Coding Region Polymorphisms of Human T‐Cell Receptor Vβ6.9 and Vβ21.4

Two new TCRVβ coding region polymorphisms were identified: Vβ6.9a/b and Vβ21.4a/b. In both cases, a single nucleotide difference gives rise to an amino acid exchange. Genomic typing by the PCR/sequence‐specific oligonucleotide probing technique was performed to study a possible contribution of these two new polymorphisms in susceptibility to autoimmune diseases. However, there was no association with insulin‐dependent diabetes mellitus, rheumatoid arthritis, juvenile rheumatoid arthritis, multiple sclerosis, myasthenia gravis or coeliac disease. On the other hand, significant differences were found between Caucasoid and Oriental populations in frequencies of the Vβ6.9 and Vβ21.4 alleles.

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