Elevated ratio of summed serum proinsulin to insulin response after oral glucose load in type 2 diabetes decreases following sulfonylurea treatment.

[1]  M. Davies,et al.  Effect of Sulphonylurea Therapy on Plasma Insulin, Intact and 32/33 Split Proinsulin in Subjects with Type 2 Diabetes Mellitus , 1994, Diabetic medicine : a journal of the British Diabetic Association.

[2]  J. Leahy,et al.  Relative Hypersecretion of Proinsulin in Rat Model of NIDDM , 1991, Diabetes.

[3]  P. Bennett,et al.  Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus. , 1990, The Journal of clinical endocrinology and metabolism.

[4]  S. Kahn,et al.  Hyperproinsulinemia and Amyloid in NIDDM: Clues to Etiology of Islet β-Cell Dysfunction? , 1989, Diabetes.

[5]  D. Owens,et al.  Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. , 1989, The Biochemical journal.

[6]  R. Bergman,et al.  Increased β-Cell Secretory Capacity as Mechanism for Islet Adaptation to Nicotinic Acid-Induced Insulin Resistance , 1989, Diabetes.

[7]  Y. Iwamoto,et al.  Effects of Dietary Treatment on Serum Insulin and Proinsulin Response in Newly Diagnosed NIDDM , 1989, Diabetes.

[8]  M. Ballmann,et al.  Preferential release of proinsulin relative to insulin in non-insulin-dependent diabetes mellitus. , 1988, Acta endocrinologica.

[9]  H. Yki-Järvinen,et al.  The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma. , 1986, The Journal of clinical endocrinology and metabolism.

[10]  K. Polonsky,et al.  The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes. , 1984, The Journal of clinical endocrinology and metabolism.

[11]  A. Rubenstein,et al.  Circulating proinsulin in patients with maturity onset diabetes. , 1977, The American journal of medicine.

[12]  E. Pfeiffer,et al.  (Pro‐)Insulin Biosynthesis and Release of Newly Synthesized (Pro‐)Insulin from Isolated Islets of Rat Pancreas in the Presence of Amino Acids and Sulphonylureas +, ++ , 1975, European journal of clinical investigation.

[13]  A. Katz,et al.  Metabolism of proinsulin, insulin, and C-peptide in the rat. , 1973, The Journal of clinical investigation.

[14]  D. Steiner,et al.  The metabolism of proinsulin and insulin by the liver. , 1972, The Journal of clinical investigation.