychobiology.

[93]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[94]  Apostolos P. Georgopoulos,et al.  Cortico-basal ganglia relations and coding of motor performance , 1983 .

[95]  A. Randrup,et al.  MENTAL AND BEHAVIOURAL STEREOTYPIES ELICITED BY STIMULANT DRUGS. RELATION TO THE DOPAMINE HYPOTHESIS OF SCHIZO-PHRENIA, MANIA AND DEPRESSION , 1981 .