Epigenetics and its role in male infertility

[1]  Laurent Frésard,et al.  Epigenetics and phenotypic variability: some interesting insights from birds , 2013, Genetics Selection Evolution.

[2]  P. Jouannet,et al.  Epigenetic disorders and male subfertility. , 2013, Fertility and sterility.

[3]  M. Kumar,et al.  Novel insights into the genetic and epigenetic paternal contribution to the human embryo , 2013, Clinics.

[4]  H. Sasaki,et al.  Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development , 2012, Nucleic acids research.

[5]  A. Paradowska,et al.  Analysing the sperm epigenome: roles in early embryogenesis and assisted reproduction , 2012, Nature Reviews Urology.

[6]  Y. Kanai,et al.  DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma , 2012, Histopathology.

[7]  B. Gryder,et al.  Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed. , 2012, Future medicinal chemistry.

[8]  Yingming Zhao,et al.  Histone crotonylation specifically marks the haploid male germ cell gene expression program , 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

[9]  Zachary D. Smith,et al.  A unique regulatory phase of DNA methylation in the early mammalian embryo , 2012, Nature.

[10]  T. Hamatani.  Human spermatozoal RNAs. , 2012, Fertility and sterility.

[11]  M. Rao,et al.  Insights into Role of Bromodomain, Testis-specific (Brdt) in Acetylated Histone H4-dependent Chromatin Remodeling in Mammalian Spermiogenesis* , 2012, The Journal of Biological Chemistry.

[12]  J. Castillo,et al.  Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes. , 2011, Reproductive biomedicine online.

[13]  A. Iliadou,et al.  Epigenetics and assisted reproductive technology , 2011, Journal of internal medicine.

[14]  Zhike Lu,et al.  Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification , 2011, Cell.

[15]  P. Casson,et al.  Microarray assessment of methylation in individual mouse blastocyst stage embryos shows that in vitro culture may have widespread genomic effects. , 2011, Human reproduction.

[16]  R. Balhorn,et al.  Single molecule studies of DNA-protamine interactions. , 2011, Protein and peptide letters.

[17]  U. Maestroni,et al.  Carcinoma in situ (CIS) of the testis. , 2011, Acta bio-medica : Atenei Parmensis.

[18]  A. Agarwal,et al.  Epigenetics, spermatogenesis and male infertility. , 2011, Mutation research.

[19]  Mariana Brait,et al.  Cancer epigenetics: above and beyond , 2011, Toxicology mechanisms and methods.

[20]  M. M. Franco,et al.  Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies. , 2011, Molecular human reproduction.

[21]  B. Cairns,et al.  Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility. , 2010, Fertility and sterility.

[22]  E. Anckaert,et al.  Effects of Low Methyl Donor Levels in Culture Medium During Mouse Follicle Culture on Oocyte Imprinting Establishment1 , 2010, Biology of reproduction.

[23]  P. Arnaud.  Genomic imprinting in germ cells: imprints are under control. , 2010, Reproduction.

[24]  Liying Yan,et al.  Effects of oocyte vitrification on histone modifications. , 2010, Reproduction, fertility, and development.

[25]  Zengyan Wang,et al.  Embryo vitrification affects the methylation of the H19/Igf2 differentially methylated domain and the expression of H19 and Igf2. , 2010, Fertility and sterility.

[26]  H. Okabe,et al.  DNMT3L Is a Novel Marker and Is Essential for the Growth of Human Embryonal Carcinoma , 2010, Clinical Cancer Research.

[27]  Michael K. Skinner,et al.  Epigenetic transgenerational actions of environmental factors in disease etiology , 2010, Trends in Endocrinology & Metabolism.

[28]  H. Putter,et al.  DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. , 2009, Human molecular genetics.

[29]  M. Hanson,et al.  Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring , 2009, BMC Genomics.

[30]  R. Lambrot,et al.  The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environment , 2009, Microscopy research and technique.

[31]  J. Dadoune.  Spermatozoal RNAs: What about their functions? , 2009, Microscopy research and technique.

[32]  Robert S Illingworth,et al.  CpG islands – ‘A rough guide’ , 2009, FEBS letters.

[33]  R. Lévy,et al.  Spermiogenèse : l’acétylation des histones déclenche la reprogrammation du génome mâle , 2009 .

[34]  M. Meseguer,et al.  Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome. , 2009, Fertility and sterility.

