Stemming retinal regeneration with pluripotent stem cells

[1]  H. Sakaguchi,et al.  A Strategy for Personalized Treatment of iPS-Retinal Immune Rejections Assessed in Cynomolgus Monkey Models , 2020, International journal of molecular sciences.

[2]  G. Bewick,et al.  Diabetes through a 3D lens: organoid models , 2020, Diabetologia.

[3]  Zi-Bing Jin,et al.  Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa , 2020, Frontiers in Cell and Developmental Biology.

[4]  B. Roska,et al.  The primate model for understanding and restoring vision , 2019, Proceedings of the National Academy of Sciences.

[5]  Ross A. Poché,et al.  Awakening the regenerative potential of the mammalian retina , 2019, Development.

[6]  Yvonne Hsu-Lin Luo,et al.  The Argus II Retinal Prosthesis System , 2019, Prosthesis.

[7]  Peng Jiang,et al.  Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells , 2018, Stem cell reports.

[8]  Adnan Tufail,et al.  Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration , 2018, Nature Biotechnology.

[9]  T. Xue,et al.  Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients , 2018, Stem cell reports.

[10]  V. Wallace,et al.  Material Exchange in Photoreceptor Transplantation: Updating Our Understanding of Donor/Host Communication and the Future of Cell Engraftment Science , 2018, Front. Neural Circuits.

[11]  Genshiro A. Sunagawa,et al.  Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation , 2018, Stem cell reports.

[12]  Emily Welby,et al.  Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell‐Derived Retinal Organoids and Fetal Retinae , 2018, Stem cells.

[13]  Anna B. Graca,et al.  Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner , 2018, Stem cell reports.

[14]  Vijender Chaitankar,et al.  Molecular Anatomy of the Developing Human Retina. , 2017, Developmental cell.

[15]  T. Shiina,et al.  Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models , 2017, Stem cell reports.

[16]  Yong Liu,et al.  Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients , 2017, Stem Cell Research & Therapy.

[17]  G. Daley,et al.  Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[18]  H. Dou,et al.  A comparison of autologous transplantation of retinal pigment epithelium (RPE) monolayer sheet graft with RPE–Bruch's membrane complex graft in neovascular age‐related macular degeneration , 2017, Acta ophthalmologica.

[19]  Adam P. DeLuca,et al.  Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease. , 2017, Ophthalmology.

[20]  Akihito Uji,et al.  Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration. , 2017, Investigative ophthalmology & visual science.

[21]  H. Onoe,et al.  MHC matching improves engraftment of iPSC-derived neurons in non-human primates , 2017, Nature Communications.

[22]  F. Rieke,et al.  Stimulation of functional neuronal regeneration from Müller glia in adult mice , 2017, Nature.

[23]  K. Nagashima,et al.  In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations. , 2017, Cell reports.

[24]  Timothy A. Blenkinsop,et al.  The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue , 2017, Stem cell reports.

[25]  Kathleen A. Marshall,et al.  The Role of the Human Visual Cortex in Assessment of the Long-Term Durability of Retinal Gene Therapy in Follow-on RPE65 Clinical Trial Patients. , 2017, Ophthalmology.

[26]  E. L. West,et al.  Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration , 2017, Stem cell reports.

[27]  A. Messias,et al.  Intravitreal use of bone marrow mononuclear fraction containing CD34+ stem cells in patients with atrophic age-related macular degeneration , 2017, Clinical ophthalmology.

[28]  R. Wilson,et al.  The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis , 2017, Neuron.

[29]  José-Alain Sahel,et al.  Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno‐Free and Feeder‐Free Conditions , 2017, Stem cells.

[30]  Zhigang Fan,et al.  HiPSC-derived retinal ganglion cells grow dendritic arbors and functional axons on a tissue-engineered scaffold. , 2017, Acta biomaterialia.

[31]  John M. Ball,et al.  Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells , 2017, Scientific Reports.

[32]  V. Wallace,et al.  A Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors , 2017, Stem cells.

