미국의 내분비교란물질 규제제도로서 내분비교란물질선별제도(EDSP) 연구

There is no specific procedure for evaluating the toxic effects on the endocrine system caused by EDCs(Endocrine Disputor Chemiclas). Although it has been discussed for a long time in the world, it still has no unified view today. EDSP(Endocrine Disruptor Screening Program) in the United States are globally pioneered and systematically evaluated as a program to evaluate and regulate EDCs, so regulators and industries around the world are closely monitoring the development and development of EDSP. In this paper, I have discussed the perception of EDCs and their legal responses. and then the details of the EDSP led by the US EPA were introduced. In 1996, the US Congress initiated a response to the management and regulation of EDCs and passed the Food Quality Protection Act. In 1998, US EPA published an outline of the EDSP and investigated pesticides and chemicals. In 2009, 11 screening guidelines were enacted and the evaluation of pesticides and chemicals by EDSP was initiated. The EDSTAC(Endocrine Disruptor Screening and Testing Advisory Committee) report, which is EDSP advisory agency, proposes a two-step test design aimed at the potential evaluation by the screening test(Tier 1) and the adverse effect check by the test covering the living environment(Tier 2). This method requires a Tier 2 test if Tier 1 is estimated to have potential for endocrine disruptors. EDSP is a screening program aimed at the detection of chemical substances that have a toxic effect on endocrine system via MoA(Mechanism of Action) such as production, ecology, receptor binding or metabolism of in vivo hormone. From the perspective of risk communication, the US EDSP has very important implications. It is also important that EDSPs have a system for screening and testing EDCs, but it can provide important implications from the procedures EDSP has to ensure the confidence of risk information rather than. First, almost all chemicals are screened, except when the EPA already has sufficient qualitative information. Second, no substance is excluded or selected from screening based on existing knowledge of the potential for disturbing the endocrine system. Third, the possibility of exposure in the selection of target substances is an important basis, because the greater the likelihood that a person or organism is exposed to the substance, the greater the risk. Fourth, the validation of the test procedure is an important premise. In other words, only test methods with reliability in EDC evaluation are adopted. It is also an approach to ensure reliability in that it takes the WoE(weight of evidence) that is assessed on a scientific basis in determining the need for a Tier 2 test. Fifth, the acquisition of data is carried out by the operators who actually manufacture and distribute the chemical substances according to the test order, so that the latest adverse effect information can be obtained. And By ensuring compliance with ICR(Information Collection Request) procedures under the PRA(Paperwork Reduction Act), democracy is gaining in information gathering.