[35]  Deliang Tang,et al.  Relation of DNA Methylation of 5′-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma , 2009, PloS one.

[36]  R. Feil,et al.  Perturbation of genomic imprinting in oligozoospermia , 2009, Epigenetics.

[37]  H. Ogi,et al.  Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. , 2008, Biochemical and biophysical research communications.

[38]  L. Looijenga,et al.  Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors , 2008, BMC Developmental Biology.

[39]  Hein Putter,et al.  Persistent epigenetic differences associated with prenatal exposure to famine in humans , 2008, Proceedings of the National Academy of Sciences.

[40]  Fernanda S. Valdovinos,et al.  Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice , 2008, BMC Physiology.

[41]  N. Yaegashi,et al.  DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm , 2008, European Journal of Human Genetics.

[42]  P. Sassone-Corsi,et al.  Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. , 2008, Developmental biology.

[43]  S. Krawetz,et al.  Paternal contributions: New functional insights for spermatozoal RNA , 2008, Journal of cellular biochemistry.

[44]  M. Surani,et al.  Chromatin dynamics during epigenetic reprogramming in the mouse germ line , 2008, Nature.

[45]  M. Lidow,et al.  Maternal Cocaine Administration in Mice Alters DNA Methylation and Gene Expression in Hippocampal Neurons of Neonatal and Prepubertal Offspring , 2008, PloS one.

[46]  M. Sousa,et al.  Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. , 2008, Molecular human reproduction.

[47]  E. Budtz-Jørgensen,et al.  Impaired Reproductive Development in Sons of Women Occupationally Exposed to Pesticides during Pregnancy , 2008, Environmental health perspectives.

[48]  George R. Douglas,et al.  Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location , 2008, Proceedings of the National Academy of Sciences.

[49]  P. Laird,et al.  Widespread Epigenetic Abnormalities Suggest a Broad DNA Methylation Erasure Defect in Abnormal Human Sperm , 2007, PloS one.

[50]  N. Yaegashi,et al.  Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. , 2007, Human molecular genetics.

[51]  C. Sette,et al.  Dynamic Regulation of Histone H3 Methylation at Lysine 4 in Mammalian Spermatogenesis1 , 2007, Biology of reproduction.

[52]  Y. Mishina,et al.  Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis , 2007, Nature.

[53]  R. Lothe,et al.  The epigenome of testicular germ cell tumors , 2007, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[54]  R. Jirtle,et al.  Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development , 2007, Proceedings of the National Academy of Sciences.

[55]  D. Smiraglia,et al.  Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells. , 2007, Developmental biology.

[56]  K. Biermann,et al.  Epigenetics in male germ cells. , 2007, Journal of andrology.

[57]  Michael J Meaney,et al.  Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. , 2007, Trends in molecular medicine.

[58]  K. Godfrey,et al.  Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications , 2007, British Journal of Nutrition.

[59]  S. Henikoff,et al.  Germline histone dynamics and epigenetics. , 2007, Current opinion in cell biology.

[60]  Takashi Ito.  Role of histone modification in chromatin dynamics. , 2007, Journal of biochemistry.

[61]  M. Fraga,et al.  The Epigenetic Basis of Twin Discordance in Age-Related Diseases , 2007, Pediatric Research.

[62]  D. Carrell,et al.  Altered protamine expression and diminished spermatogenesis: what is the link? , 2007, Human reproduction update.

[63]  T. Bestor,et al.  Epigenetic Decisions in Mammalian Germ Cells , 2007, Science.

[64]  Michael B. Stadler,et al.  Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome , 2007, Nature Genetics.

[65]  M. Surani,et al.  Genetic and Epigenetic Regulators of Pluripotency , 2007, Cell.

[66]  K. Biermann,et al.  DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer , 2007, Histochemistry and Cell Biology.

[67]  D. Smiraglia,et al.  A unique configuration of genome-wide DNA methylation patterns in the testis , 2007, Proceedings of the National Academy of Sciences.

[68]  L. Looijenga,et al.  Stem cell marker OCT3/4 in tumor biology and germ cell tumor diagnostics: history and future. , 2006, Critical reviews in oncogenesis.

[69]  W. Schulz,et al.  Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. , 2006, Biochemical pharmacology.

[70]  C. Peterson,et al.  Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability. , 2006, Fertility and sterility.

[71]  Steven Henikoff,et al.  Spreading of silent chromatin: inaction at a distance , 2006, Nature Reviews Genetics.