[33]  Ajay E. Kuriyan,et al.  Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD. , 2017, The New England journal of medicine.

[34]  Takashi Daimon,et al.  Autologous Induced Stem‐Cell–Derived Retinal Cells for Macular Degeneration: Brief Report , 2017, The New England journal of medicine.

[35]  Vijender Chaitankar,et al.  Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice , 2017, Nature Communications.

[36]  D. Lamba,et al.  Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina. , 2017, Cell stem cell.

[37]  Dong Ryul Lee,et al.  Survival of Transplanted Human Embryonic Stem Cell–Derived Retinal Pigment Epithelial Cells in a Human Recipient for 22 Months , 2017, JAMA ophthalmology.

[38]  Genshiro A. Sunagawa,et al.  iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice , 2017, Stem cell reports.

[39]  Feng Gu,et al.  Toll-Like Receptor 3 Activation Initiates Photoreceptor Cell Death In Vivo and In Vitro. , 2017, Investigative ophthalmology & visual science.

[40]  M. Samardzija,et al.  Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[41]  R. MacLaren,et al.  Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion , 2016, Nature Communications.

[42]  H. Tse,et al.  Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage , 2016, Cell Death & Disease.

[43]  Adam S. Wenick,et al.  Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration. , 2016, JAMA ophthalmology.

[44]  E. L. West,et al.  Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors , 2016, Nature Communications.

[45]  M. Ader,et al.  Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange , 2016, Nature Communications.

[46]  S. Benes,et al.  Stem Cell Ophthalmology Treatment Study (SCOTS): bone marrow-derived stem cells in the treatment of Leber's hereditary optic neuropathy , 2016, Neural regeneration research.

[47]  J. Duncan,et al.  Long-term Follow-up of Patients With Retinitis Pigmentosa Receiving Intraocular Ciliary Neurotrophic Factor Implants. , 2016, American journal of ophthalmology.

[48]  Masayo Takahashi,et al.  Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors , 2016, Stem cell reports.

[49]  T. Shiina,et al.  Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models , 2016, Stem cell reports.

[50]  Cassie A. Ludwig,et al.  Retinotomy Closure Following Subretinal Stem Cell Transplant With a 30-Gauge Needle. , 2016, Ophthalmic surgery, lasers & imaging retina.

[51]  S. Benes,et al.  Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment , 2016, Neural regeneration research.

[52]  Kathleen A. Marshall,et al.  Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial , 2016, The Lancet.

[53]  E. Stone,et al.  Results of phase III clinical trial subretinal gene therapy for RPE65-mediated Leber congenital amaurosis (LCA) , 2016 .

[54]  Kyoko Ohno-Matsui,et al.  Differentiation/Purification Protocol for Retinal Pigment Epithelium from Mouse Induced Pluripotent Stem Cells as a Research Tool , 2016, PloS one.

[55]  M. Berry,et al.  Dental pulp stem cells: a novel cell therapy for retinal and central nervous system repair , 2016 .

[56]  Yu Zhang,et al.  Conversion of human fibroblasts into functional cardiomyocytes by small molecules , 2016, Science.

[57]  Peter M. G. Munro,et al.  Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups , 2016, Cell stem cell.

[58]  T. Yokoi,et al.  Generation of Retinal Ganglion Cells With Functional Axons From Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells. , 2016, Investigative ophthalmology & visual science.

[59]  Jiashun Zheng,et al.  Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. , 2016, Cell stem cell.

[60]  A. Cvekl,et al.  Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid , 2016, Stem cell reports.

[61]  Volker Busskamp,et al.  Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis , 2016, Stem cell reports.

[62]  G. A. Limb,et al.  Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion , 2015, Stem cells translational medicine.

[63]  M. Eiraku,et al.  Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration , 2015, Proceedings of the National Academy of Sciences.

[64]  Joshua J. Breunig,et al.  In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[65]  Bing Huang,et al.  The immune response of stem cells in subretinal transplantation , 2015, Stem Cell Research & Therapy.

