Comparison of 2% deoxyarbutin and 4% hydroquinone as a depigmenting agent in healthy individuals: A double‐blind randomized controlled clinical trial

Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effects. Lately, deoxyarbutin has been suggested to be an alternative of hydroquinone with better safety profile.

[1]  V. Namasivayam,et al.  Inhibitors of Melanogenesis: An Updated Review. , 2018, Journal of medicinal chemistry.

[2]  P. C. Diedrichs,et al.  Skin Color, Cultural Capital, and Beauty Products: An Investigation of the Use of Skin Fairness Products in Mumbai, India , 2018, Front. Public Health.

[3]  T. Lei,et al.  Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes , 2016, PloS one.

[4]  N. Dlova,et al.  A Fairer Face, a Fairer Tomorrow? A Review of Skin Lighteners , 2016 .

[5]  C. Couteau,et al.  Overview of Skin Whitening Agents: Drugs and Cosmetic Products , 2016 .

[6]  R. Lakhani,et al.  Correlating melanin index to repigmentation potential: A novel prognostic tool in vitiligo , 2016 .

[7]  J. O. Beer,et al.  Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe , 2016, Journal of the European Academy of Dermatology and Venereology : JEADV.

[8]  G. Degen,et al.  Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of deoxyarbutin in cosmetic products. , 2016, Regulatory toxicology and pharmacology : RTP.

[9]  B. Kasraee,et al.  Discrimination between cutaneous pigmentation and erythema: Comparison of the skin colorimeters Dermacatch and Mexameter , 2014, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[10]  M. Olsson,et al.  The melanogenesis and mechanisms of skin‐lightening agents – existing and new approaches , 2011, International journal of cosmetic science.

[11]  R. Boissy,et al.  Mechanism of tyrosinase inhibition by deoxyArbutin and its second‐generation derivatives , 2008, The British journal of dermatology.

[12]  Wen‐yuan Zhu,et al.  The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders. , 2008, The journal of investigative dermatology. Symposium proceedings.

[13]  Keyvan Nouri,et al.  The treatment of melasma: a review of clinical trials. , 2006, Journal of the American Academy of Dermatology.

[14]  J. Na,et al.  Application of a pigment measuring device – Mexameter®– for the differential diagnosis of vitiligo and nevus depigmentosus , 2006, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[15]  R. Boissy,et al.  Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent. , 2006, Journal of cosmetic science.

[16]  R. Boissy,et al.  DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency , 2005, Experimental dermatology.

[17]  Alessandra Haddad,et al.  A clinical, prospective, randomized, double‐blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasma , 2003, International journal of dermatology.

[18]  P. Clarys,et al.  Skin color measurements: comparison between three instruments: the Chromameter®, the DermaSpectrometer® and the Mexameter® , 2000, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[19]  Heinz Decker Prof.,et al.  How Does Tyrosinase Work? Recent Insights from Model Chemistry and Structural Biology , 2000 .

[20]  D. Fernandes.  Hydroquinone--a harmful agent. , 2000, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[21]  H. Glatt,et al.  Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors. , 1999, Biochemical pharmacology.

[22]  H. Hayasawa,et al.  Arbutin increases the pigmentation of cultured human melanocytes through mechanisms other than the induction of tyrosinase activity. , 1998, Pigment cell research.