Osteoarthritis: pathogenic signaling pathways and therapeutic targets
暂无分享,去创建一个
G. Xiao | Sheng Chen | Mingjue Chen | Xiaohao Wu | Chu Tao | Tailin He | Minghao Qu | Yiming Zhong | Q. Yao | Weiyuan Gong
[1] Sara F. Saadawy,et al. Breast milk mesenchymal stem cells abate cisplatin-induced cardiotoxicity in adult male albino rats via modulating the AMPK pathway , 2022, Scientific Reports.
[2] Omnia Ameen,et al. Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway , 2022, Scientific Reports.
[3] Zhenhan Deng,et al. Metformin Prevents or Delays the Development and Progression of Osteoarthritis: New Insight and Mechanism of Action , 2022, Cells.
[4] G. Xiao,et al. Current understanding of osteoarthritis pathogenesis and relevant new approaches , 2022, Bone Research.
[5] Bo Qiu,et al. Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes. , 2022, Biochemical and biophysical research communications.
[6] Ziyi Wu,et al. The effects of metformin in the treatment of osteoarthritis: Current perspectives , 2022, Frontiers in Pharmacology.
[7] J. Gimble,et al. Non-homologous use of adipose-derived cell and tissue therapies: Osteoarthritis as a case study , 2022, Bone reports.
[8] G. Xiao,et al. Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice , 2022, International journal of oral science.
[9] R. Crawford,et al. Obesity, Inflammation, and Immune System in Osteoarthritis , 2022, Frontiers in Immunology.
[10] J. Biernaskie,et al. Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration , 2022, npj Regenerative Medicine.
[11] Wen-qing Xie,et al. Progress in osteoarthritis research by the National Natural Science Foundation of China , 2022, Bone Research.
[12] J. Loughlin,et al. Genetics of osteoarthritis , 2022, Osteoarthritis and Cartilage.
[13] M. J. Wood,et al. The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain. , 2022, Clinics in geriatric medicine.
[14] Huan Yu,et al. Osteoarthritis Pain , 2022, International journal of molecular sciences.
[15] Xuan Zhang,et al. Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis , 2022, Diabetes, metabolic syndrome and obesity : targets and therapy.
[16] J. Bilal,et al. Tanezumab for the treatment of osteoarthritis pain. , 2022, Drugs of today.
[17] Nianfei Zhang,et al. Alterations of the Subchondral Bone in Osteoarthritis: Complying with Wolff's law. , 2022, Current rheumatology reviews.
[18] A. Guermazi,et al. Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study , 2022, Arthritis Research & Therapy.
[19] S. Bierma-Zeinstra,et al. Estimating incidence and prevalence of hip osteoarthritis using electronic health records: a population-based cohort study. , 2022, Osteoarthritis and cartilage.
[20] A. Shpichka,et al. Gender-Related Aspects in Osteoarthritis Development and Progression: A Review , 2022, International journal of molecular sciences.
[21] Qiang Liu,et al. Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019 , 2022, Arthritis & rheumatology.
[22] Ti Zheng,et al. Exosomes Derived From miR-212-5p Overexpressed Human Synovial Mesenchymal Stem Cells Suppress Chondrocyte Degeneration and Inflammation by Targeting ELF3 , 2022, Frontiers in Bioengineering and Biotechnology.
[23] Huiling Cao,et al. Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice , 2022, Nature communications.
[24] Jiantao Zhang,et al. Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats , 2022, Frontiers in Pharmacology.
[25] Yoorim Choi,et al. Correction: TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis , 2022, Cell death and differentiation.
[26] Y. Alippe,et al. IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology , 2022, Bone Research.
[27] N. Itoh,et al. New developments in the biology of fibroblast growth factors. , 2022, WIREs mechanisms of disease.
[28] F. Berenbaum,et al. Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes , 2022, International journal of molecular sciences.
[29] Huiling Cao,et al. Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc , 2022, Bone Research.
[30] J. Harlaar,et al. Osteoarthritis year in review 2021: mechanics. , 2022, Osteoarthritis and cartilage.
[31] J. Loughlin. Translating osteoarthritis genetics research: challenging times ahead. , 2022, Trends in molecular medicine.
[32] Song Ho Chang,et al. Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development , 2021, Nature Communications.
[33] Dan Yi,et al. Molecular signaling in temporomandibular joint osteoarthritis , 2021, Journal of orthopaedic translation.
[34] G. Xiao,et al. Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice , 2021, Journal of orthopaedic translation.
[35] Yang-Yang Bian,et al. Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis , 2022, Frontiers in Cell and Developmental Biology.
[36] Z. Zuo,et al. Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder , 2021, Redox biology.
[37] J. Block. Are Intraarticular Glucocorticoids Safe in Osteoarthritis? , 2021, Arthritis & rheumatology.
[38] J. Katz,et al. Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis. , 2021, JAMA.
[39] J. Marzo,et al. Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling , 2021, Arthritis Research & Therapy.
[40] Win Min Oo,et al. Nerve Growth Factor (NGF) Inhibitors and Related Agents for Chronic Musculoskeletal Pain: A Comprehensive Review , 2021, BioDrugs.
[41] J. Soul,et al. Osteoarthritis year in review: genetics, genomics, epigenetics , 2021, Osteoarthritis and cartilage.
[42] W. Richter,et al. MiR-181a Targets RSPO2 and Regulates Bone Morphogenetic Protein – WNT Signaling Crosstalk During Chondrogenic Differentiation of Mesenchymal Stromal Cells , 2021, Frontiers in Cell and Developmental Biology.
[43] S. Bierma-Zeinstra,et al. Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis: A Randomized Clinical Trial. , 2021, JAMA.
[44] Huiling Cao,et al. Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues , 2021, Bone Research.
[45] Lin Chen,et al. Long term usage of dexamethasone accelerating the initiation of osteoarthritis via enhancing the extracellular matrix calcification and apoptosis of chondrocytes , 2021, International journal of biological sciences.
[46] Liao Wang,et al. Abnormal Subchondral Trabecular Bone Remodeling in Knee Osteoarthritis under the Influence of Knee Alignment. , 2021, Osteoarthritis and cartilage.
[47] G. Peat,et al. Osteoarthritis year in review 2021: epidemiology & therapy. , 2021, Osteoarthritis and cartilage.
[48] G. Nalesso,et al. WNT Signalling in Osteoarthritis and Its Pharmacological Targeting. , 2021, Handbook of experimental pharmacology.
[49] Yuan Zhang,et al. Neuromedin B receptor stimulation of Cav3.2 T-type Ca2+ channels in primary sensory neurons mediates peripheral pain hypersensitivity , 2021, Theranostics.
[50] L. O. Dantas,et al. Therapeutic ultrasound for knee osteoarthritis: A systematic review and meta-analysis with grade quality assessment. , 2021, Brazilian journal of physical therapy.
[51] W. R. Thompson,et al. Systemic Inhibition or Global Deletion of CaMKK2 Protects Against Post-Traumatic Osteoarthritis. , 2021, Osteoarthritis and cartilage.
[52] Libo Jiang,et al. Hypoxia Inducible Factor-1α Is a Regulator of Autophagy in Osteoarthritic Chondrocytes , 2021, Cartilage.
[53] P. Leng,et al. G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1 , 2021, Molecular medicine.
[54] Tom R. Gaunt,et al. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations , 2021, Cell.
[55] G. Xiao,et al. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis , 2021, Nature Aging.
[56] Huiling Cao,et al. Pinch Loss Ameliorates Obesity, Glucose Intolerance, and Fatty Liver by Modulating Adipocyte Apoptosis in Mice , 2021, Diabetes.
[57] Wen Li,et al. Role of HIF-2α/NF-κB pathway in mechanical stress-induced temporomandibular joint osteoarthritis. , 2021, Oral diseases.
[58] Yonghua Hu,et al. Trends and Patterns of Knee Osteoarthritis in China: A Longitudinal Study of 17.7 Million Adults from 2008 to 2017 , 2021, International journal of environmental research and public health.
[59] P. Mantyh,et al. Treating osteoarthritis pain: mechanisms of action of acetaminophen, nonsteroidal anti-inflammatory drugs, opioids, and nerve growth factor antibodies , 2021, Postgraduate medicine.
[60] M. Fini,et al. Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data , 2021, Journal of clinical medicine.
[61] Wei Wang,et al. Sex Steroids and Osteoarthritis: A Mendelian Randomization Study , 2021, Frontiers in Endocrinology.