[66]  S. Benes,et al.  Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a case report of improvement in relapsing auto-immune optic neuropathy , 2015, Neural regeneration research.

[67]  Koray D. Kaya,et al.  Transcriptome Dynamics of Developing Photoreceptors in Three‐Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks , 2015, Stem cells.

[68]  Alex Gutteridge,et al.  Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation , 2015, Stem cells.

[69]  J. Sunness.  Stem cells in age-related macular degeneration and Stargardt's macular dystrophy , 2015, The Lancet.

[70]  J. Weiss,et al.  Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report , 2015, Neural regeneration research.

[71]  E. L. West,et al.  Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell‐Derived Self‐Forming Retina , 2015, Stem cells.

[72]  G. Duruksu,et al.  Neuroprotective effects of intravitreally transplanted adipose tissue and bone marrow-derived mesenchymal stem cells in an experimental ocular hypertension model. , 2015, Cytotherapy.

[73]  M. Mandai,et al.  Protective Effects of Human iPS‐Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 mice , 2015, Stem cells.

[74]  L. D. Del Priore,et al.  Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients , 2015, Stem cell reports.

[75]  M. Eiraku,et al.  Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells , 2015, Current eye research.

[76]  A. Messias,et al.  Quality of life in patients with retinitis pigmentosa submitted to intravitreal use of bone marrow-derived stem cells (Reticell -clinical trial) , 2015, Stem Cell Research & Therapy.

[77]  Edwin M. Stone,et al.  Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy , 2015, Progress in Retinal and Eye Research.

[78]  A. Messias,et al.  Improvement of ischaemic macular oedema after intravitreal injection of autologous bone marrow‐derived haematopoietic stem cells , 2015, Acta ophthalmologica.

[79]  Y. Sasai,et al.  Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue , 2015, Nature Communications.

[80]  Tadashi Yokoi,et al.  Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells , 2015, Scientific Reports.

[81]  P. Rosenfeld,et al.  Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies , 2015, The Lancet.

[82]  Hongkui Deng,et al.  Direct lineage reprogramming: strategies, mechanisms, and applications. , 2015, Cell stem cell.

[83]  Zi-Bing Jin,et al.  Identification of false-negative mutations missed by next-generation sequencing in retinitis pigmentosa patients: a complementary approach to clinical genetic diagnostic testing , 2015, Genetics in Medicine.

[84]  Masayo Takahashi,et al.  Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products , 2015, Journal of clinical medicine.

[85]  Aijun Wang,et al.  A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. , 2014, Biomaterials.

[86]  C. Pang,et al.  Genotype–phenotype correlation and mutation spectrum in a large cohort of patients with inherited retinal dystrophy revealed by next-generation sequencing , 2014, Genetics in Medicine.

[87]  E. Stone,et al.  The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. , 2014, The American journal of pathology.

[88]  D. Cyranoski.  Japanese woman is first recipient of next-generation stem cells , 2014, Nature.

[89]  C. Cepko.  Intrinsically different retinal progenitor cells produce specific types of progeny , 2014, Nature Reviews Neuroscience.

[90]  Nicholas A. Kouris,et al.  Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties. , 2014, Stem cells and development.

[91]  A. Hewitt,et al.  Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells. , 2014, Translational vision science & technology.

[92]  Qi Liu,et al.  ‘RetinoGenetics’: a comprehensive mutation database for genes related to inherited retinal degeneration , 2014, Database J. Biol. Databases Curation.

[93]  Elias T. Zambidis,et al.  Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs , 2014, Nature Communications.

[94]  R. A. Pearson,et al.  Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. , 2014, Stem cells and development.

[95]  Chikako Yamada,et al.  Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice , 2014, Stem cell reports.

[96]  Jinyu Wu,et al.  SLC7A14 linked to autosomal recessive retinitis pigmentosa , 2014, Nature Communications.

[97]  F. Holz,et al.  Enhancement of retinal pigment epithelial culture characteristics and subretinal space tolerance of scaffolds with 200 nm fiber topography. , 2014, Biomaterials.

[98]  R. