Cholecystokinin as a physiological regulator of gastric acid secretion in man

It was noted in 1928 that a duodenal factor, cholecystokinin (CCK) contracts the gallbladder. Pancreatic enzyme release by a duodenal hormone was reported in 1943, but it was only in 1966 that Jorpes & Mutt discovered that one hormone was responsible for both of these effects [l]. Exogenous CCK also has several other effects including release of the regulatory peptides, pancreatic polypeptide and somatostatin. Curiously, exogenous CCK either increased or decreased gastric acid secretion, under different conditons. Studies based on hormone infusions could not take this further, or address local effects of hormones within organs and tissues which were highlighted when CCK was found in the brain and enteric nerves.

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