[62] C. Xue,et al. A low proportion n-6/n-3 PUFA diet supplemented with Antarctic krill (Euphausia superba) oil protects against osteoarthritis by attenuating inflammation in ovariectomized mice. , 2021, Food & function.
[63] Yi Zhang,et al. Mechanistic Insight Into the Roles of Integrins in Osteoarthritis , 2021, Frontiers in Cell and Developmental Biology.
[64] E. Hagert,et al. Cartilage Injuries and Posttraumatic Osteoarthritis in the Wrist: A Review , 2021, Cartilage.
[65] C. Hilkens,et al. Synovial Macrophages in Osteoarthritis: The Key to Understanding Pathogenesis? , 2021, Frontiers in Immunology.
[66] M. Kapoor,et al. Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis , 2021, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
[67] L. Deng,et al. Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation , 2021, Journal of cellular and molecular medicine.
[68] Richard J. Miller,et al. Basic Mechanisms of Pain in Osteoarthritis: Experimental Observations and New Perspectives. , 2021, Rheumatic diseases clinics of North America.
[69] Tengyun Yang,et al. Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis , 2021, Human Genomics.
[70] Tao Xu,et al. Moderate mechanical stress suppresses the IL‐1β‐induced chondrocyte apoptosis by regulating mitochondrial dynamics , 2021, Journal of cellular physiology.
[71] Ge Zhang,et al. Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression , 2021, Nature Aging.
[72] Y. Liu,et al. Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/-catenin pathway , 2021, Stem Cell Research & Therapy.
[73] P. Emans,et al. Discovery of bone morphogenetic protein 7-derived peptide sequences that attenuate the human osteoarthritic chondrocyte phenotype , 2021, Molecular therapy. Methods & clinical development.
[74] X. Guo,et al. Mechanical stress determines the configuration of TGFβ activation in articular cartilage , 2021, Nature Communications.
[75] Jiacan Su,et al. Subchondral bone microenvironment in osteoarthritis and pain , 2021, Bone Research.
[76] Xinzhong Dong,et al. Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice , 2021, eLife.
[77] H. Min,et al. Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy–Lysosomal Pathway , 2021, Cells.
[78] J. Katz,et al. Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. , 2021, JAMA.
[79] W. Xue,et al. Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects , 2021, Drug design, development and therapy.
[80] J. Andrawis,et al. Comparison of an Artificial Intelligence–Enabled Patient Decision Aid vs Educational Material on Decision Quality, Shared Decision-Making, Patient Experience, and Functional Outcomes in Adults With Knee Osteoarthritis , 2021, JAMA network open.
[81] C. Deroyer,et al. Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381–397 a.a.) competing for TGF-β1 activation , 2021, Experimental & Molecular Medicine.
[82] Tianyan You,et al. Phospholipase A2 inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression , 2021, Science Advances.
[83] L. Bai,et al. JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy , 2021, Aging cell.
[84] L. Levin,et al. Targeting cartilage EGFR pathway for osteoarthritis treatment , 2021, Science Translational Medicine.
[85] D. Kobsar,et al. Osteoarthritis year in review 2020: Mechanics. , 2021, Osteoarthritis and cartilage.
[86] Hailang Sun,et al. Circ_0045714 alleviates TNF-α-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis , 2021, Journal of Bioenergetics and Biomembranes.
[87] Jun Zou,et al. Targeted treatment for osteoarthritis: drugs and delivery system , 2021, Drug delivery.
[88] A. Mobasheri,et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis , 2020, Ageing Research Reviews.
[89] T. Mckeown. Mechanics , 1970, The Mathematics of Fluid Flow Through Porous Media.
[90] G. Zhai. Clinical relevance of biochemical and metabolic changes in osteoarthritis. , 2021, Advances in clinical chemistry.
[91] C. Baerwald,et al. Interaction of pain and chronic inflammation , 2020, Zeitschrift für Rheumatologie.
[92] M. Laitner,et al. Understanding the Impact of Sex and Gender in Osteoarthritis: Assessing Research Gaps and Unmet Needs. , 2020, Journal of women's health.
[93] S. Nehrer,et al. Mesenchymal Stromal Cell-Derived Extracellular Vesicles – Silver Linings for Cartilage Regeneration? , 2020, Frontiers in Cell and Developmental Biology.
[94] Huiling Cao,et al. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice , 2020, Signal Transduction and Targeted Therapy.
[95] M. Kapoor,et al. Year In Review: Genetics, Genomics, Epigenetics. , 2020, Osteoarthritis and cartilage.
[96] N. Lane,et al. The evolution of nerve growth factor inhibition in clinical medicine , 2020, Nature Reviews Rheumatology.
[97] R. Loeser,et al. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis , 2020, Nature Reviews Rheumatology.
[98] F. Berenbaum,et al. Role of adipose tissues in osteoarthritis , 2020, Current opinion in rheumatology.
[99] N. Zhang,et al. Efficacy of Intensive Acupuncture Versus Sham Acupuncture in Knee Osteoarthritis: A Randomized Controlled Trial , 2020, Arthritis & rheumatology.
[100] S. Dong,et al. Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis , 2020, Annals of the Rheumatic Diseases.
[101] M. Hagen,et al. Pain characteristics and biomarkers in treatment approaches for osteoarthritis pain. , 2020, Pain management.
[102] H. Kwon,et al. Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein , 2020, Autophagy.
[103] Raveendhara R. Bannuru,et al. Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines , 2020, Nature Reviews Rheumatology.
[104] Jun Lu,et al. Precise targeting of miR-141/200c cluster in chondrocytes attenuates osteoarthritis development , 2020, Annals of the Rheumatic Diseases.
[105] Nanwei Xu,et al. Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis , 2020, Aging.
[106] Diane Flynn,et al. Chronic Musculoskeletal Pain: Nonpharmacologic, Noninvasive Treatments. , 2020, American family physician.
[107] Huiling Cao,et al. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice , 2020, Bone Research.
[108] Eun Sug Park,et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 , 2020, Lancet.
[109] S. Ravalli,et al. Apoptosis and Autophagy in the Pathogenesis of Osteoarthritis , 2020, Journal of investigative surgery : the official journal of the Academy of Surgical Research.
[110] Yunliang Guo,et al. CCAL1 enhances osteoarthritis through the NF‐κB/AMPK signaling pathway , 2020, FEBS open bio.
[111] D. Fliser,et al. WNT–β-catenin signalling — a versatile player in kidney injury and repair , 2020, Nature Reviews Nephrology.
[112] Jiazhu Tang,et al. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis , 2020, Journal of Orthopaedic Surgery and Research.
[113] T. Vincent. Peripheral pain mechanisms in osteoarthritis , 2020, Pain.
[114] Kang Xu,et al. Safflower yellow alleviates osteoarthritis and prevents inflammation by inhibiting PGE2 release and regulating NF-κB/SIRT1/AMPK signaling pathways. , 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[115] E. Schipani,et al. In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes. , 2020, Bone.
[116] Yueqi Zhang,et al. Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model , 2020, Frontiers in Pharmacology.
[117] Lidong Wu,et al. Wnt/β-catenin signaling may induce senescence of chondrocytes in osteoarthritis , 2020, Experimental and therapeutic medicine.
[118] Jonghoon Choi,et al. Mesenchymal Stem Cell‐Derived Exosomes for Effective Cartilage Tissue Repair and Treatment of Osteoarthritis , 2020, Biotechnology journal.
[119] K. Tanimoto,et al. FAK inhibition protects condylar cartilage under excessive mechanical stress. , 2020, Oral diseases.
[120] A. Mobasheri,et al. Dickkopf-3 (DKK3) Signaling in IL-1α-Challenged Chondrocytes: Involvement of the NF-κB Pathway , 2020, Cartilage.
[121] Jinmin Zhao,et al. pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis , 2020, Journal of Nanobiotechnology.
[122] Huiling Cao,et al. Molecular mechanosensors in osteocytes , 2020, Bone Research.
[123] Charles A. Harris,et al. Adipose tissue is a critical regulator of osteoarthritis , 2020, Proceedings of the National Academy of Sciences.
[124] Yao Li,et al. Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy , 2020, Cell Death & Disease.
[125] Lingyun Sun,et al. Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017 , 2020, Annals of the Rheumatic Diseases.
