UV and visible spectrophotometric methods forthe determination of rofecoxib

UV and visible spectrophotometric methods have been developed for the determination of rofecoxib in pure and its pharmaceutical formulations. In UV method refecoxib showed absorption maximum at 285 nm. in methanol medium,where as in visible spectrophotometric method it reacts with ferric chloride and 3-Methyl-2-Benzothiazolinone hydrazone hydrochloride (MBTH) reagent and forms a green coloured chromogen having absorption maximum at 625 nm.