[72]  Sun-Chong Wang,et al.  Intra- and interindividual epigenetic variation in human germ cells. , 2006, American journal of human genetics.

[73]  Hsiao-Fang Sunny Sun,et al.  Association of DAZL haplotypes with spermatogenic failure in infertile men. , 2006, Fertility and sterility.

[74]  R. Oliva.  Protamines and male infertility. , 2006, Human reproduction update.

[75]  Rivka L. Glaser,et al.  Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[76]  R. Braun,et al.  Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia. , 2006, Developmental biology.

[77]  P. Park,et al.  Postmeiotic Sex Chromatin in the Male Germline of Mice , 2006, Current Biology.

[78]  M. Mitchell,et al.  Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. , 2006, Developmental cell.

[79]  R. Waterland,et al.  Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. , 2006, Human molecular genetics.

[80]  B. Horsthemke,et al.  Imprinting defects on human chromosome 15 , 2006, Cytogenetic and Genome Research.

[81]  D. Carrell,et al.  The effect of epigenetic sperm abnormalities on early embryogenesis. , 2006, Asian journal of andrology.

[82]  A. Bird,et al.  Genomic DNA methylation: the mark and its mediators. , 2006, Trends in biochemical sciences.

[83]  R. Yanagimachi.  Male Gamete Contributions to the Embryo , 2005, Annals of the New York Academy of Sciences.

[84]  Y. Matsui,et al.  A histone H3 methyltransferase controls epigenetic events required for meiotic prophase , 2005, Nature.

[85]  M. Meistrich,et al.  Decline in fertility of mouse sperm with abnormal chromatin during epididymal passage as revealed by ICSI. , 2005, Human reproduction.

[86]  S. Baek,et al.  Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties , 2005, Yonsei medical journal.

[87]  Carmen J. Williams,et al.  Genomic Imprinting and Assisted Reproductive Technology: Connections and Potential Risks , 2005, Seminars in reproductive medicine.

[88]  S. Krawetz.  Paternal contribution: new insights and future challenges , 2005, Nature Reviews Genetics.

[89]  S. Artan,et al.  Role of the AZFd locus in spermatogenesis. , 2005, Fertility and sterility.

[90]  Michael K. Skinner,et al.  Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility , 2005, Science.

[91]  M. Hanson,et al.  Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. , 2005, The Journal of nutrition.

[92]  A. Tsujimura,et al.  Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study. , 2005, The Journal of urology.

[93]  P. Devos,et al.  Cellular expression of protamine 1 and 2 transcripts in testicular spermatids from azoospermic men submitted to TESE-ICSI. , 2005, Molecular human reproduction.

[94]  M. Ehrlich.  The Controversial Denouement of Vertebrate DNA Methylation Research , 2005, Biochemistry (Moscow).

[95]  D. Carrell,et al.  Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males. , 2005, Human reproduction.

[96]  W. Ansorge,et al.  Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours , 2005, British Journal of Cancer.

[97]  W. Reik,et al.  Epigenetic reprogramming in mammals. , 2005, Human molecular genetics.

[98]  Paolo Sassone-Corsi,et al.  Chromatin remodelling and epigenetic features of germ cells , 2005, Nature.

[99]  A. Niveleau,et al.  Influence of global sperm DNA methylation on IVF results. , 2005, Human reproduction.

[100]  A. Gansmuller,et al.  Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[101]  Y. Matsui,et al.  Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. , 2005, Developmental biology.

[102]  Michael F. Wangler,et al.  Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. , 2005, Fertility and sterility.

[103]  C. Allegrucci,et al.  Epigenetics and the germline. , 2005, Reproduction.

[104]  J. Hoeijmakers,et al.  Silencing of Unpaired Chromatin and Histone H2A Ubiquitination in Mammalian Meiosis , 2005, Molecular and Cellular Biology.

[105]  C. Caron,et al.  Establishment of male-specific epigenetic information. , 2005, Gene.

[106]  D. Lees-Murdock,et al.  Timing of establishment of paternal methylation imprints in the mouse. , 2004, Genomics.

[107]  Ahmad M Khalil,et al.  Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[108]  M. Meistrich,et al.  Abnormalities and Reduced Reproductive Potential of Sperm from Tnp1- and Tnp2-Null Double Mutant Mice1 , 2004, Biology of reproduction.

[109]  K. Failing,et al.  In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. , 2004, Journal of andrology.