[126] L. Chan,et al. A Systematic Review of the Incidence, Prevalence, Costs, and Activity/Work Limitations of Amputation, Osteoarthritis, Rheumatoid Arthritis, Back Pain, Multiple Sclerosis, Spinal Cord Injury, Stroke, and Traumatic Brain Injury in the United States: A 2019 Update. , 2020, Archives of physical medicine and rehabilitation.
[127] Kaiqun Li,et al. Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis , 2020, Journal of cellular physiology.
[128] Xiu Cheng,et al. Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF-кB pathway , 2020, Inflammation Research.
[129] J. Dragoo,et al. Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials , 2020, The American journal of sports medicine.
[130] Yan Bian,et al. Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis , 2020, Cell cycle.
[131] D. Rhon,et al. Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. , 2020, The New England journal of medicine.
[132] Shan-Chi Liu,et al. Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis , 2020, Cells.
[133] C. Coupland,et al. Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD). , 2020, Osteoarthritis and cartilage.
[134] R. Liu-Bryan,et al. Metformin limits osteoarthritis development and progression through activation of AMPK signalling , 2020, Annals of the Rheumatic Diseases.
[135] Huiling Cao,et al. Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells , 2020, Frontiers in Cell and Developmental Biology.
[136] T. Vos,et al. Burden of osteoarthritis in China, 1990-2017: findings from the Global Burden of Disease Study 2017. , 2020, The Lancet. Rheumatology.
[137] B. Abramoff,et al. Osteoarthritis: Pathology, Diagnosis, and Treatment Options. , 2020, The Medical clinics of North America.
[138] Y. Boirie,et al. Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis , 2020, Scientific Reports.
[139] Guodong Wang,et al. miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1α) , 2020, Medical science monitor : international medical journal of experimental and clinical research.
[140] Huiling Cao,et al. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice , 2020, Nature Communications.
[141] G. Xiao,et al. Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR , 2020, Aging.
[142] G. Guyatt,et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee , 2020, Arthritis care & research.
[143] Di Chen,et al. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice , 2020, Bone Research.
[144] Jian-Feng Tu,et al. Effect of Electro-Acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in Knee Osteoarthritis , 2019, Journal of pain research.
[145] R. O’Keefe,et al. Runx2 plays a central role in Osteoarthritis development , 2019, Journal of orthopaedic translation.
[146] G. Collins,et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017 , 2019, Annals of the Rheumatic Diseases.
[147] Deye Song,et al. AMPK: implications in osteoarthritis and therapeutic targets. , 2020, American journal of translational research.
[148] S. Larsson. with at a Mendelian randomization study. , 2020 .
[149] Yongchun Zhang,et al. BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract. , 2020, Annual review of physiology.
[150] Huan Yu,et al. Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes. , 2020, Journal of ethnopharmacology.
[151] D. Hunter,et al. Stem cell‐directed therapies for osteoarthritis: The promise and the practice , 2019, Stem cells.
[152] Wei Li,et al. Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[153] Yuquan Shi,et al. Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK/mTOR signaling pathway. , 2019, Biochemistry and cell biology = Biochimie et biologie cellulaire.
[154] Qian Chen,et al. Adipokines: New Therapeutic Target for Osteoarthritis? , 2019, Current Rheumatology Reports.
[155] Hengjin Dong,et al. Osteoarthritis in the Middle-Aged and Elderly in China: Prevalence and Influencing Factors , 2019, International journal of environmental research and public health.
[156] A. Grodzinsky,et al. DEXAMETHASONE: CHONDROPROTECTIVE CORTICOSTEROID OR CATABOLIC KILLER? , 2019, European cells & materials.
[157] Di Chen,et al. Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. , 2019, JCI insight.
[158] Song Ho Chang,et al. Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5 , 2019, Scientific Reports.
[159] Felix Eckstein,et al. Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial. , 2019, JAMA.
[160] R. Pașca,et al. Systemic drugs with impact on osteoarthritis , 2019, Drug metabolism reviews.
[161] Liu Pengcheng,et al. Quercetin attenuates oxidative stress‐induced apoptosis via SIRT1/AMPK‐mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model , 2019, Journal of cellular physiology.
[162] I. Weissman,et al. Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. , 2019, JCI insight.
[163] E. Roos,et al. Physical therapy for patients with knee and hip osteoarthritis: supervised, active treatment is current best practice. , 2019, Clinical and experimental rheumatology.
[164] E. Hinoi,et al. Postnatal Runx2 deletion leads to low bone mass and adipocyte accumulation in mice bone tissues. , 2019, Biochemical and biophysical research communications.
[165] John P. Ketz,et al. Chondrocyte‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice , 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[166] B. Melchior,et al. Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment. , 2019, Osteoarthritis and cartilage.
[167] S. Goh,et al. Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis , 2019, Annals of physical and rehabilitation medicine.
[168] M. Schiltenwolf,et al. Synovial Cytokines Significantly Correlate with Osteoarthritis-Related Knee Pain and Disability: Inflammatory Mediators of Potential Clinical Relevance , 2019, Journal of clinical medicine.
[169] X. Yang,et al. MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling , 2019, Aging.
[170] anonymous,et al. Comprehensive review , 2019 .
[171] P. M. van der Kraan,et al. TGFβ/BMP Signaling Pathway in Cartilage Homeostasis , 2019, Cells.
[172] G. R. Dodge,et al. Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage. , 2019, European cells & materials.
[173] Robert N. Taylor,et al. Assessing research gaps and unmet needs in endometriosis. , 2019, American journal of obstetrics and gynecology.
[174] K. Lyons,et al. The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage , 2019, Proceedings of the National Academy of Sciences.
[175] Wei Yang,et al. Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2. , 2019, JCI insight.
[176] Qing Jiang,et al. Estrogen prevents articular cartilage destruction in a mouse model of AMPK deficiency via ERK-mTOR pathway. , 2019, Annals of translational medicine.
[177] S. Lord,et al. Risk factors for falls in patients with total hip arthroplasty and total knee arthroplasty: a systematic review and meta-analysis. , 2019, Osteoarthritis and cartilage.
[178] I. Chiu,et al. Pain and immunity: implications for host defence , 2019, Nature Reviews Immunology.
[179] Di Chen,et al. The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression , 2019, Nature Communications.
[180] Zhiguang Zhou,et al. Metformin shows anti‐inflammatory effects in murine macrophages through Dicer/microribonucleic acid‐34a‐5p and microribonucleic acid‐125b‐5p , 2019, Journal of diabetes investigation.
[181] Yi Ding,et al. Effects of TNFR1 gene silencing on early apoptosis of marbofloxacin-treated chondrocytes from juvenile dogs. , 2019, Toxicology.
[182] Fanxin Long. Less Is More: Ditching Mitochondria Saves Hypoxic Cartilage. , 2019, Developmental cell.
[183] A. Giaccia,et al. Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate. , 2019, Developmental cell.
[184] Ranran Li,et al. Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2. , 2019, Biochimica et biophysica acta. Molecular basis of disease.
[185] J. McDougall,et al. Age and frailty as risk factors for the development of osteoarthritis , 2019, Mechanisms of Ageing and Development.
[186] A. Soukas,et al. Metformin: Mechanisms in Human Obesity and Weight Loss , 2019, Current Obesity Reports.
[187] F. Cicuttini,et al. Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study , 2019, Arthritis Research & Therapy.
[188] P. Tak,et al. Therapeutic options for targeting inflammatory osteoarthritis pain , 2019, Nature Reviews Rheumatology.
[189] T. Vasilopoulos,et al. Eccentric and Concentric Resistance Exercise Comparison for Knee Osteoarthritis. , 2019, Medicine and science in sports and exercise.
[190] G. Xiao,et al. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint , 2019, Autophagy.
[191] A. Naraghi,et al. Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation , 2019, Stem cells translational medicine.
[192] N. Ishimaru,et al. Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification. , 2019, Bone.
[193] Di Chen,et al. Activation of β‐catenin in Col2‐expressing chondrocytes leads to osteoarthritis‐like defects in hip joint , 2019, Journal of cellular physiology.
[194] Hongyan Li,et al. MicroRNA-107 regulates autophagy and apoptosis of osteoarthritis chondrocytes by targeting TRAF3. , 2019, International immunopharmacology.
[195] Liu Yang,et al. miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. , 2019, Biomaterials.
[196] Di Chen,et al. Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis , 2019, Annals of the rheumatic diseases.
[197] Xiaoming Yang,et al. Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction , 2019, Bone Research.
