Genes coding for Shiga-like toxin and heat-stabile enterotoxin in porcine strains of Escherichia coli.

Besides diarrheagenic enterotoxigenic Escherichia coli (ETEC) that produce classical heat stable and/or heat labile enterotoxins (STs, LTs) and the class of Shiga-like toxin-producing entero-hemorrhagic E. coli (EHEC), a new category of E. coli is defined sharing similarities with ETEC and EHEC. DNA hybridization studies indicate that some E. coli serovars from porcine origin harbor genes encoding cytotonic ST and cytotoxic Shiga-like toxin. The presence of two potent toxins might contribute to the virulence of such strains and should be taken into consideration when bio-assays are performed.

[1]  H. Karch,et al.  Synthetic oligodeoxyribonucleotide probes to detect verocytotoxin-producing Escherichia coli in diseased pigs. , 1989, FEMS microbiology letters.

[2]  M. P. Jackson,et al.  Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine , 1988, Journal of bacteriology.

[3]  H. Karch,et al.  Purified verotoxins of Escherichia coli O157:H7 decrease prostacyclin synthesis by endothelial cells. , 1988, Microbial pathogenesis.

[4]  R. Edelman,et al.  Summary of the International Symposium and Workshop on infections due to verocytotoxin (Shiga-like toxin)-producing Escherichia coli) , 1988 .

[5]  M. Nishibuchi,et al.  Evaluation of a nonisotopically labeled oligonucleotide probe to detect the heat-stable enterotoxin gene of Escherichia coli by the DNA colony hybridization test , 1988, Journal of clinical microbiology.

[6]  M. P. Jackson,et al.  Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages from Escherichia coli 933 , 1987 .

[7]  J. Peiris,et al.  Escherichia coli strains isolated from pigs with edema disease produce a variant of Shiga-like toxin II , 1987 .

[8]  S. Climie,et al.  Nucleotide sequence and promoter mapping of the Escherichia coli Shiga-like toxin operon of bacteriophage H-19B , 1987, Journal of bacteriology.

[9]  H. Karch,et al.  Phage-associated cytotoxin production by and enteroadhesiveness of enteropathogenic Escherichia coli isolated from infants with diarrhea in West Germany. , 1987, The Journal of infectious diseases.

[10]  H. Karch,et al.  Growth of Escherichia coli in the presence of trimethoprim-sulfamethoxazole facilitates detection of Shiga-like toxin producing strains by colony blot assay , 1986 .

[11]  R. Holmes,et al.  Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities , 1986, Infection and immunity.

[12]  K. C. Reed,et al.  Rapid transfer of DNA from agarose gels to nylon membranes. , 1985, Nucleic acids research.

[13]  H. Smith,et al.  Vero cell toxins in Escherichia coli and related bacteria: transfer by phage and conjugation and toxic action in laboratory animals, chickens and pigs. , 1983, Journal of general microbiology.

[14]  M. Thompson,et al.  Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli. , 1982, The Journal of infectious diseases.

[15]  R. Lathe,et al.  Cell-free synthesis of enterotoxin of E. coli from a cloned gene , 1980, Nature.

[16]  J Konowalchuk,et al.  Vero response to a cytotoxin of Escherichia coli , 1977, Infection and immunity.

[17]  S. Falkow,et al.  Plasmid-mediated properties of a heat-stable enterotoxin-producing Escherichia coli associated with infantile diarrhea , 1976, Infection and immunity.