Hippocampal Neurons Express GABAA Receptor Insensitive to Diazepam in Hyperexcitable Conditions

Summary: Purpose: To define the properties of γ‐aminobutyric acid‐type A (GABAA) receptors expressed on dentate granule cells in neonatal rats and to define the impact of prolonged seizures on GABAA receptors in 28‐ to 35‐day‐old rats.

[1]  R. Macdonald,et al.  Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties. , 1999, Molecular pharmacology.

[2]  D. Coulter,et al.  Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy , 1998, Nature Medicine.

[3]  G. Sperk,et al.  Expression of GABAA receptor subunits in the hippocampus of the rat after kainic acid-induced seizures , 1998, Epilepsy Research.

[4]  S. Smith,et al.  GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid. , 1998, Nature.

[5]  P. Klein,et al.  Hormonal Effects on Epilepsy in Women , 1998, Epilepsia.

[6]  C. Frye,et al.  Withdrawal from 3α-OH-5α-Pregnan-20-One Using a Pseudopregnancy Model Alters the Kinetics of Hippocampal GABAA-Gated Current and Increases the GABAAReceptor α4 Subunit in Association with Increased Anxiety , 1998, The Journal of Neuroscience.

[7]  F. Hsu,et al.  GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid , 1998, Nature.

[8]  C. Frye,et al.  Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety. , 1998, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[9]  R. Macdonald,et al.  Rapid Seizure-Induced Reduction of Benzodiazepine and Zn2+ Sensitivity of Hippocampal Dentate Granule Cell GABAA Receptors , 1997, The Journal of Neuroscience.

[10]  R. Olsen,et al.  Chronic Intermittent Ethanol Treatment in Rats Increases GABAA Receptor α4‐Subunit Expression: Possible Relevance to Alcohol Dependence , 1997, Journal of neurochemistry.

[11]  Yufei Wang,et al.  Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. , 1996, Molecular pharmacology.

[12]  R. Macdonald,et al.  Cyclic AMP-dependent protein kinase enhances hippocampal dentate granule cell GABAA receptor currents. , 1996, Journal of neurophysiology.

[13]  J. Sikela,et al.  Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. , 1996, Molecular pharmacology.

[14]  R. Macdonald,et al.  Pharmacological properties of gamma-aminobutyric acidA receptors from acutely dissociated rat dentate granule cells. , 1996, Molecular pharmacology.

[15]  R. Macdonald,et al.  Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms. , 1996, Molecular pharmacology.

[16]  I. Módy,et al.  Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model , 1996, Science.

[17]  Y. Ozoe GABA A Receptor Channels , 1996 .

[18]  Virginia Bottomley,et al.  Messages of Support , 1995 .

[19]  R. Macdonald GABAalpha Receptor Channels , 1994 .

[20]  K. Kelly,et al.  Antiepileptic Drug Mechanisms of Action , 1993, Epilepsia.

[21]  B. Sakmann,et al.  Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+ , 1990, Neuron.

[22]  M. Ticku,et al.  Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons. , 1989, The Journal of pharmacology and experimental therapeutics.

[23]  M. Ticku,et al.  Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain. , 1988, European journal of pharmacology.

[24]  Robert K. S. Wong,et al.  Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems , 1986, Journal of Neuroscience Methods.

[25]  W. Sieghart,et al.  Irreversible Binding of [3H]Flunitrazepam to Different Proteins in Various Brain Regions , 1983, Journal of neurochemistry.