[198] R. Papalia,et al. Sport activity as risk factor for early knee osteoarthritis. , 2019, Journal of biological regulators and homeostatic agents.
[199] M. Karsdal,et al. Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients. , 2019, Osteoarthritis and cartilage.
[200] X. Bai,et al. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12 , 2019, Bone Research.
[201] K. Ho,et al. Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade , 2019, Annals of the rheumatic diseases.
[202] R. Guldberg,et al. Regional gene expression analysis of multiple tissues in an experimental animal model of post-traumatic osteoarthritis. , 2019, Osteoarthritis and cartilage.
[203] A. Arsenijević,et al. Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[204] O. Savvidou,et al. Glucocorticoid signaling and osteoarthritis , 2019, Molecular and Cellular Endocrinology.
[205] Yueqi Zhang,et al. Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes. , 2018, Bioscience trends.
[206] M. Reinders,et al. RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage , 2018, Annals of the rheumatic diseases.
[207] R. Kinne,et al. ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment , 2018, Arthritis & rheumatology.
[208] Zheng-Wei Zhu,et al. [Effect of Electroacupuncture on Synovial M 1/M 2 Macrophage Polarization in Rats with Acute Gouty Arthritis]. , 2018, Zhen ci yan jiu = Acupuncture research.
[209] Y. Zhang,et al. The burden for knee osteoarthritis among Chinese elderly: estimates from a nationally representative study. , 2018, Osteoarthritis and cartilage.
[210] Dirk Mossmann,et al. mTOR signalling and cellular metabolism are mutual determinants in cancer , 2018, Nature Reviews Cancer.
[211] Yujie Deng,et al. Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation , 2018, Nature Communications.
[212] H. Xu,et al. Structure and Physiological Regulation of AMPK , 2018, International journal of molecular sciences.
[213] P. Devita,et al. Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better? , 2018, Arthritis care & research.
[214] T. Huizinga,et al. Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial , 2018, Annals of the rheumatic diseases.
[215] V. Rosen,et al. The BMP Pathway and Its Inhibitors in the Skeleton. , 2018, Physiological reviews.
[216] Yin Xiao,et al. Saturated fatty acids promote chondrocyte matrix remodeling through reprogramming of autophagy pathways. , 2018, Nutrition.
[217] Alan J. Grodzinsky,et al. Cartilage diseases. , 2018, Matrix biology : journal of the International Society for Matrix Biology.
[218] R. Lories,et al. A Notch in the joint that exacerbates osteoarthritis , 2018, Nature Reviews Rheumatology.
[219] Feng-Sheng Wang,et al. MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12 , 2018, Cell Death & Disease.
[220] E. Canalis,et al. Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis. , 2018, Bone.
[221] J. Huard,et al. Bone morphogenetic proteins for articular cartilage regeneration. , 2018, Osteoarthritis and cartilage.
[222] D. Neumann. Is TAK1 a Direct Upstream Kinase of AMPK? , 2018, International journal of molecular sciences.
[223] A. Tamm,et al. New insights into the natural course of knee osteoarthritis: early regulation of cytokines and growth factors, with emphasis on sex-dependent angiogenesis and tissue remodeling. A pilot study. , 2018, Osteoarthritis and cartilage.
[224] Peihui Wu,et al. Exosomal miR‐95‐5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8 , 2018, Journal of cellular and molecular medicine.
[225] C. Ding,et al. Systemic and local adipose tissue in knee osteoarthritis. , 2018, Osteoarthritis and cartilage.
[226] Zubin Zhou,et al. Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats , 2018, Pharmacology.
[227] Tang Liu,et al. Treatment of hip osteoarthritis with glucocorticoids , 2018, Annals of the rheumatic diseases.
[228] V. Rosen,et al. The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint , 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[229] C. De Bari,et al. Stem cell‐based therapeutic strategies for cartilage defects and osteoarthritis , 2018, Current opinion in pharmacology.
[230] C. Lohmann,et al. Targeting β-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage. , 2018, Osteoarthritis and cartilage.
[231] G. Superti-Furga,et al. mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation , 2018, Cell reports.
[232] G. Xiao,et al. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ , 2018, The Journal of cell biology.
[233] Mangmang Li,et al. Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway , 2018, Annals of the rheumatic diseases.
[234] N. Chockalingam,et al. A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions , 2018, PloS one.
[235] Ju-Hong Lee,et al. A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients. , 2018, Human gene therapy. Clinical development.
[236] M. Kapoor,et al. Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis. , 2018, JCI insight.
[237] Hao Liu,et al. Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis , 2018, Clinical Rheumatology.
[238] Yi Shen,et al. Comparative effectiveness of glucosamine, chondroitin, acetaminophen or celecoxib for the treatment of knee and/or hip osteoarthritis: a network meta-analysis. , 2018, Clinical and experimental rheumatology.
[239] T. Komori. Runx2, an inducer of osteoblast and chondrocyte differentiation , 2018, Histochemistry and Cell Biology.
[240] Zhaoxun Pan,et al. Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset , 2017, Molecular medicine reports.
[241] A. Kiadaliri,et al. High and rising burden of hip and knee osteoarthritis in the Nordic region, 1990–2015 , 2017, Acta orthopaedica.
[242] M. Delgado-Rodríguez,et al. Systematic review and meta-analysis. , 2017, Medicina intensiva.
[243] N. Bellamy,et al. A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial. , 2017, Osteoarthritis and cartilage.
[244] Masaya Nakamura,et al. Pelvic Tilt Displacement Before and After Artificial Hip Joint Replacement Surgery. , 2018, The Journal of arthroplasty.
[245] J. Hood,et al. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. , 2018, Osteoarthritis and cartilage.
[246] K. Malizos,et al. Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes , 2017, Clinical Epigenetics.
[247] T. Haqqi,et al. A standardized extract of Butea monosperma (Lam.) flowers suppresses the IL-1β-induced expression of IL-6 and matrix-metalloproteases by activating autophagy in human osteoarthritis chondrocytes. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[248] M. Karsdal,et al. Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study. , 2017, Osteoarthritis and cartilage.
[249] Shicheng Yu,et al. The burden and challenges of tuberculosis in China: findings from the Global Burden of Disease Study 2015 , 2017, Scientific Reports.
[250] Yi Dai,et al. Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy , 2017, Diabetes.
[251] Sarah Onuora. Osteoarthritis: Wnt inhibitor shows potential as a DMOAD , 2017, Nature Reviews Rheumatology.
[252] J. Li,et al. Regenerative approaches for cartilage repair in the treatment of osteoarthritis. , 2017, Osteoarthritis and cartilage.
[253] K. Burridge. Focal adhesions: a personal perspective on a half century of progress , 2017, The FEBS journal.
[254] F. Lafeber,et al. Brief Report: Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis , 2017, Arthritis & rheumatology.
[255] W. Reichmann,et al. Healthcare resource utilization and costs by age and joint location among osteoarthritis patients in a privately insured population , 2017, Journal of medical economics.
[256] Di Chen,et al. Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis , 2017, Current Rheumatology Reports.
[257] Heli Maijanen,et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century , 2017, Proceedings of the National Academy of Sciences.
[258] A. Passaniti,et al. Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity , 2017, Oncotarget.
[259] R. Vettor,et al. Systemic and Local Adipose Tissue in Knee Osteoarthritis , 2017, Journal of cellular physiology.
[260] M. G. Krukemeyer,et al. 15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics. , 2017, Pathology, research and practice.
[261] P. Ferreira,et al. Hydrotherapy improves pain and function in older women with knee osteoarthritis: a randomized controlled trial , 2017, Brazilian journal of physical therapy.
[262] L. Troeberg,et al. ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’ , 2017, Osteoarthritis and cartilage.
[263] Yuqing Zhang,et al. Knee Symptomatic Osteoarthritis, Walking Disability, NSAIDs Use and All-cause Mortality: Population-based Wuchuan Osteoarthritis Study , 2017, Scientific Reports.
[264] J. Fernández-Torres,et al. Hypoxia-Inducible Factors (HIFs) in the articular cartilage: a systematic review. , 2017, European review for medical and pharmacological sciences.
[265] T. Aoyama,et al. Physiological exercise loading suppresses post-traumatic osteoarthritis progression via an increase in bone morphogenetic proteins expression in an experimental rat knee model. , 2017, Osteoarthritis and cartilage.
[266] X. Bai,et al. mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. , 2017, Osteoarthritis and cartilage.
