Trio Haploinsufficiency Causes Neurodevelopmental Disease–Associated Deficits

[1]  Karolinska Schizophrenia Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium , 2018 .

[2]  Adrian Preda,et al.  Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium , 2018, Biological Psychiatry.

[3]  Ronald J. Moore,et al.  Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography–mass spectrometry , 2018, Nature Protocols.

[4]  R. Mains,et al.  Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity , 2017, Human molecular genetics.

[5]  C. Greer,et al.  CNS Neurons Deposit Laminin α5 to Stabilize Synapses , 2017, Cell reports.

[6]  Vsevolod Katritch,et al.  An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio , 2017, Nature Communications.

[7]  Qian Li,et al.  Refinement of learned skilled movement representation in motor cortex deep output layer , 2017, Nature Communications.

[8]  V. Martínez‐Cerdeño,et al.  Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models , 2017, Developmental neurobiology.

[9]  N. Tamamaki,et al.  Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice , 2017, Biological Psychiatry.

[10]  Giulio Genovese,et al.  Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia , 2016, Nature Neuroscience.

[11]  M. Higley,et al.  Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice , 2016, The Journal of Neuroscience.

[12]  L. Vissers,et al.  TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function. , 2016, Human molecular genetics.

[13]  R. Nicoll,et al.  Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP , 2016, Proceedings of the National Academy of Sciences.

[14]  Neville E. Sanjana,et al.  Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects , 2016, Neuron.

[15]  James Y. Zou Analysis of protein-coding genetic variation in 60,706 humans , 2015, Nature.

[16]  V. Luine,et al.  The evolving role of dendritic spines and memory: Interaction(s) with estradiol , 2015, Hormones and Behavior.

[17]  Tingting Zhang,et al.  Trio gene is required for mouse learning ability , 2015, Brain Research.

[18]  J. Coyle,et al.  Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. , 2014, JAMA psychiatry.

[19]  Sascha Sauer,et al.  PHOXTRACK-a tool for interpreting comprehensive datasets of post-translational modifications of proteins , 2014, Bioinform..

[20]  Christopher S. Poultney,et al.  Synaptic, transcriptional, and chromatin genes disrupted in autism , 2014, Nature.

[21]  N. Galjart,et al.  Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension , 2014, Current Biology.

[22]  Stephan J Sanders,et al.  A framework for the interpretation of de novo mutation in human disease , 2014, Nature Genetics.

[23]  M. Kane,et al.  Marble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice. , 2013, Journal of visualized experiments : JoVE.

[24]  Tyrone D. Cannon,et al.  Premorbid functional development and conversion to psychosis in clinical high-risk youths , 2013, Development and Psychopathology.

[25]  Sarah J. Cohen,et al.  The Rodent Hippocampus Is Essential for Nonspatial Object Memory , 2013, Current Biology.

[26]  R. Deacon Measuring the Strength of Mice , 2013, Journal of visualized experiments : JoVE.

[27]  R. Mains,et al.  Neuronal Rho GEFs in Synaptic Physiology and Behavior , 2013, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[28]  M. Yeckel,et al.  Abl2/Arg Controls Dendritic Spine and Dendrite Arbor Stability via Distinct Cytoskeletal Control Pathways , 2013, The Journal of Neuroscience.

[29]  B. Firestein,et al.  The dendritic tree and brain disorders , 2012, Molecular and Cellular Neuroscience.

[30]  D. N. Cox,et al.  The RhoGEF Trio Functions in Sculpting Class Specific Dendrite Morphogenesis in Drosophila Sensory Neurons , 2012, PloS one.

[31]  E. Giniger,et al.  Control of Dendritic Morphogenesis by Trio in Drosophila melanogaster , 2012, PloS one.

[32]  C. Pittenger,et al.  Lesions of the dorsomedial striatum disrupt prepulse inhibition , 2011, Neuroscience.