[110]  M. Bartolomei,et al.  Selective loss of imprinting in the placenta following preimplantation development in culture , 2004, Development.

[111]  I. Weaver,et al.  Epigenetic programming by maternal behavior , 2004, Nature Neuroscience.

[112]  E. Nieschlag,et al.  Reproductive functions of the ageing male. , 2004, Human reproduction update.

[113]  J. Hsu,et al.  Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. , 2004, Physiological genomics.

[114]  Peter A. Jones,et al.  Epigenetics in human disease and prospects for epigenetic therapy , 2004, Nature.

[115]  M. Sousa,et al.  Genomic imprinting in disruptive spermatogenesis , 2004, The Lancet.

[116]  M. Bartolomei,et al.  Gene-specific timing and epigenetic memory in oocyte imprinting. , 2004, Human molecular genetics.

[117]  A. Feinberg,et al.  Epigenetics and assisted reproductive technology: a call for investigation. , 2004, American journal of human genetics.

[118]  D. Elliott,et al.  Patterns, mechanisms, and functions of translation regulation in mammalian spermatogenic cells , 2004, Cytogenetic and Genome Research.

[119]  A. Feinberg,et al.  The history of cancer epigenetics , 2004, Nature Reviews Cancer.

[120]  K. Mochida,et al.  Microinsemination with first-wave round spermatids from immature male mice. , 2004, The Journal of reproduction and development.

[121]  M. Péoc'h,et al.  Misregulation of histone acetylation in Sertoli cell-only syndrome and testicular cancer. , 2003, Molecular human reproduction.

[122]  D. Burke,et al.  Age-associated activation of epigenetically repressed genes in the mouse. , 2003, Genetics.

[123]  E. Li,et al.  5-aza-2'-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome. , 2003, Journal of andrology.

[124]  A. Mclaren,et al.  Primordial germ cells in the mouse. , 2003, Developmental biology.

[125]  A. Niveleau,et al.  Quantitation by image analysis of global DNA methylation in human spermatozoa and its prognostic value in in vitro fertilization: a preliminary study. , 2003, Fertility and sterility.

[126]  A. Mafi,et al.  Effect of human sperm chromatin anomalies on fertilization outcome post‐ICSI , 2003, Andrologia.

[127]  Robert A. Waterland,et al.  Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation , 2003, Molecular and Cellular Biology.

[128]  A. Probst,et al.  Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[129]  A. Agarwal,et al.  Role of sperm chromatin abnormalities and DNA damage in male infertility. , 2003, Human reproduction update.

[130]  M. Faddy,et al.  Rare congenital disorders, imprinted genes, and assisted reproductive technology , 2003, The Lancet.

[131]  T. Jenuwein,et al.  An epigenetic road map for histone lysine methylation , 2003, Journal of Cell Science.

[132]  J. Guérin,et al.  Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. , 2003, Human reproduction.

[133]  R. Jaenisch,et al.  Induction of Tumors in Mice by Genomic Hypomethylation , 2003, Science.

[134]  A. Bird,et al.  Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals , 2003, Nature Genetics.

[135]  J. C. Barrett,et al.  Environmental Exposure, DNA Methylation, and Gene Regulation , 2003 .

[136]  V. Rakyan,et al.  Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[137]  M. Meistrich,et al.  Roles of transition nuclear proteins in spermiogenesis , 2003, Chromosoma.

[138]  J. Bender,et al.  An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation , 2002, The EMBO journal.

[139]  K. Failing,et al.  Expression of hyperacetylated histone H4 during normal and impaired human spermatogenesis , 2002, Andrologia.

[140]  Wendy Dean,et al.  Epigenetic reprogramming: Back to the beginning , 2002, Nature.

[141]  Victor V Lobanenkov,et al.  The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. , 2002, Seminars in cancer biology.

[142]  P. Khatri,et al.  Spermatozoal RNA profiles of normal fertile men , 2002, The Lancet.

[143]  E. Li.  Chromatin modification and epigenetic reprogramming in mammalian development , 2002, Nature Reviews Genetics.

[144]  M. Surani,et al.  Epigenetic reprogramming in mouse primordial germ cells , 2002, Mechanisms of Development.

[145]  B. Richardson,et al.  Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. , 2002, The Journal of nutrition.

[146]  J. K. Day,et al.  Genistein alters methylation patterns in mice. , 2002, The Journal of nutrition.

[147]  C. Plass,et al.  Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors , 2002, Oncogene.