[267] R. Nusse,et al. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities , 2017, Cell.
[268] Di Chen,et al. Deletion of Runx2 in Articular Chondrocytes Decelerates the Progression of DMM-Induced Osteoarthritis in Adult Mice , 2017, Scientific Reports.
[269] Jeffrey B. Driban,et al. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial , 2017, JAMA.
[270] L. Tucker-Kellogg,et al. Wnt proteins synergize to activate β-catenin signaling , 2017, Journal of Cell Science.
[271] A. Mobasheri,et al. The role of metabolism in the pathogenesis of osteoarthritis , 2017, Nature Reviews Rheumatology.
[272] Xinqiao Jia,et al. CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus , 2017, Stem Cell Research & Therapy.
[273] H. Bliddal,et al. The effects of intra-articular glucocorticoids and exercise on pain and synovitis assessed on static and dynamic magnetic resonance imaging in knee osteoarthritis: exploratory outcomes from a randomized controlled trial. , 2017, Osteoarthritis and cartilage.
[274] F. Cantatore,et al. Osteoblast role in osteoarthritis pathogenesis , 2017, Journal of cellular physiology.
[275] M. Takigawa,et al. Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis , 2017, Journal of Cell Communication and Signaling.
[276] H. Haisma,et al. Stem cell injections in knee osteoarthritis: a systematic review of the literature , 2017, British Journal of Sports Medicine.
[277] D. Sabatini,et al. mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.
[278] C. Little,et al. Using mouse models to investigate the pathophysiology, treatment, and prevention of post‐traumatic osteoarthritis , 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[279] D. Shi,et al. AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice , 2017, Scientific Reports.
[280] Philip G Conaghan,et al. Synovitis in osteoarthritis: current understanding with therapeutic implications , 2017, Arthritis Research & Therapy.
[281] J. Gu,et al. Crosstalk between Smad2/3 and specific isoforms of ERK in TGF‐β1‐induced TIMP‐3 expression in rat chondrocytes , 2017, Journal of cellular and molecular medicine.
[282] T. Schnitzer,et al. Tanezumab in the treatment of chronic musculoskeletal conditions , 2017, Expert opinion on biological therapy.
[283] X. Bai,et al. Strontium ranelate, a promising disease modifying osteoarthritis drug , 2017, Expert opinion on investigational drugs.
[284] M. Heckman,et al. A Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis , 2017, The American journal of sports medicine.
[285] T. Hügle,et al. What drives osteoarthritis?—synovial versus subchondral bone pathology , 2016, Rheumatology.
[286] Yihe Hu,et al. Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis , 2016, Experimental and therapeutic medicine.
[287] G. Loots,et al. Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis , 2016, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[288] F. Dell’Accio,et al. WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis , 2016, Annals of the rheumatic diseases.
[289] A. de Laat,et al. Network meta-analysis. , 2017, Journal of oral rehabilitation.
[290] M. Xu,et al. Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis. , 2016, Osteoarthritis and cartilage.
[291] M. Poddar,et al. The superior regenerative potential of muscle-derived stem cells for articular cartilage repair is attributed to high cell survival and chondrogenic potential , 2016, Molecular therapy. Methods & clinical development.
[292] Song Ho Chang,et al. Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes , 2016, Nature Communications.
[293] R. Pichyangkura,et al. Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study. , 2016, Pharmacological research.
[294] Di Chen,et al. Runx2 and microRNA regulation in bone and cartilage diseases , 2016, Annals of the New York Academy of Sciences.
[295] Xin Zhang,et al. Inhibition of transforming growth factor β-activated kinase 1 prevents inflammation-related cartilage degradation in osteoarthritis , 2016, Scientific Reports.
[296] J. Schwartz,et al. Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses , 2016, Osteoarthritis and cartilage.
[297] C. Cooper,et al. Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population‐Based Cohort Study , 2016, Arthritis & rheumatology.
[298] C. Zeng,et al. The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity , 2016, BioMed research international.
[299] P. Jepson,et al. Assistive devices, hip precautions, environmental modifications and training to prevent dislocation and improve function after hip arthroplasty. , 2016, The Cochrane database of systematic reviews.
[300] Richard F. Loeser,et al. Ageing and the pathogenesis of osteoarthritis , 2016, Nature Reviews Rheumatology.
[301] Timothy A. Miller,et al. Nanoparticulate Mineralized Collagen Scaffolds and BMP‐9 Induce a Long‐Term Bone Cartilage Construct in Human Mesenchymal Stem Cells , 2016, Advanced healthcare materials.
[302] F. Rannou,et al. Rehabilitation (exercise and strength training) and osteoarthritis: A critical narrative review. , 2016, Annals of physical and rehabilitation medicine.
[303] E. Coudeyre,et al. Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review. , 2016, Annals of physical and rehabilitation medicine.
[304] F. Canovas,et al. Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial , 2016, Stem cells translational medicine.
[305] D. Ummarino. Osteoarthritis: Hypoxia protects against cartilage loss by regulating Wnt signalling , 2016, Nature Reviews Rheumatology.
[306] B. Alman,et al. Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. , 2016, The Journal of clinical investigation.
[307] F. Meng,et al. MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses. , 2016, Osteoarthritis and cartilage.
[308] A. Carr,et al. Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role , 2016, Osteoarthritis and cartilage.
[309] Pascal Richette,et al. Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice , 2016, Proceedings of the National Academy of Sciences.
[310] Aaron T. L. Lun,et al. RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity. , 2016, Cell reports.
[311] Zhenming Hu,et al. BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells , 2016, Cell and Tissue Research.
[312] J. Farr,et al. Bone marrow lesions and subchondral bone pathology of the knee , 2016, Knee Surgery, Sports Traumatology, Arthroscopy.
[313] Vicki Rosen,et al. BMP signalling in skeletal development, disease and repair , 2016, Nature Reviews Endocrinology.
[314] F. Luyten,et al. Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells. , 2016, Tissue engineering. Part C, Methods.
[315] Yuqing Zhang,et al. The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study , 2016, Arthritis & rheumatology.
[316] J. Pelletier,et al. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. , 2016, Seminars in arthritis and rheumatism.
[317] Byung‐Hyun Cha,et al. Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration. , 2016, Osteoarthritis and cartilage.
[318] J. Reginster,et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. , 2016, Seminars in arthritis and rheumatism.
[319] Johanne Martel-Pelletier,et al. Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: Evidence from real-life setting trials and surveys. , 2016, Seminars in arthritis and rheumatism.
[320] Ashutosh Kumar Singh,et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 , 2016, Lancet.
[321] M. Doherty,et al. Paracetamol: not as safe as we thought? A systematic literature review of observational studies , 2015, Annals of the rheumatic diseases.
[322] Xin Xu,et al. Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage , 2014, Annals of the rheumatic diseases.
[323] S. Bonar. Challenging times ahead. , 2016, Midwives.
[324] G. Jay,et al. The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid , 2015, Arthritis Research & Therapy.
[325] P. Emans,et al. BAPX‐1/NKX‐3.2 Acts as a Chondrocyte Hypertrophy Molecular Switch in Osteoarthritis , 2015, Arthritis & rheumatology.
[326] R. Loeser,et al. Aging-related inflammation in osteoarthritis. , 2015, Osteoarthritis and cartilage.
[327] J. Blenis,et al. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. , 2015, Cancer discovery.
[328] H. Hwang,et al. Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis , 2015, International journal of molecular sciences.
[329] Zhe Zhang,et al. The Functions of BMP3 in Rabbit Articular Cartilage Repair , 2015, International journal of molecular sciences.
[330] Xiaoyan Yuan,et al. A pilot study of conically graded chitosan-gelatin hydrogel/PLGA scaffold with dual-delivery of TGF-β1 and BMP-2 for regeneration of cartilage-bone interface. , 2015, Journal of biomedical materials research. Part B, Applied biomaterials.
[331] H. Guo,et al. Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis. , 2015, Genetics and molecular research : GMR.
[332] V. Kraus,et al. Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. , 2015, Osteoarthritis and cartilage.
[333] J. Post,et al. The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes , 2015, International journal of molecular sciences.
[334] K. Jordan,et al. Annual consultation incidence of osteoarthritis estimated from population-based health care data in England , 2015, Rheumatology.
[335] Hongli Jiao,et al. Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis , 2015, Nature Communications.
