The effect of T1-relaxation on tensor-derived ADC-maps

2 , gradient directions (1 0 0, 0.446 0.895 0, 0.447 0.275 0.851, 0.448 -0.723 -0.525, 0.447 -0.724 0.526, -0.449 -0.277 0.85)) was performed using a standard clinical protocol (matrix 128x128, FOV=25.6 cm, TE=82.6 ms, TR=5 s). Twice-refocused, interleaved SS-EPI was used to collect the maximum number of slices (thk 2.5 mm) allowed. The DTI experiment were repeated 4 times with an inter-scan time interval of 30 s, mimicking a clinical situation and allowing for full T1-recovery. FSL (www.fmrib.ox.ac.uk/fsl, ver 4.0) was used for distortion-corrected and realignment and creation of binary brain masks. The S0:s were used individually with the set of S(r):s to create 8 seperate 1S0+6S(r) datasets Si. Matlab (MathWorks, Natik, MA) was used for repetition bootstrapping on each Si and voxelwise tensors Di were estimated for each bootstrap (using www.mathworks.com/matlabcentral/fileexchange/21130-dti-and-fiber-tracking). ADCi = trace(Di)/3 were then calculated for every tensor Di in every dataset Si.