Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity

[1]  Christos G Mihos,et al.  The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in renal disease , 2014, International journal of nephrology and renovascular disease.

[2]  Jin-jin Fan,et al.  Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA , 2013, Rheumatology International.

[3]  Yuejin Yang,et al.  Phosphorylation of endothelial NOS contributes to simvastatin protection against myocardial no-reflow and infarction in reperfused swine hearts: partially via the PKA signaling pathway , 2012, Acta Pharmacologica Sinica.

[4]  Oliver Soehnlein,et al.  Multiple roles for neutrophils in atherosclerosis. , 2012, Circulation research.

[5]  J. Yang,et al.  Simvastatin reduces VCAM-1 expression in human umbilical vein endothelial cells exposed to lipopolysaccharide , 2012, Inflammation Research.

[6]  S. Saad,et al.  Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin , 2011, Haematologica.

[7]  Christos G Mihos,et al.  The Pleiotropic Effects of the Hydroxy-Methyl-Glutaryl-CoA Reductase Inhibitors in Cardiovascular Disease: A Comprehensive Review , 2010, Cardiology in review.

[8]  M. Borggrefe,et al.  Effect of atorvastatin on cellular adhesion molecules on leukocytes in patients with normocholesterolemic coronary artery disease. , 2010, In vivo.

[9]  Stephan Huveneers,et al.  Adhesion signaling – crosstalk between integrins, Src and Rho , 2009, Journal of Cell Science.

[10]  F. Costa,et al.  Newer Aspects of the Pathophysiology of Sickle Cell Disease Vaso-Occlusion , 2009, Hemoglobin.

[11]  J. Burke,et al.  Statins alter neutrophil migration by modulating cellular Rho activity—a potential mechanism for statins‐mediated pleotropic effects? , 2008, Journal of leukocyte biology.

[12]  S. Homer-Vanniasinkam,et al.  Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leukocyte adhesion under flow. , 2008, Atherosclerosis.

[13]  K. Ley,et al.  Induction of LFA‐1‐Dependent Neutrophil Rolling on ICAM‐1 by Engagement of E‐Selectin , 2006, Microcirculation.

[14]  S. Stevens,et al.  Nitric Oxide Mediates the Effect of Fluvastatin on Intercellular Adhesion Molecule-1 and Platelet EndothelialCell Adhesion Molecule-1 Expressionon Human Endothelial cells , 2005, Annals of vascular surgery.

[15]  K. Ley,et al.  L‐selectin: mechanisms and physiological significance of ectodomain cleavage , 2005, Journal of cellular and molecular medicine.

[16]  F. Costa,et al.  Effect of Cytokines and Chemokines on Sickle Neutrophil Adhesion to Fibronectin , 2005, Acta Haematologica.

[17]  J. Kallen,et al.  Improved Lymphocyte Function-associated Antigen-1 (LFA-1) Inhibition by Statin Derivatives , 2004, Journal of Biological Chemistry.

[18]  N. Idkaidek,et al.  Pharmacokinetics and bioequivalence evaluation of two simvastatin 40 mg tablets (Simvast & Zocor) in healthy human volunteers , 2003, Biopharmaceutics & drug disposition.

[19]  C. Wiedermann,et al.  Rho-GTPase–Dependent Platelet-Neutrophil Interaction Affected by HMG-CoA Reductase Inhibition With Altered Adenosine Nucleotide Release and Function , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[20]  C. Stancu,et al.  Statins: mechanism of action and effects , 2001, Journal of cellular and molecular medicine.

[21]  Joerg Kallen,et al.  Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site , 2001, Nature Medicine.

[22]  U. Laufs,et al.  Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. , 1998, Circulation.

[23]  D. Priebat,et al.  Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. , 1982, The Journal of investigative dermatology.

[24]  Springer Basel Ag.  Simvastatin reduces VCAM-1 expression in human umbilical vein endothelial cells exposed to lipopolysaccharide , 2012 .

[25]  N. Idkaidek,et al.  Pharmacokinetics and bioequivalence evaluation of two simvastatin 40 mg tablets (Simvast and Zocor) in healthy human volunteers. , 2003, Biopharmaceutics & drug disposition.

[26]  F. Luft,et al.  Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by ANCA. , 2003, Kidney international.