[148]  J. J. Breen,et al.  BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[149]  E. Li,et al.  Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. , 2002, Development.

[150]  N. Ogonuki,et al.  Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. , 2002, Development.

[151]  R. Balhorn,et al.  Protamine 1: Protamine 2 stoichiometry in the sperm of eutherian mammals * , 2002, Molecular reproduction and development.

[152]  Daiya Takai,et al.  Comprehensive analysis of CpG islands in human chromosomes 21 and 22 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[153]  T. Bestor,et al.  Dnmt3L and the Establishment of Maternal Genomic Imprints , 2001, Science.

[154]  E. Selker,et al.  A histone H3 methyltransferase controls DNA methylation in Neurospora crassa , 2001, Nature.

[155]  Karl Mechtler,et al.  Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability , 2001, Cell.

[156]  W. Schulze,et al.  High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome. , 2001, Molecular human reproduction.

[157]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[158]  W. Reik,et al.  Epigenetic Reprogramming in Mammalian Development , 2001, Science.

[159]  D. Carrell,et al.  Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fertilizing capacity, and may reflect other abnormalities of spermiogenesis. , 2001, Journal of andrology.

[160]  J. McLachlan,et al.  Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. , 2001, Endocrine reviews.

[161]  W. Willis,et al.  Haploinsufficiency of protamine-1 or -2 causes infertility in mice , 2001, Nature Genetics.

[162]  P. Hunt,et al.  To err (meiotically) is human: the genesis of human aneuploidy , 2001, Nature Reviews Genetics.

[163]  B. Eskenazi,et al.  Effects of male age on semen quality and fertility: a review of the literature. , 2001, Fertility and sterility.

[164]  Y. Usson,et al.  Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone deacetylases. , 2000, European journal of cell biology.

[165]  C. Foresta,et al.  Role of the AZFa candidate genes in male infertility , 2000, Journal of endocrinological investigation.

[166]  S. Gilbert,et al.  Embracing complexity: Organicism for the 21st century , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

[167]  E. Silbergeld,et al.  Lead effects on protamine-DNA binding. , 2000, American journal of industrial medicine.

[168]  A. Means,et al.  Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4 , 2000, Nature Genetics.

[169]  Y. Hayashizaki,et al.  The paternal methylation imprint of the mouse H19 locus is acquired in the gonocyte stage during foetal testis development , 2000, Genes to cells : devoted to molecular & cellular mechanisms.

[170]  A. Means,et al.  Ca2+/Calmodulin-dependent Protein Kinase IV Is Expressed in Spermatids and Targeted to Chromatin and the Nuclear Matrix* , 2000, The Journal of Biological Chemistry.

[171]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[172]  A. Bird,et al.  DNA methylation and chromatin modification. , 1999, Current opinion in genetics & development.

[173]  J. Hoeijmakers,et al.  Histone ubiquitination and chromatin remodeling in mouse spermatogenesis. , 1999, Developmental biology.

[174]  D. Carrell,et al.  Characterization of aneuploidy rates, protamine levels, ultrastructure, and functional ability of round-headed sperm from two siblings and implications for intracytoplasmic sperm injection. , 1999, Fertility and sterility.

[175]  Y. Kim,et al.  Folate and carcinogenesis: evidence, mechanisms, and implications. , 1999, The Journal of nutritional biochemistry.

[176]  S. Tilghman.  The Sins of the Fathers and Mothers Genomic Imprinting in Mammalian Development , 1999, Cell.

[177]  M D Johnson,et al.  Genetic risks of intracytoplasmic sperm injection in the treatment of male infertility: recommendations for genetic counseling and screening. , 1998, Fertility and sterility.

[178]  R. Kodell,et al.  Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[179]  E. Li,et al.  Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases , 1998, Nature Genetics.

[180]  T. Bestor.  Cytosine methylation and the unequal developmental potentials of the oocyte and sperm genomes. , 1998, American journal of human genetics.

[181]  J. Grootegoed,et al.  Immunoexpression of testis-specific histone 2B in human spermatozoa and testis tissue. , 1998, Human reproduction.

[182]  J. Renard,et al.  Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos. , 1997, Development.

[183]  R. Motzer,et al.  Testicular germ-cell cancer. , 1997, The New England journal of medicine.

[184]  A. V. van Bergen,et al.  Microdeletions in the Y chromosome of infertile men. , 1997, The New England journal of medicine.

