Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)

Although hemispheric surgeries are among the most effective procedures for drug‐resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1‐, 2‐, and 5‐years post‐hemispherectomy.

[1]  W. Vandertop,et al.  FUSE-ML: development and external validation of a clinical prediction model for mid-term outcomes after lumbar spinal fusion for degenerative disease , 2022, European Spine Journal.

[2]  Xinting Wei,et al.  Online calculator to predict early mortality in patient with surgically treated recurrent lower-grade glioma , 2022, BMC cancer.

[3]  B. Rydenhag Children with contralateral or bilateral electroencephalogram epileptiform activity should not be excluded from hemispherectomy , 2021, Developmental medicine and child neurology.

[4]  J. Ojemann,et al.  Pediatric hemispherectomy outcome: Adaptive functioning, intelligence, and memory , 2021, Epilepsy & Behavior.

[5]  M. Smyth,et al.  Comparison of the real‐world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug‐resistant epilepsy: A post hoc analysis of the HOPS study , 2021, Epilepsia.

[6]  J. Ojemann,et al.  Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool , 2021, Epilepsia.

[7]  Adham M. Khalafallah,et al.  Predictive Model and Online Calculator for Discharge Disposition in Brain Tumor Patients. , 2020, World neurosurgery.

[8]  Nilesh S. Kurwale,et al.  Failed hemispherotomy: Insights from our early experience in 40 patients. , 2020, World neurosurgery.

[9]  Adham M. Khalafallah,et al.  A novel online calculator predicting short-term postoperative outcomes in patients with metastatic brain tumors , 2020, Journal of Neuro-Oncology.

[10]  J. Sarnthein,et al.  Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery. , 2020, Journal of neurosurgery.

[11]  P. Jayakar,et al.  Functional hemispherectomy: can preoperative imaging predict outcome? , 2020, Journal of neurosurgery. Pediatrics.

[12]  Jeremy T. Moreau,et al.  Individual-patient prediction of meningioma malignancy and survival using the Surveillance, Epidemiology, and End Results database , 2020, npj Digital Medicine.

[13]  Patrick C. Staples,et al.  An Online Calculator for the Prediction of Survival in Glioblastoma Patients Using Classical Statistics and Machine Learning , 2019, Neurosurgery.

[14]  G. Ibrahim,et al.  Resective epilepsy surgery involving eloquent cortex in the age of responsive neurostimulation: A value-based decision-making framework , 2019, Epilepsy & Behavior.

[15]  Hester F. Lingsma,et al.  Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study , 2018, British Medical Journal.

[16]  Sherri Rose,et al.  Limitations of P-Values and R-squared for Stepwise Regression Building: A Fairness Demonstration in Health Policy Risk Adjustment , 2018, American Statistician.

[17]  Per Winkel,et al.  When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts , 2017, BMC Medical Research Methodology.

[18]  Thomas A. Gerds,et al.  riskRegression: Predicting the Risk of an Event using Cox Regression Models , 2017, R J..

[19]  Jian-Guo Zhang,et al.  Hemispheric surgery for refractory epilepsy: a systematic review and meta-analysis with emphasis on seizure predictors and outcomes. , 2016, Journal of neurosurgery.

[20]  R. Flink,et al.  Complications of epilepsy surgery in Sweden 1996-2010: a prospective, population-based study. , 2015, Journal of neurosurgery.

[21]  W. Bingaman,et al.  Longitudinal seizure outcome and prognostic predictors after hemispherectomy in 170 children , 2013, Neurology.

[22]  M. Smyth,et al.  Palliative hemispherotomy in children with bilateral seizure onset. , 2012, Journal of neurosurgery. Pediatrics.

[23]  P. Gosselaar,et al.  Contralateral MRI abnormalities affect seizure and cognitive outcome after hemispherectomy , 2010, Neurology.

[24]  J. Ojemann,et al.  Hemispherotomy: efficacy and analysis of seizure recurrence. , 2009, Journal of neurosurgery. Pediatrics.

[25]  Juan Lu,et al.  Predicting Outcome after Traumatic Brain Injury: Development and International Validation of Prognostic Scores Based on Admission Characteristics , 2008, PLoS medicine.

[26]  E Wyllie,et al.  Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings , 2007, Neurology.

[27]  David Araújo,et al.  Outcome of hemispheric surgeries for refractory epilepsy in pediatric patients , 2007, Child's Nervous System.

[28]  C. Cepeda,et al.  Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly. , 2006, Brain : a journal of neurology.

[29]  H. Lüders,et al.  Seizure outcome after epilepsy surgery in patients with normal preoperative MRI , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[30]  J M Freeman,et al.  Hemispherectomy for intractable unihemispheric epilepsy Etiology vs outcome , 2003, Neurology.

[31]  F. Vargha-Khadem,et al.  Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence. , 2003, Brain : a journal of neurology.

[32]  E. Kossoff,et al.  The Postoperative Course and Management of 106 Hemidecortications , 2002, Pediatric Neurosurgery.

[33]  W. Peacock,et al.  Disconnective Hemispherectomy , 2001, Pediatric Neurosurgery.

[34]  J.P.L. Brand,et al.  Development, Implementation and Evaluation of Multiple Imputation Strategies for the Statistical Analysis of Incomplete Data Sets , 1999 .

[35]  H. Vinters,et al.  Hemispherectomy for intractable seizures in children: a report of 58 cases , 1996, Child's Nervous System.

[36]  T. Törmä,et al.  HEMISPHERECTOMY IN EARLY HEMIPLEGIA AND INTRACTABLE EPILEPSY , 1971, Acta paediatrica Scandinavica.

[37]  Lena Osterhagen,et al.  Multiple Imputation For Nonresponse In Surveys , 2016 .

[38]  P. Winkler,et al.  Hemispherectomy for treatment of refractory epilepsy in the pediatric age group: a systematic review. , 2015, Journal of neurosurgery. Pediatrics.