Refining the diagnosis of hydatidiform mole: image ploidy analysis and p57KIP2 immunohistochemistry

Aim:  To determine whether image analysis of ploidy status and immunohistochemical analysis of p57KIP2 (a paternally imprinted, maternally expressed gene) can be used to refine the diagnosis of molar pregnancy.

[1]  M. Fukunaga Immunohistochemical characterization of p57(KIP2) expression in early hydatidiform moles. , 2002, Human pathology.

[2]  R. Berkowitz,et al.  Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid specimens. , 2002, The Journal of reproductive medicine.

[3]  D. Dorfman,et al.  Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classification. , 2002, The Journal of reproductive medicine.

[4]  D. Genest Partial hydatidiform mole: clinicopathological features, differential diagnosis, ploidy and molecular studies, and gold standards for diagnosis. , 2001, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[5]  S. Weremowicz,et al.  Discrimination of Complete Hydatidiform Mole From Its Mimics by Immunohistochemistry of the Paternally Imprinted Gene Product p57 KIP2 , 2001, The American journal of surgical pathology.

[6]  M. Wells,et al.  Over‐diagnosis of hydatidiform mole in early tubal ectopic pregnancy , 2001, Histopathology.

[7]  J. Sudbø,et al.  DNA content as a prognostic marker in patients with oral leukoplakia. , 2001, The New England journal of medicine.

[8]  M. Nap,et al.  Heat pretreatment increases resolution in DNA flow cytometry of paraffin-embedded tumor tissue. , 1999, Cytometry.

[9]  E. Müller-Holzner,et al.  DNA ploidy determination of early molar pregnancies by image analysis: comparison to histologic classification. , 1998, Archives of Pathology & Laboratory Medicine.

[10]  G. Mariuzzi,et al.  Differential expression of p57kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease. , 1998, Laboratory investigation; a journal of technical methods and pathology.

[11]  S S Cross,et al.  Kappa statistics as indicators of quality assurance in histopathology and cytopathology. , 1996, Journal of clinical pathology.

[12]  A. Feinberg,et al.  Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Bagg,et al.  Hydatidiform moles: DNA flow cytometry, image analysis and selected topics in molecular biology , 1996, Histopathology.

[14]  E. Newlands,et al.  A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non‐molar hydropic abortions , 1996, Histopathology.

[15]  J. Gillan,et al.  Comparison of ploidy analysis by flow cytometry and image analysis in hydatidiform mole and non‐molar abortion , 1995, Histopathology.

[16]  T. Mukai,et al.  Genomic imprinting of p57KIP2, a cyclin–dependent kinase inhibitor, in mouse , 1995, Nature Genetics.

[17]  J. Berezowsky,et al.  DNA ploidy of hydatidiform moles and nonmolar conceptuses: a study using flow and tissue section image cytometry. , 1995, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[18]  S. Hunter,et al.  Ploidy analysis of products of conception by image and flow cytometry with cytogenetic correlation. , 1995, American journal of clinical pathology.

[19]  A. Hochberg,et al.  The role of genomic imprinting in implantation. , 1994, Fertility and sterility.

[20]  A. Hochberg,et al.  Relaxation of imprinting in trophoblastic disease. , 1994, Gynecologic oncology.

[21]  S. Poppema,et al.  DNA analysis (ploidy) of molar pregnancies with image analysis on paraffin tissue sections. , 1993, American journal of clinical pathology.

[22]  A. Hanselaar,et al.  DNA cytometric and interphase cytogenetic analyses of paraffin‐embedded hydatidiform moles and hydropic abortions , 1993, The Journal of pathology.

[23]  H Fox,et al.  Can histopathologists reliably diagnose molar pregnancy? , 1993, Journal of clinical pathology.

[24]  R. Conran,et al.  Diagnostic considerations in molar gestations. , 1993, Human pathology.

[25]  R. Fisher,et al.  Genetic evidence that placental site trophoblastic tumours can originate from a hydatidiform mole or a normal conceptus. , 1992, British Journal of Cancer.

[26]  S. Lawler,et al.  Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform mole , 1990, The Lancet.

[27]  R. Berkowitz,et al.  Persistent gestational trophoblastic tumor after partial hydatidiform mole. , 1990, Gynecologic oncology.

[28]  D. Weinberg,et al.  Hydatidiform moles. Application of flow cytometry in diagnosis. , 1988, American journal of clinical pathology.

[29]  C. Elston,et al.  Diagnosis of molar pregnancy and persistent trophoblastic disease by flow cytometry. , 1987, Journal of clinical pathology.

[30]  P. Hunt,et al.  Complete and partial hydatidiform mole in Hawaii: cytogenetics, morphology and epidemiology. , 1983, British journal of obstetrics and gynaecology.

[31]  P. Jacobs,et al.  Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole , 1982, Annals of human genetics.

[32]  J. Boué,et al.  Human Triploidy: Association with Partial Hydatidiform Moles and Nonmolar Conceptuses , 1981, Human pathology.

[33]  Patricia A. Jacobs,et al.  Mechanism of origin of complete hydatidiform moles , 1980, Nature.

[34]  R. P. Smith Tubal hydatidiform mole. , 1980, IMJ. Illinois medical journal.

[35]  K. Ohama,et al.  Androgenetic origin of hydatidiform mole , 1977, Nature.

[36]  Tadashi,et al.  ANDROGENIC ORIGIN OF HYDATIDIFORM MOLE , 1977, Pediatric Research.