THE EFFECT OF IODO‐DEOXYURIDINE ON HERPES SIMPLEX VIRUS ENCEPHALITIS IN ANIMALS AND MAN

Following Kaufmann's original work on herpetic infections in rabbit eyes many clinical t r ia ls have indicated the value of iododeoxyuridine (IUdR) in the treatment of eye infections and recently its use has been critically assessed. dimethyl sulphoxide promotes the healing of experimental cutaneous herpes in animals and of the recurrent herpes labialis in man. 3, Early reports5> 6*-7 on the use of iodo-deoxyuridine in the treatment of herpetic infections of the brain, raised hopes that the drug might also provide effective therapy for this serious condition. Although herpes encephalitis is a comparatively r a r e condition, the application of chemotherapy i s worth consideration, f irst ly to improve, i f possible, the prognosis in a very grave illness, and secondly to determine the effect on a deep infection of a drug known to be effective against superficial infections. In an attempt to assess the effect of IUdR on brain infections we report some clinical observations and the results of some animal experiments. The drug dissolved in

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