A Cdc42 Activation Cycle Coordinated by PI 3-Kinase during Fc Receptor-mediated Phagocytosis

During Fc receptor-mediated phagocytosis in macrophages, PI 3-kinase mediates transitions in the signaling by Rho-family GTPases. Receptor-activated Cdc42 increases PI 3-kinase activity. Increased 3′ phosphoinositide concentrations in phagocytic cups then deactivate Cdc42.

[1]  J. Swanson,et al.  Fluorescence resonance energy transfer-based stoichiometry in living cells. , 2002, Biophysical journal.

[2]  Joel A. Swanson,et al.  Shaping cups into phagosomes and macropinosomes , 2008, Nature Reviews Molecular Cell Biology.

[3]  S. Grinstein,et al.  Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis , 2005, The Journal of cell biology.

[4]  A. Hall,et al.  Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. , 1998, Science.

[5]  E. Särndahl,et al.  Inactivation of Cdc42 Is Necessary for Depolymerization of Phagosomal F-Actin and Subsequent Phagosomal Maturation1 , 2007, The Journal of Immunology.

[6]  G. Bokoch,et al.  Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes , 1997, The Journal of experimental medicine.

[7]  C. Tseng,et al.  A Requirement for ARF6 in Fcγ Receptor-mediated Phagocytosis in Macrophages* , 1998, The Journal of Biological Chemistry.

[8]  S. Grinstein,et al.  Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation , 2001, The Journal of cell biology.

[9]  S. Grinstein,et al.  Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis , 2001, The Journal of cell biology.

[10]  P. Caroni,et al.  A role for cofilin and LIM kinase in Listeria-induced phagocytosis , 2001, The Journal of cell biology.

[11]  M. Frohman,et al.  Phosphatidylinositol 4-Phosphate 5-Kinase a Is a Downstream Effector of the Small G Protein ARF 6 in Membrane Ruffle Formation 1984 , 1999 .

[12]  M. Falasca,et al.  Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains* , 1998, The Journal of Biological Chemistry.

[13]  J. Davies,et al.  Molecular Biology of the Cell , 1983, Bristol Medico-Chirurgical Journal.

[14]  S. Grinstein,et al.  Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis , 2000, The Journal of cell biology.

[15]  C Kinnon,et al.  Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis. , 2000, Blood.

[16]  M. Rosen,et al.  Specific Patterns of Cdc42 Activity Are Related to Distinct Elements of T Cell Polarization1 , 2006, The Journal of Immunology.

[17]  C. Tseng,et al.  A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension* , 1999, The Journal of Biological Chemistry.

[18]  J. Swanson,et al.  A Phosphatidylinositol-3-Kinase-Dependent Signal Transition Regulates ARF1 and ARF6 during Fcγ Receptor-Mediated Phagocytosis , 2006, PLoS biology.

[19]  J. Swanson,et al.  A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages , 1996, The Journal of cell biology.

[20]  J. Olefsky,et al.  Cdc42 Is a Rho GTPase Family Member That Can Mediate Insulin Signaling to Glucose Transport in 3T3-L1 Adipocytes* , 2003, The Journal of Biological Chemistry.

[21]  S. Grinstein,et al.  Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis , 2003, The Journal of cell biology.

[22]  J. Swanson,et al.  Phosphoinositide-3-kinase-independent contractile activities associated with Fcγ-receptor-mediated phagocytosis and macropinocytosis in macrophages , 2003, Journal of Cell Science.

[23]  J. Mazurkiewicz,et al.  Differential Requirement for Classic and Novel PKC Isoforms in Respiratory Burst and Phagocytosis in RAW 264.7 Cells1 , 2000, The Journal of Immunology.

[24]  J. Swanson,et al.  Plasticity of the tubular lysosomal compartment in macrophages. , 1990, Journal of cell science.

[25]  S. Grinstein,et al.  Differential Role of Actin, Clathrin, and Dynamin in Fcγ Receptor-mediated Endocytosis and Phagocytosis* , 2003, The Journal of Biological Chemistry.

[26]  Gerra L. Bosco,et al.  Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. , 2001, Immunity.

[27]  K. Beningo,et al.  A contractile activity that closes phagosomes in macrophages. , 1999, Journal of cell science.

[28]  S. Bagrodia,et al.  Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. , 1994, The Journal of biological chemistry.

[29]  J. Freed,et al.  ADP ribosylation factor 6 binding to phosphatidylinositol 4,5-bisphosphate-containing vesicles creates defects in the bilayer structure: an electron spin resonance study. , 2001, Biophysical journal.

[30]  J. Swanson,et al.  The uniformity of phagosome maturation in macrophages , 2004, The Journal of cell biology.

[31]  David T. Jones,et al.  Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells. , 2002, Molecular biology of the cell.

[32]  Daniel Kalman,et al.  Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis , 2003, The Journal of cell biology.

[33]  A. Hall,et al.  Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3 , 2000, Nature Cell Biology.

[34]  J. Swanson,et al.  Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis. , 2004, Molecular biology of the cell.

[35]  S. Grinstein,et al.  Focal Exocytosis of Vamp3-Containing Vesicles at Sites of Phagosome Formation , 2000, The Journal of cell biology.

[36]  P. Chavrier,et al.  ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages , 2003, The Journal of cell biology.

[37]  L. Lim,et al.  A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42 , 1993, Nature.

[38]  Shaun P Jackson,et al.  Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. , 2007, The Biochemical journal.

[39]  Janet M. Allen,et al.  Crosstalk between ARF6 and protein kinase Cα in FcγRI-mediated activation of phospholipase D1 , 2001, Current Biology.