Percutaneous penetration of some pesticides and herbicides in man.

Twelve radiolabeled 14C-pesticides and herbicides were applied to the forearms of human subjects, and the urinary excretion of 14C was quantitated. Data obtained after iv dosing was used to correct the skin penetration data for incomplete urinary recovery. The data indicate that all the pesticides and herbicides tested are absorbed. The least absorbed was diquat, and the greatest absorption was found with carbaryl.

[1]  H. Maibach,et al.  THE EFFECT OF DMSO ON PERCUTANEOUS PENETRATION OF HYDROCORTISONE AND TESTOSTERONE IN MAN * , 1967, Annals of the New York Academy of Sciences.

[2]  H R Wolfe,et al.  Exposure of workers to pesticides. , 1967, Archives of environmental health.

[3]  H. Maibach,et al.  Percutaneous penetration of steroids in man. , 1969, The Journal of investigative dermatology.

[4]  Maibach Hi,et al.  Regional variation in percutaneous penetration in man. Pesticides. , 1971 .

[5]  H. Maibach,et al.  Regional variation in percutaneous penetration of 14C cortisol in man. , 1967, The Journal of investigative dermatology.

[6]  G. Simpson.  EXPOSURE TO ORCHARD PESTICIDES: DERMAL AND INHALATION EXPOSURES. , 1965, Archives of environmental health.

[7]  S. V. Eicken.  Zur Ausscheidung von p-Nitrophenol im Urin nach Einwirkung von Pflanzenschutzmittel „E 605” , 1954 .

[8]  H. Maibach,et al.  Absorption of some organic compounds through the skin in man. , 1970, The Journal of investigative dermatology.

[9]  W. F. Durham.  PESTICIDE EXPOSURE LEVELS IN MAN AND ANIMALS. , 1965, Archives of environmental health.

[10]  H. Maibach,et al.  Percutaneous penetration of 14C hydrocortisone in man. II. Effect of certain bases and pretreatments. , 1966, Archives of dermatology.

[11]  Hayes Gr,et al.  DERMAL EXPOSURE OF HUMAN VOLUNTEERS TO PARATHION. , 1964 .

[12]  W. F. Durham,et al.  Pesticide exposure from concentrate spraying. , 1966, Archives of environmental health.