[336] K. Vuolteenaho,et al. Effects of FGF-2 and FGF receptor antagonists on MMP enzymes, aggrecan, and type II collagen in primary human OA chondrocytes , 2015, Scandinavian journal of rheumatology.
[337] W. B. van den Berg,et al. Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage. , 2015, The American journal of pathology.
[338] Wuyin Li,et al. Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α , 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[339] M. Cohen-Solal,et al. Subchondral bone and osteoarthritis , 2015, Current opinion in rheumatology.
[340] Y. Koh,et al. Mesenchymal Stem Cell Implantation in Knee Osteoarthritis , 2015, The American journal of sports medicine.
[341] T. Yoshii,et al. Repair of osteochondral defects in a rabbit model using a porous hydroxyapatite collagen composite impregnated with bone morphogenetic protein-2. , 2015, Artificial organs.
[342] I. Sekiya,et al. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age , 2015, FEBS letters.
[343] A. Lassar,et al. Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice: FATE-MAPPING OFPrg4-EXPRESSING CHONDROCYTES , 2015 .
[344] R. Terkeltaub,et al. Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator–Activated Receptor γ Coactivator 1α , 2015, Arthritis & rheumatology.
[345] V. Lefebvre,et al. Editorial: Prg4‐Expressing Cells: Articular Stem Cells or Differentiated Progeny in the Articular Chondrocyte Lineage? , 2015, Arthritis & rheumatology.
[346] A. Lassar,et al. Identification of a Prg4‐Expressing Articular Cartilage Progenitor Cell Population in Mice , 2015, Arthritis & rheumatology.
[347] J. Gómez-Reino,et al. Identification of Novel Adipokines in the Joint. Differential Expression in Healthy and Osteoarthritis Tissues , 2015, PloS one.
[348] R. O’Keefe,et al. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis , 2015, Science Signaling.
[349] J. Saklatvala,et al. Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis , 2015, Osteoarthritis and cartilage.
[350] Song Ho Chang,et al. Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 , 2015, Proceedings of the National Academy of Sciences.
[351] B. Pal,et al. mTOR: A Potential Therapeutic Target in Osteoarthritis? , 2015, Drugs in R&D.
[352] Y. Rampersaud,et al. PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage , 2015, Annals of the rheumatic diseases.
[353] J. Pelletier,et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis , 2014, Annals of the rheumatic diseases.
[354] M. Woodward,et al. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens , 2014, Annals of the rheumatic diseases.
[355] Cheng-Li Lin,et al. A population-based cohort study. , 2015 .
[356] T. Schnitzer,et al. A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee. , 2015, Osteoarthritis and cartilage.
[357] V. Geoffroy,et al. Dkk‐1–Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice , 2014, Arthritis & rheumatology.
[358] B. Viollet,et al. Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP‐Activated Protein Kinase , 2014, Arthritis & rheumatology.
[359] G. Hawker,et al. Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. , 2014, Osteoarthritis and cartilage.
[360] T. Diekwisch,et al. Activation of β-catenin signalling leads to temporomandibular joint defects. , 2014, European cells & materials.
[361] Gregory D Jay,et al. The biology of lubricin: near frictionless joint motion. , 2014, Matrix biology : journal of the International Society for Matrix Biology.
[362] D. Saris,et al. Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes , 2014, Arthritis Research & Therapy.
[363] D. Chen,et al. Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis. , 2014, Osteoarthritis and cartilage.
[364] R. Haydon,et al. Bone Morphogenetic Protein (BMP) signaling in development and human diseases , 2014, Genes & diseases.
[365] M. Kloppenburg. Hand osteoarthritis—nonpharmacological and pharmacological treatments , 2014, Nature Reviews Rheumatology.
[366] A. Masuda,et al. Verapamil Protects against Cartilage Degradation in Osteoarthritis by Inhibiting Wnt/β-Catenin Signaling , 2014, PloS one.
[367] F. Beier,et al. Chondrocyte hypertrophy in skeletal development, growth, and disease. , 2014, Birth defects research. Part C, Embryo today : reviews.
[368] Song Ho Chang,et al. Identification of Fibroblast Growth Factor-18 as a Molecule to Protect Adult Articular Cartilage by Gene Expression Profiling* , 2014, The Journal of Biological Chemistry.
[369] T. Vos,et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study , 2014, Annals of the rheumatic diseases.
[370] T. Vos,et al. The global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 study , 2014, Annals of the rheumatic diseases.
[371] D. Hunter,et al. The epidemiology of osteoarthritis. , 2014, Best practice & research. Clinical rheumatology.
[372] J. Katz,et al. The role of arthroscopy in the management of knee osteoarthritis. , 2014, Best practice & research. Clinical rheumatology.
[373] A. Grodzinsky,et al. Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways , 2014, Genes & development.
[374] Thomas M. Schmitt,et al. Re‐adapting T cells for cancer therapy: from mouse models to clinical trials , 2014, Immunological reviews.
[375] Bin Huang,et al. Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice , 2013, Annals of the rheumatic diseases.
[376] R. Cate,et al. CACP syndrome: identification of five novel mutations and of the first case of UPD in the largest European cohort , 2013, European Journal of Human Genetics.
[377] Daniel Prieto-Alhambra,et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints , 2013, Annals of the rheumatic diseases.
[378] R. Terkeltaub,et al. C/EBP homologous protein drives pro-catabolic responses in chondrocytes , 2013, Arthritis Research & Therapy.
[379] Andy H. Choi,et al. Current Perspectives , 2013, Journal of dental research.
[380] O. Uthman,et al. Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis , 2013, BMJ : British Medical Journal.
[381] A. Sutton,et al. Acupuncture and other physical treatments for the relief of pain due to osteoarthritis of the knee: network meta-analysis☆ , 2013, Osteoarthritis and cartilage.
[382] Helen H. W. Chen,et al. Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway. , 2013, American journal of respiratory cell and molecular biology.
[383] D. Hunter,et al. Post-traumatic osteoarthritis: from mouse models to clinical trials , 2013, Nature Reviews Rheumatology.
[384] R. Terkeltaub,et al. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes , 2013, Arthritis Research & Therapy.
[385] A. Liddle,et al. Knee replacement for osteoarthritis. , 2013, Maturitas.
[386] Michael Katanka,et al. Promise and Practice , 2013 .
[387] R. Geenen,et al. EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis , 2013, Annals of the rheumatic diseases.
[388] P. Emans,et al. Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7. , 2013, Osteoarthritis and cartilage.
[389] L. Riley,et al. Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis , 2013, Nature Medicine.
[390] Gene Lee,et al. Chondrogenesis of periodontal ligament stem cells by transforming growth factor-β3 and bone morphogenetic protein-6 in a normal healthy impacted third molar , 2013, International Journal of Oral Science.
[391] Jiyeon Han,et al. MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity. , 2013, Biochemical and biophysical research communications.
[392] Yin Xiao,et al. Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis , 2013, Journal of cellular biochemistry.
[393] H. Im,et al. MMP13 is a critical target gene during the progression of osteoarthritis , 2013, Arthritis Research & Therapy.
[394] 温春毅,et al. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis , 2013 .
[395] Di Chen,et al. Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. , 2012, Arthritis and rheumatism.
[396] M. Hochberg,et al. Osteoarthritis year 2012 in review: clinical. , 2012, Osteoarthritis and cartilage.
[397] David B. Burr,et al. Bone remodelling in osteoarthritis , 2012, Nature Reviews Rheumatology.
[398] J. Chun,et al. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. , 2012, Arthritis and rheumatism.
[399] Scott J Hollister,et al. Three-dimensional polycaprolactone scaffold-conjugated bone morphogenetic protein-2 promotes cartilage regeneration from primary chondrocytes in vitro and in vivo without accelerated endochondral ossification. , 2012, Journal of biomedical materials research. Part A.
[400] Konrad Basler,et al. The many faces and functions of β‐catenin , 2012, The EMBO journal.
[401] Hans Clevers,et al. Wnt/β-Catenin Signaling and Disease , 2012, Cell.
[402] Konstantinos N Malizos,et al. Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes , 2012, Arthritis Research & Therapy.
[403] Gordon Guyatt,et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee , 2012, Arthritis care & research.
[404] J. Voncken,et al. Activation of NF-κB/p65 Facilitates Early Chondrogenic Differentiation during Endochondral Ossification , 2012, PloS one.
[405] Kyeong Lee,et al. Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. , 2012, European journal of medicinal chemistry.
[406] G. Semenza,et al. Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.
[407] E. Mohammadi,et al. Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.
