Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: formulation approach toward improved in vivo performance.
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V. Dobričić | S. Savić | D. Randjelović | P. Vulić | J. Cook | M. Savić | D. Knutson | B. Čalija | J. Mitrović | J. Đoković | B. Divović | Bojan Čalija
[1] H. Eroğlu,et al. Evaluation of improved oral bioavailability of ritonavir nanosuspension , 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[2] W. Sieghart,et al. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABAA receptors , 2019, European journal of pain.
[3] W. Sieghart,et al. The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation , 2018, Neuropharmacology.
[4] Eknath D. Ahire,et al. Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications , 2018, Acta pharmaceutica Sinica. B.
[5] W. Sieghart,et al. Cerebellar α6‐subunit‐containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders , 2018, British journal of pharmacology.
[6] W. Sieghart,et al. Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. , 2018, Journal of medicinal chemistry.
[7] Salvatore Marceddu,et al. Nile red nanosuspensions as investigative model to study the follicular targeting of drug nanocrystals. , 2017, International journal of pharmaceutics.
[8] S. Lee,et al. Development Considerations for Nanocrystal Drug Products , 2017, The AAPS Journal.
[9] Lulu Wang,et al. Safety of nanosuspensions in drug delivery. , 2017, Nanomedicine : nanotechnology, biology, and medicine.
[10] Sourav Bhattacharjee,et al. DLS and zeta potential - What they are and what they are not? , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[11] G. Boeck,et al. Development of a nanosuspension for iv administration: From miniscale screening to a freeze dried formulation. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[12] V. Nekkanti,et al. Insoluble drug delivery strategies: review of recent advances and business prospects , 2015, Acta pharmaceutica Sinica. B.
[13] Mohamad Haitham Ayad. Rational formulation strategy from drug discovery profiling to human proof of concept , 2015, Drug delivery.
[14] Rainer H Müller,et al. Effect of drug physico-chemical properties on the efficiency of top-down process and characterization of nanosuspension , 2015, Expert opinion on drug delivery.
[15] Xing Tang,et al. Investigation of a nanosuspension stabilized by Soluplus® to improve bioavailability. , 2014, International journal of pharmaceutics.
[16] William Wei Lim Chin,et al. A brief literature and patent review of nanosuspensions to a final drug product. , 2014, Journal of pharmaceutical sciences.
[17] T. Rades,et al. Refining stability and dissolution rate of amorphous drug formulations , 2014, Expert opinion on drug delivery.
[18] Ying Zheng,et al. Stability of nanosuspensions in drug delivery. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[19] A. Lundqvist,et al. Evaluation of exposure properties after injection of nanosuspensions and microsuspenions into the intraperitoneal space in rats , 2013, Drug development and industrial pharmacy.
[20] Yong Xia,et al. The Preparation and Evaluation of Water-Soluble SKLB610 Nanosuspensions with Improved Bioavailability , 2013, AAPS PharmSciTech.
[21] Jin Han,et al. Development and in vivo/in vitro evaluation of novel herpetrione nanosuspension. , 2013, International journal of pharmaceutics.
[22] Indrajit Ghosh,et al. Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[23] Hywel D Williams,et al. Strategies to Address Low Drug Solubility in Discovery and Development , 2013, Pharmacological Reviews.
[24] Wei Wu,et al. Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecipitation/homogenization based on acid-base neutralization. , 2012, International journal of pharmaceutics.
[25] Si-Shen Feng,et al. Vitamin E TPGS as a molecular biomaterial for drug delivery. , 2012, Biomaterials.
[26] P. Turner,et al. Administration of substances to laboratory animals: routes of administration and factors to consider. , 2011, Journal of the American Association for Laboratory Animal Science : JAALAS.
[27] Jian Zhang,et al. Physical and chemical stability of drug nanoparticles. , 2011, Advanced drug delivery reviews.
[28] Elaine Merisko-Liversidge,et al. Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. , 2011, Advanced drug delivery reviews.