[33]  Pei-Hsin Huang,et al.  Disrupted-in-Schizophrenia 1–mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling , 2011, Proceedings of the National Academy of Sciences.

[34]  Yi Zuo,et al.  Spine plasticity in the motor cortex , 2011, Current Opinion in Neurobiology.

[35]  Cheng-Hai Zhang,et al.  Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum* , 2010, The Journal of Biological Chemistry.

[36]  John H. White,et al.  Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons , 2010, Neuron.

[37]  J. Hutsler,et al.  Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders , 2010, Brain Research.

[38]  G. Davis,et al.  Formin-Dependent Synaptic Growth: Evidence That Dlar Signals via Diaphanous to Modulate Synaptic Actin and Dynamic Pioneer Microtubules , 2008, The Journal of Neuroscience.

[39]  JaneR . Taylor,et al.  Inhibition of Rho via Arg and p190RhoGAP in the Postnatal Mouse Hippocampus Regulates Dendritic Spine Maturation, Synapse and Dendrite Stability, and Behavior , 2007, The Journal of Neuroscience.

[40]  M. Casanova,et al.  The Neuropathology of Autism , 2007, Brain pathology.

[41]  D. Porteous,et al.  Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels , 2007, The Journal of Neuroscience.

[42]  O. Hermanson,et al.  Genetic targeting of principal neurons in neocortex and hippocampus of NEX‐Cre mice , 2006, Genesis.

[43]  A. Williamson,et al.  Integrin-Mediated Dendrite Branch Maintenance Requires Abelson (Abl) Family Kinases , 2005, The Journal of Neuroscience.

[44]  R. Mains,et al.  Multiple novel isoforms of Trio are expressed in the developing rat brain. , 2005, Gene.

[45]  M. Nicolelis,et al.  Differential Corticostriatal Plasticity during Fast and Slow Motor Skill Learning in Mice , 2004, Current Biology.

[46]  Gordon K Smyth,et al.  Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2004, Statistical applications in genetics and molecular biology.

[47]  M. Geyer,et al.  Assessment of Murine Startle Reactivity, Prepulse Inhibition, and Habituation , 2003, Current protocols in neuroscience.

[48]  L. Luo,et al.  Rac function and regulation during Drosophila development , 2002, Nature.

[49]  T. Stossel,et al.  The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin , 2000, Nature Cell Biology.

[50]  S. O’Brien,et al.  Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Donoghue,et al.  Learning-induced LTP in neocortex. , 2000, Science.

[52]  G. Feng,et al.  Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP , 2000, Neuron.

[53]  B. Dickson,et al.  Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila , 2000, Cell.

[54]  Kei Ito,et al.  The Drosophila Trio Plays an Essential Role in Patterning of Axons by Regulating Their Directional Extension , 2000, Neuron.

[55]  Huidy Shu,et al.  The Guanine Nucleotide Exchange Factor Trio Mediates Axonal Development in the Drosophila Embryo , 2000, Neuron.

[56]  J. Rotrosen,et al.  Impaired prepulse inhibition of acoustic startle in schizophrenia , 2000, Biological Psychiatry.

[57]  A. Debant,et al.  TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG. , 2000, Journal of cell science.

[58]  JaneR . Taylor,et al.  Activation of cAMP-Dependent Protein Kinase A in Prefrontal Cortex Impairs Working Memory Performance , 1999, The Journal of Neuroscience.

[59]  T. Pawson,et al.  UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans , 1998, Cell.

[60]  S. Diriong,et al.  The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo , 1998, Oncogene.

[61]  A. Debant,et al.  The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[62]  R. Clark,et al.  Object recognition memory and the rodent hippocampus. , 2010, Learning & memory.

[63]  D. Lewis,et al.  Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. , 2000, Archives of general psychiatry.

[64]  E. Walker,et al.  Neuromotor precursors of schizophrenia. , 1994, Schizophrenia bulletin.