Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
暂无分享,去创建一个
[1] J. Houston,et al. Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats. , 1990, Biochemical pharmacology.
[2] J B Houston,et al. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. , 1994, Biochemical pharmacology.
[3] D. Friend,et al. HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS , 1969, The Journal of cell biology.
[4] Yuichi Sugiyama,et al. Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro. , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[5] F. Oesch,et al. Drug metabolizing capacity of cryopreserved human, rat, and mouse liver parenchymal cells in suspension. , 1999, Drug Metabolism And Disposition.
[6] J B Houston,et al. Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices. , 1997, Drug metabolism reviews.
[7] D. Jack. Handbook of Clinical Pharmacokinetic Data , 1992, Palgrave Macmillan UK.
[8] Masato Chiba,et al. Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[9] Yau Yi Lau,et al. Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[10] H. Thijssen,et al. Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4'-nitrowarfarin (acenocoumarol). , 1991, Xenobiotica; the fate of foreign compounds in biological systems.
[11] A. Yacobi,et al. Protein binding of warfarin enantiomers in serum of humans and rats , 1977, Journal of Pharmacokinetics and Biopharmaceutics.
[12] P Skett,et al. Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-Solutions? , 1994, Toxicology in vitro : an international journal published in association with BIBRA.
[13] J. Houston,et al. Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data. , 1995, The Journal of pharmacology and experimental therapeutics.
[14] G. J. Conard,et al. Binding of 5,5-diphenylhydantoin and its major metabolite to human and rat plasma proteins. , 1971, Journal of pharmaceutical sciences.
[15] A. Li,et al. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. , 1999, Chemico-biological interactions.
[16] J. Houston,et al. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat. , 1999, The Journal of pharmacology and experimental therapeutics.
[17] J. Villeneuve,et al. Propranolol disposition in the rat: variation in hepatic extraction with unbound drug fraction. , 1992, Journal of pharmaceutical sciences.
[18] J. Houston,et al. In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[19] R. Branch,et al. Intact hepatocyte theory of impaired drug metabolism in experimental cirrhosis in the rat. , 1979, Gastroenterology.
[20] B. Burchell,et al. In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance. , 2002, The Journal of pharmacology and experimental therapeutics.
[21] J. Houston,et al. Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance. , 1995, Xenobiotica; the fate of foreign compounds in biological systems.
[22] K H Antonin,et al. Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat. , 1976, The Journal of pharmacology and experimental therapeutics.
[23] J B Houston,et al. In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model. , 2000, Drug metabolism and disposition: the biological fate of chemicals.