Prevention of Intraperitoneal Adhesions by Dextran, Hydrocortisone and Chymotrypsin: An Experimental Study

Abstract. The purpose of an experimental study in guineapigs was to prevent adhesion formation in the intraabdominal space by simultaneous intraperitoneal infusion of hydrocortisone, dextran and chymotrypsin. An examination made three weeks after the operation revealed a highly significant (p>0.001) difference in favour of the dextran, dextran‐chymotrypsin and dextran‐chymotrypsin‐hydrocortisone groups when compared with the NaCl and control groups.

[1]  M. Dintsman,et al.  Rheomacrodex in the prevention of intraperitoneal adhesions. Experimental work in cats. , 1972, International surgery.

[2]  S. Nummi,et al.  Conservative Operative Treatment of Tubal Pregnancy with Postoperative Daily Hydrotubations , 1972 .

[3]  S. Chatterjee.  PERITONEAL ADHESIONS , 1932, Journal of the Indian Medical Association.

[4]  W. Polishuk,et al.  Dextran in prevention of peritoneal adhesions. , 1967, Israel journal of medical sciences.

[5]  K. Swolin.  Die Einwirkung von Grossen, Intraperitonealen dosen Glukokortikoid auf die Bildung von Postoperativen Adhäsionen , 1967, Acta Obstetricia et Gynecologica Scandinavica.

[6]  T. Beretta,et al.  The effect of a fibrinolytic substance in the prevention and treatment of post-operative peritoneal adhesions. , 1966, Panminerva Medica (Testo stampato).

[7]  A. Grant,et al.  HYDROTUBATION, A METHOD OF TREATMENT FOR INFERTILITY DUE TO TUBAL DAMAGE: A REVIEW OF 327 CASES , 1966, The Medical journal of Australia.

[8]  W. D. Warren,et al.  The effect of topically applied corticosteroids in the prevention of peritoneal adhesions. An experimental approach with a review of the literature. , 1966, Surgery.

[9]  H. Fadhli,et al.  Peritoneal adhesions; prevention with povidone and dextran 75. , 1965, Archives of surgery.

[10]  J. O. Just-Viera,et al.  PREVENTION OF EXPERIMENTAL PERITONEAL ADHESIONS BY DEXTRAN. , 1964, Archives of surgery.

[11]  E. Kern,et al.  Entstehung, Klinik, Therapie und Prophylaxe der peritonealen Adhäsionen , 1964 .

[12]  G. Eskeland.  Prevention of experimental peritoneal adhesions in the rat by intraperitoneally administered corticosteroids. , 1963 .

[13]  J. Knightly,et al.  The effect of fibrinolysin and heparin on the formation of peritoneal adhesions. , 1962, Surgery.

[14]  A. Behar,et al.  Effect of fibrinolytic agents and corticosteroid hormones on peritoneal adhesions; a comparative experimental study. , 1957, A.M.A. archives of surgery.

[15]  E. Weckesser,et al.  Effect of hydrocortisone in the prevention of intraperitoneal adhesions. , 1955, A.M.A. archives of surgery.

[16]  J. Rhoads,et al.  Further Experiments on Influence of Hyaluronidase on Formation of Intraperitoneal Adhesions in the Rat , 1950, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[17]  A. Turunen.  Über den Darmverschluss als Komplikation von Krankheiten und Operationen der inneren Geburtsteile , 1932 .