[408] B. Gallagher,et al. Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis. , 2012, Journal of medicinal chemistry.
[409] M. Lotz,et al. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis , 2011, Annals of the rheumatic diseases.
[410] C. Malemud. Cytokines as Therapeutic Targets for Osteoarthritis , 2012, BioDrugs.
[411] P. Fortina,et al. Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells , 2011, Laboratory Investigation.
[412] D. Pereira,et al. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. , 2011, Osteoarthritis and cartilage.
[413] Brendan H. Lee,et al. Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[414] J. Campisi,et al. Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype* , 2011, The Journal of Biological Chemistry.
[415] L. Shang,et al. AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation , 2011, Autophagy.
[416] D. Hargreaves,et al. Selective non zinc binding inhibitors of MMP13. , 2011, Bioorganic & medicinal chemistry letters.
[417] R. Terkeltaub,et al. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. , 2011, Arthritis and rheumatism.
[418] F. Berenbaum,et al. Osteoarthritis: an update with relevance for clinical practice , 2011, The Lancet.
[419] T. Yasuda. Activation of Akt leading to NF-κB up-regulation in chondrocytes stimulated with fibronectin fragment. , 2011, Biomedical research.
[420] A. Javed,et al. Runx2 Regulates the Gene Network Associated with Insulin Signaling and Energy Homeostasis , 2011, Cells Tissues Organs.
[421] Fumiaki Sato,et al. MicroRNAs and epigenetics , 2011, The FEBS journal.
[422] J. Thumboo,et al. An overview of OA research in two urban APLAR populations , 2011, International journal of rheumatic diseases.
[423] J. Campisi,et al. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype , 2011, The EMBO journal.
[424] F. Blanco,et al. The role of mitochondria in osteoarthritis , 2011, Nature Reviews Rheumatology.
[425] H. Roach,et al. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. , 2011, European cells & materials.
[426] J. Kim,et al. Enhanced proliferation and chondrogenic differentiation of human synovium-derived stem cells expanded with basic fibroblast growth factor. , 2011, Tissue engineering. Part A.
[427] B. Viollet,et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.
[428] A. Giaccia,et al. Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development , 2011, Nature Medicine.
[429] Johanne Martel-Pelletier,et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis , 2011, Nature Reviews Rheumatology.
[430] S. Honsawek,et al. Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients , 2010, BMC musculoskeletal disorders.
[431] Dean M. Messing,et al. Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes. , 2010, Arthritis and rheumatism.
[432] Lin-Feng Chen,et al. Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. , 2010, Cellular signalling.
[433] D. Klionsky. The autophagy connection. , 2010, Developmental cell.
[434] Jonghwan Kim,et al. Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction , 2010, Nature Medicine.
[435] Kozo Nakamura,et al. Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development , 2010, Nature Medicine.
[436] T. Kirkwood,et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease , 2010, Annals of the rheumatic diseases.
[437] M. Goldring,et al. NF-kappaB signaling: multiple angles to target OA. , 2010, Current drug targets.
[438] R. O’Keefe,et al. β‐catenin, cartilage, and osteoarthritis , 2010, Annals of the New York Academy of Sciences.
[439] G. Schett,et al. Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNFα single-chain Fv antibody (ESBA105) designed for local therapeutic use , 2009, Annals of the rheumatic diseases.
[440] I. Harris,et al. A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2010 .
[441] M. Goldring,et al. NF-kappaB signaling: multiple angles to target OA. , 2010, Current drug targets.
[442] S. Dunwoodie. The role of hypoxia in development of the Mammalian embryo. , 2009, Developmental cell.
[443] Z. Werb,et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. , 2009, Arthritis and rheumatism.
[444] S. Mackem,et al. Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. , 2009, The American journal of pathology.
[445] S. Ghosh,et al. The NF-kappaB family of transcription factors and its regulation. , 2009, Cold Spring Harbor perspectives in biology.
[446] R. B. Kelly. Acupuncture for pain. , 2009, American family physician.
[447] E. Novellino,et al. N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. , 2009, Journal of medicinal chemistry.
[448] I. Sekiya,et al. Periodic knee injections of BMP‐7 delay cartilage degeneration induced by excessive running in rats , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[449] M. Schweitzer,et al. Pre- and postoperative assessment in joint preserving and replacing surgery. , 2009, Rheumatic diseases clinics of North America.
[450] Xi He,et al. Wnt/beta-catenin signaling: components, mechanisms, and diseases. , 2009, Developmental cell.
[451] A. Aszódi,et al. β1 Integrin Deficiency Results in Multiple Abnormalities of the Knee Joint* , 2009, The Journal of Biological Chemistry.
[452] J. Herndon,et al. Gender differences in osteoarthritis. , 2009, Menopause.
[453] M. Goldring,et al. Cartilage homeostasis in health and rheumatic diseases , 2009, Arthritis research & therapy.
[454] D. Felson,et al. The high prevalence of knee osteoarthritis in a rural Chinese population: the Wuchuan osteoarthritis study. , 2009, Arthritis and rheumatism.
[455] M. Mohammadi,et al. The FGF family: biology, pathophysiology and therapy , 2009, Nature Reviews Drug Discovery.
[456] W. B. van den Berg,et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. , 2009, Arthritis and rheumatism.
[457] R. O’Keefe,et al. Activation of β‐Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis‐Like Phenotype in Adult β‐Catenin Conditional Activation Mice , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[458] F. De Luca,et al. Stimulatory Effects of Insulin-like Growth Factor-I on Growth Plate Chondrogenesis Are Mediated by Nuclear Factor-κB p65* , 2008, Journal of Biological Chemistry.
[459] Xiaojuan Li,et al. Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T. , 2008, Osteoarthritis and cartilage.
[460] T. Suda,et al. Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis , 2008, Arthritis research & therapy.
[461] R. Cancedda,et al. p38/NF‐kB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes , 2008, Journal of cellular biochemistry.
[462] R. O’Keefe,et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. , 2008, Arthritis and rheumatism.
[463] Katerina Akassoglou,et al. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α , 2008, Nature.
[464] C. Scanzello,et al. The Post-NSAID Era: What to use now for the pharmacologic treatment of pain and inflammation in osteoarthritis , 2008, Current rheumatology reports.
[465] Gun-Hee Kim,et al. Basic fibroblast growth factor accelerates matrix degradation via a neuro‐endocrine pathway in human adult articular chondrocytes , 2008, Journal of cellular physiology.
[466] R. O’Keefe,et al. Inhibition of β-catenin signaling causes defects in postnatal cartilage development , 2008, Journal of Cell Science.
[467] D. Galson,et al. General Transcription Factor IIA-γ Increases Osteoblast-specific Osteocalcin Gene Expression via Activating Transcription Factor 4 and Runt-related Transcription Factor 2* , 2008, Journal of Biological Chemistry.
[468] P Tugwell,et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. , 2008, Osteoarthritis and cartilage.
[469] F. Schmidt. Meta-Analysis , 2008 .
[470] J. Schrooten,et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. , 2007, Arthritis and rheumatism.
[471] T. Spector,et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study , 2007, Arthritis research & therapy.
[472] W. B. van den Berg,et al. Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling , 2007, Arthritis research & therapy.
[473] K. Gelse,et al. Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments , 2007, Current opinion in rheumatology.
[474] J. Saklatvala,et al. FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. , 2007, Osteoarthritis and cartilage.
[475] J. Block,et al. Basic Fibroblast Growth Factor Stimulates Matrix Metalloproteinase-13 via the Molecular Cross-talk between the Mitogen-activated Protein Kinases and Protein Kinase Cδ Pathways in Human Adult Articular Chondrocytes* , 2007, Journal of Biological Chemistry.
[476] F. Canovas,et al. Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes , 2007, Arthritis research & therapy.
[477] R. Christensen,et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. , 2007, The Cochrane database of systematic reviews.
[478] M. Carlson,et al. Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro* , 2006, Journal of Biological Chemistry.
[479] M. Dougados. Why and How to Use NSAIDs in Osteoarthritis , 2006, Journal of cardiovascular pharmacology.
[480] A. Hoffmann,et al. Circuitry of nuclear factor κB signaling , 2006 .
[481] B. Bannwarth. Acetaminophen or NSAIDs for the treatment of osteoarthritis. , 2006, Best practice & research. Clinical rheumatology.
[482] Michael H Weisman,et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. , 2006, The New England journal of medicine.