[29] Rainer H Müller,et al. State of the art of nanocrystals--special features, production, nanotoxicology aspects and intracellular delivery. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[30] Sanjay Garg,et al. Evaluation of a crystalline nanosuspension: polymorphism, process induced transformation and in vivo studies. , 2011, International journal of pharmaceutics.
[31] N. Blagden,et al. Hydrocortisone nanosuspensions for ophthalmic delivery: A comparative study between microfluidic nanoprecipitation and wet milling. , 2011, Journal of controlled release : official journal of the Controlled Release Society.
[32] Ranjita Shegokar,et al. Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. , 2010, International journal of pharmaceutics.
[33] Aiguo Li,et al. Preparation, characterization, pharmacokinetics, and tissue distribution of curcumin nanosuspension with TPGS as stabilizer , 2010, Drug development and industrial pharmacy.
[34] Rainer H Müller,et al. Nanosuspensions: a promising formulation for the new phospholipase A2 inhibitor PX-18. , 2010, International journal of pharmaceutics.
[35] Feng Liu,et al. Understanding the structure and stability of paclitaxel nanocrystals. , 2010, International journal of pharmaceutics.
[36] B. Roth,et al. Novel positive allosteric modulators of GABAA receptors: Do subtle differences in activity at α1 plus α5 versus α2 plus α3 subunits account for dissimilarities in behavioral effects in rats? , 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[37] S. Baumgartner,et al. Advantages of celecoxib nanosuspension formulation and transformation into tablets. , 2009, International journal of pharmaceutics.
[38] Ludo Froyen,et al. A screening study of surface stabilization during the production of drug nanocrystals. , 2009, Journal of pharmaceutical sciences.
[39] Sanjay Garg,et al. Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery. , 2009, International journal of pharmaceutics.
[40] Patrick Augustijns,et al. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. , 2008, International journal of pharmaceutics.
[41] W. Sieghart,et al. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning in rats , 2008, Brain Research.
[42] Glyn Taylor,et al. The effects of pharmaceutical excipients on drug disposition. , 2007, Advanced drug delivery reviews.
[43] Daxiang Cui,et al. Study on interaction between gold nanorod and bovine serum albumin , 2007 .
[44] B. Shekunov,et al. Particle Size Analysis in Pharmaceutics: Principles, Methods and Applications , 2007, Pharmaceutical Research.
[45] S. Bates,et al. Analysis of Amorphous and Nanocrystalline Solids from Their X-Ray Diffraction Patterns , 2006, Pharmaceutical Research.
[46] B. Guth,et al. Effect of commonly used vehicles on gastrointestinal, renal, and liver function in rats. , 2006, Journal of pharmacological and toxicological methods.
[47] D. Bokonjić,et al. Benzodiazepine site inverse agonists and locomotor activity in rats: Bimodal and biphasic influence , 2006, Pharmacology Biochemistry and Behavior.
[48] N. Rasenack,et al. In vitro characterization of jet-milled and in-situ-micronized fluticasone-17-propionate. , 2003, International journal of pharmaceutics.
[49] Alexander V Kabanov,et al. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.
[50] J Verweij,et al. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. , 2001, European journal of cancer.
[51] R. Müller,et al. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. , 2001, Advanced drug delivery reviews.
[52] O. Badary,et al. Effect of Cremophor EL on the pharmacokinetics, antitumor activity and toxicity of doxorubicin in mice , 1998, Anti-cancer drugs.
[53] D. Kessel,et al. Effects of Cremophor EL on distribution of Taxol to serum lipoproteins. , 1994, British Journal of Cancer.
[54] F. Kadir,et al. Release and absorption rates of intramuscularly and subcutaneously injected pharmaceuticals (II) , 1994 .
[55] M. Shimono,et al. Effect of , 2017 .
[56] V. Claassen. Neglected factors in pharmacology and neuroscience research , 1994 .