Automatic Glaucoma Detection Method Applying a Statistical Approach to Fundus Images

Objectives Glaucoma is an incurable eye disease and the second leading cause of blindness in the world. Until 2020, the number of patients of this disease is estimated to increase. This paper proposes a glaucoma detection method using statistical features and the k-nearest neighbor algorithm as the classifier. Methods We propose three statistical features, namely, the mean, smoothness and 3rd moment, which are extracted from images of the optic nerve head. These three features are obtained through feature extraction followed by feature selection using the correlation feature selection method. To classify those features, we apply the k-nearest neighbor algorithm as a classifier to perform glaucoma detection on fundus images. Results To evaluate the performance of the proposed method, 84 fundus images were used as experimental data consisting of 41 glaucoma image and 43 normal images. The performance of our proposed method was measured in terms of accuracy, and the overall result achieved in this work was 95.24%, respectively. Conclusions This research showed that the proposed method using three statistics features achieves good performance for glaucoma detection.

[1]  Agus Harjoko,et al.  Optic disc and cup segmentation by automatic thresholding with morphological operation for glaucoma evaluation , 2017, Signal Image Video Process..

[2]  Malay Kishore Dutta,et al.  An adaptive threshold based image processing technique for improved glaucoma detection and classification , 2015, Comput. Methods Programs Biomed..

[3]  Agus Harjoko,et al.  Automated Detection of Retinal Nerve Fiber Layer by Texture-Based Analysis for Glaucoma Evaluation , 2018, Healthcare informatics research.

[4]  N. Rengarajan,et al.  PERFORMANCE ANALYSIS OF GRAY LEVEL CO-OCCURRENCE MATRIX TEXTURE FEATURES FOR GLAUCOMA DIAGNOSIS , 2014 .

[5]  Tien Yin Wong,et al.  Superpixel Classification Based Optic Disc and Optic Cup Segmentation for Glaucoma Screening , 2013, IEEE Transactions on Medical Imaging.

[6]  Farida Cheriet,et al.  Glaucoma detection based on local binary patterns in fundus photographs , 2014, Medical Imaging.

[7]  Kevin Noronha,et al.  Biomedical Signal Processing and Control Automated Classification of Glaucoma Stages Using Higher Order Cumulant Features , 2022 .

[8]  Jacob Scharcanski,et al.  A morphologic two-stage approach for automated optic disk detection in color eye fundus images , 2013, Pattern Recognit. Lett..

[9]  Elijah Blessing Rajsingh,et al.  An empirical study on optic disc segmentation using an active contour model , 2015, Biomed. Signal Process. Control..

[10]  Carlo Traverso,et al.  Atlas of glaucoma , 2014 .

[11]  A. MURTHI,et al.  MEDICAL DECISION SUPPORT SYSTEM TO IDENTIFY GLAUCOMA USING CUP TO DISC RATIO 1 , 2014 .

[12]  Noor Elaiza Abdul Khalid,et al.  Fuzzy c-Means (FCM) for Optic Cup and Disc Segmentation with Morphological Operation , 2014 .

[13]  Hari Kusnanto,et al.  Interpretation of Clinical Data Based on C4.5 Algorithm for the Diagnosis of Coronary Heart Disease , 2016, Healthcare informatics research.

[14]  ANINDITA SEPTIARINI,et al.  AUTOMATIC GLAUCOMA DETECTION BASED ON THE TYPE OF FEATURES USED : A REVIEW 1 , 2015 .

[15]  H. Quigley Number of people with glaucoma worldwide. , 1996, The British journal of ophthalmology.

[16]  Judith Justin,et al.  Classification of Glaucoma Images using Wavelet based Energy Features and PCA , 2013 .

[17]  M. Usman Akram,et al.  Automated detection of glaucoma using structural and non structural features , 2016, SpringerPlus.

[18]  Anushikha Singh,et al.  Image processing based automatic diagnosis of glaucoma using wavelet features of segmented optic disc from fundus image , 2016, Comput. Methods Programs Biomed..

[19]  Tzyy-Ping Jung,et al.  Glaucoma Progression Detection Using Structural Retinal Nerve Fiber Layer Measurements and Functional Visual Field Points , 2014, IEEE Transactions on Biomedical Engineering.

[20]  Pedro Larrañaga,et al.  A review of feature selection techniques in bioinformatics , 2007, Bioinform..

[21]  Hiroshi Fujita,et al.  Automated segmentation of optic disc region on retinal fundus photographs: Comparison of contour modeling and pixel classification methods , 2011, Comput. Methods Programs Biomed..

[22]  I. Marjanovic,et al.  The Optic Nerve in Glaucoma , 2011 .

[23]  Lloyd A. Smith,et al.  Feature Selection for Machine Learning: Comparing a Correlation-Based Filter Approach to the Wrapper , 1999, FLAIRS.

[24]  José Manuel Bravo,et al.  Obtaining optic disc center and pixel region by automatic thresholding methods on morphologically processed fundus images , 2015, Comput. Methods Programs Biomed..

[25]  H. Quigley,et al.  The number of people with glaucoma worldwide in 2010 and 2020 , 2006, British Journal of Ophthalmology.

[26]  U. Rajendra Acharya,et al.  Data mining technique for automated diagnosis of glaucoma using higher order spectra and wavelet energy features , 2012, Knowl. Based Syst..

[27]  Abhishek Dey,et al.  Automated Glaucoma Detection Using Support Vector Machine Classification Method. , 2016 .

[28]  A. Kandaswamy,et al.  Breast Tissue Classification Using Statistical Feature Extraction Of Mammograms , 2006 .

[29]  K. Ramesh Kumar,et al.  Analysis of Feature Selection Algorithms on Classification: A Survey , 2014 .

[30]  Anindita Septiarini,et al.  TURNITIN - The Contour Extraction of Cup in Fundus Images for Glaucoma Detection , 2019 .

[31]  Dat Tran,et al.  Hybrid Approach for Diagnosing Thyroid, Hepatitis, and Breast Cancer Based on Correlation Based Feature Selection and Naïve Bayes , 2012, ICONIP.

[32]  Jaebum Son,et al.  The Recent Progress in Quantitative Medical Image Analysis for Computer Aided Diagnosis Systems , 2011, Healthcare informatics research.

[33]  Sotiris B. Kotsiantis,et al.  Supervised Machine Learning: A Review of Classification Techniques , 2007, Informatica.

[34]  Goutam Sanyal,et al.  Automated Glaucoma Screening in Retinal Fundus Images , 2015, MUE 2015.