[483] S. Ghosh,et al. Role of nuclear factor‐κB in the immune system and bone , 2005 .
[484] Steven P. Gygi,et al. mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events , 2005, Cell.
[485] B. Thisse,et al. Functions and regulations of fibroblast growth factor signaling during embryonic development. , 2005, Developmental biology.
[486] G. Karsenty,et al. Cooperative Interactions between Activating Transcription Factor 4 and Runx2/Cbfa1 Stimulate Osteoblast-specific Osteocalcin Gene Expression* , 2005, Journal of Biological Chemistry.
[487] G. Xiao,et al. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[488] A. Sanabria,et al. Randomized controlled trial. , 2005, World journal of surgery.
[489] G. Fantuzzi. Adipose tissue, adipokines, and inflammation. , 2005, The Journal of allergy and clinical immunology.
[490] H. Clevers,et al. Wnt signalling in stem cells and cancer , 2005, Nature.
[491] Shaun K Olsen,et al. Structural basis for fibroblast growth factor receptor activation. , 2005, Cytokine & growth factor reviews.
[492] A. Fourie,et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro , 2005, Nature.
[493] H. Ma,et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis , 2005, Nature.
[494] Véronique Lefebvre,et al. The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. , 2005, The Journal of clinical investigation.
[495] B. Bresnihan,et al. Synovial tissue inflammation in early and late osteoarthritis , 2005, Annals of the rheumatic diseases.
[496] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[497] V. Vad,et al. Osteoarthritis case study. , 2005, Orthopedics.
[498] D. Walsh,et al. Osteoarthritis, angiogenesis and inflammation. , 2005, Rheumatology.
[499] B. Swoboda,et al. Hypoxia and HIF-1alpha in osteoarthritis. , 2005, International orthopaedics.
[500] B. Swoboda,et al. Hypoxia and HIF-1α in osteoarthritis , 2005, International Orthopaedics.
[501] G. Thomas,et al. Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development , 2004, Molecular and Cellular Biology.
[502] L. Topol,et al. Wnt/β-catenin signaling is sufficient and necessary for synovial joint formation , 2004 .
[503] M. Noda,et al. Aged Mice Require Full Transcription Factor, Runx2/Cbfa1, Gene Dosage for Cancellous Bone Regeneration After Bone Marrow Ablation , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[504] L. Southam,et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[505] P. McCrea,et al. Interactions between Sox9 and β-catenin control chondrocyte differentiation , 2004 .
[506] S. Abramson,et al. Inflammation in osteoarthritis. , 2004, The Journal of rheumatology. Supplement.
[507] P. McCrea,et al. Interactions between Sox9 and beta-catenin control chondrocyte differentiation. , 2004, Genes & development.
[508] Xizhi Guo,et al. Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. , 2004, Genes & development.
[509] Michael D Maloney,et al. Articular Cartilage Biology , 2003, The Journal of the American Academy of Orthopaedic Surgeons.
[510] P Tugwell,et al. Thermotherapy for treatment of osteoarthritis. , 2003, The Cochrane database of systematic reviews.
[511] J. Smolen,et al. Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. , 2003, Arthritis and rheumatism.
[512] Brendan H. Lee,et al. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte–specific expression in vivo , 2003, The Journal of cell biology.
[513] M. Nevitt,et al. Lower prevalence of hand osteoarthritis among Chinese subjects in Beijing compared with white subjects in the United States: the Beijing Osteoarthritis Study. , 2003, Arthritis and rheumatism.
[514] Peter McIntyre,et al. ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures , 2003, Cell.
[515] G. Xiao,et al. Multiple Signaling Pathways Converge on the Cbfa1/Runx2 Transcription Factor to Regulate Osteoblast Differentiation , 2003 .
[516] G. Xiao,et al. Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation. , 2003, Connective tissue research.
[517] G. Xiao,et al. Fibroblast Growth Factor 2 Induction of the Osteocalcin Gene Requires MAPK Activity and Phosphorylation of the Osteoblast Transcription Factor, Cbfa1/Runx2* , 2002, The Journal of Biological Chemistry.
[518] S. Cummings,et al. Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. , 2002, Arthritis and rheumatism.
[519] R. Loeser,et al. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. , 2002, Arthritis and rheumatism.
[520] I Petersen,et al. Grading of chronic synovitis--a histopathological grading system for molecular and diagnostic pathology. , 2002, Pathology, research and practice.
[521] S. Gabriel,et al. Systematic Review of the Literature , 2021, Adherence to Antiretroviral Therapy among Perinatal Women in Guyana.
[522] T Kobayashi,et al. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. , 2001, Genes & development.
[523] M. Nevitt,et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. , 2001, Arthritis and rheumatism.
[524] S. Abramson,et al. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. , 2001, Arthritis and rheumatism.
[525] Thomas Aigner,et al. Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis , 2001, Arthritis Research & Therapy.
[526] Y. Kitamura,et al. Cbfa1 Is a Positive Regulatory Factor in Chondrocyte Maturation* , 2000, The Journal of Biological Chemistry.
[527] S. Schwartz,et al. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome , 1999, Nature Genetics.
[528] M. Taketo,et al. Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene , 1999, The EMBO journal.
[529] D. Salter,et al. Integrin-regulated Secretion of Interleukin 4: A Novel Pathway of Mechanotransduction in Human Articular Chondrocytes , 1999, The Journal of cell biology.
[530] R. Gaynor,et al. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β , 1998, Nature.
[531] W. B. van den Berg,et al. Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. , 1998, Osteoarthritis and cartilage.
[532] I. Verma,et al. Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb , 1998, Nature.
[533] M. Warman,et al. The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. , 1998, Arthritis and rheumatism.
[534] R. Gaynor,et al. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. , 1998, Nature.
[535] Kohei Miyazono,et al. TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.
[536] R. Vakkalanka,et al. Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand. , 1997, The Journal of clinical investigation.
[537] J. Caamaño,et al. Osteopetrosis in mice lacking NF-κB1 and NF-κB2 , 1997, Nature Medicine.
[538] S. Mundlos,et al. Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development , 1997, Cell.
[539] A. Gatherer,et al. Sarcoma of the Larynx , 1958, The Journal of Laryngology & Otology.
[540] N L Fazzalari,et al. Fractal Properties of Subchondral Cancellous Bone in Severe Osteoarthritis of the Hip , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[541] M. Smith,et al. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. , 1997, The Journal of rheumatology.
[542] K. Miyazono,et al. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. , 1997, Nature.
[543] J. Caamaño,et al. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. , 1997, Nature medicine.
[544] A J Bailey,et al. Biochemical evidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip. , 1997, British journal of rheumatology.
[545] N. Perrimon,et al. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. , 1996, Genes & development.
[546] T. Spector,et al. The association between osteoarthritis and osteoporotic fracture: the Chingford Study. , 1996, British journal of rheumatology.
[547] E. Thonar,et al. Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. , 1996, Arthritis and rheumatism.
[548] P. Leder,et al. Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth , 1996, Cell.
[549] A M Walker,et al. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. , 1995, Arthritis and rheumatism.
[550] T. Hardingham,et al. Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype. , 1995, Arthritis and rheumatism.
[551] J. Cidlowski,et al. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors , 1995, Molecular and cellular biology.
[552] F. Luyten,et al. Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. , 1994, Experimental cell research.
[553] Daniel Levy,et al. Bone mineral density and knee osteoarthritis in elderly men and women. The Framingham Study. , 1993, Arthritis and rheumatism.
[554] P Young,et al. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. , 1993, Annals of the rheumatic diseases.
[555] P. Dieppe,et al. Management of osteoarthritis of the hip and knee joints. , 1993, Current opinion in rheumatology.
[556] P. Revell,et al. Remodelling of subchondral bone in osteoarthritis: a histomorphometric study. , 1992, Journal of clinical pathology.
[557] Y. Yarden,et al. Developmental expression of two murine fibroblast growth factor receptors, flg and bek. , 1991, Development.
[558] M. Schünke,et al. Subchondral bone formation in arthrosis. Polychrome labeling studies in mice. , 1988, Acta orthopaedica Scandinavica.
[559] Robert C. Wolpert,et al. A Review of the , 1985 .
[560] K. Schwarz. The Chingford Study. , 1981, Public health.
[561] E. Glaser. The randomized clinical trial. , 1972, The New England journal of medicine.
[562] J. Trueta,et al. Ageing and Osteoarthritis , 1959 .