[185]  A. Edelmann,et al.  Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. , 1996, Human molecular genetics.

[186]  D. Sheehan,et al.  Methylation Profile and Amplification of Proto-Oncogenes in Rat Pancreas Induced with Phytoestrogens , 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[187]  H. Cedar,et al.  Role of DNA methylation in the regulation of transcription. , 1994, Current opinion in genetics & development.

[188]  A. Tomilin,et al.  Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin , 1993, Molecular reproduction and development.

[189]  T. Bestor,et al.  Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. , 1992, The EMBO journal.

[190]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[191]  C. Allis,et al.  Highly acetylated H4 is associated with histone displacement in rat spermatids , 1992, Molecular reproduction and development.

[192]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[193]  N. Tanphaichitr,et al.  Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males , 1988, Experientia.

[194]  P. Jouannet,et al.  ANOMALOUS PROTEIN COMPLEMENT OF SPERM NUCLEI IN SOME INFERTILE MEN , 1987, The Lancet.

[195]  C. Schmid,et al.  Sequence-specific packaging of DNA in human sperm chromatin. , 1987, Science.

[196]  V. L. Wilson,et al.  DNA methylation decreases in aging but not in immortal cells. , 1983, Science.

[197]  A. Feinberg,et al.  Hypomethylation distinguishes genes of some human cancers from their normal counterparts , 1983, Nature.

[198]  C. Waddington.  Canalization of Development and the Inheritance of Acquired Characters , 1942, Nature.

[199]  D. Carrell,et al.  The paternal epigenome and embryogenesis: poising mechanisms for development. , 2011, Asian journal of andrology.

[200]  Hélène Jammes,et al.  Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men , 2010, European Journal of Human Genetics.

[201]  D. Carrell,et al.  The human sperm epigenome and its potential role in embryonic development. , 2010, Molecular human reproduction.

[202]  Yuko Ito,et al.  Trends in Recent Research of Epigenetics, a Biological Mechanism that Regulates Gene Expression , 2009 .

[203]  M. Gerstein,et al.  RNA-Seq: a revolutionary tool for transcriptomics , 2009, Nature Reviews Genetics.

[204]  Jahnvi Pflueger,et al.  Distinctive chromatin in human sperm packages genes for embryo development , 2009 .

[205]  D. Carrell.  Contributions of spermatozoa to embryogenesis: assays to evaluate their genetic and epigenetic fitness. , 2008, Reproductive biomedicine online.

[206]  K. Singh,et al.  Genetic and epigenetic changes induced by chronic low dose exposure to arsenic of mouse testicular Leydig cells. , 2007, International journal of oncology.

[207]  C. Caron,et al.  Histone acetylation-mediated chromatin compaction during mouse spermatogenesis. , 2006, Ernst Schering Research Foundation workshop.

[208]  Xu Ma,et al.  A differentially methylated region of the DAZ1 gene in spermatic and somatic cells. , 2006, Asian journal of andrology.

[209]  T. Spector,et al.  From The Cover : Epigenetic differences arise during the lifetime of monozygotic twins , 2005 .

[210]  R. Waterland,et al.  Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. , 2004, Nutrition.

[211]  H. Sasaki,et al.  Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma. , 2004, DNA research : an international journal for rapid publication of reports on genes and genomes.

[212]  S. Tilghman,et al.  CTCF maintains differential methylation at the Igf2/H19 locus , 2003, Nature Genetics.

[213]  Xiangyi Lu,et al.  Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution , 2003, Nature Genetics.

[214]  Wendy Dean,et al.  Dynamic reprogramming of DNA methylation in the early mouse embryo. , 2002, Developmental biology.

[215]  C. S. Yang,et al.  Inhibition of carcinogenesis by dietary polyphenolic compounds. , 2001, Annual review of nutrition.

[216]  Issa Jp.  CpG-island methylation in aging and cancer. , 2000 .

[217]  G. Schatten,et al.  Paternal contributions to the mammalian zygote: fertilization after sperm-egg fusion. , 2000, International Review of Cytology.

[218]  J. Kirz,et al.  Protamine Mediated Condensation of DNA in Mammalian Sperm , 1999 .

[219]  H. Tournaye,et al.  Cytogenetics of infertile men. , 1996, Human reproduction.

[220]  C. Wylie.  Primordial germ cells , 1980, Nature.

[221]  Helmut Gernsheim,et al.  W. H. Fox Talbot and the history of photography , 1977 .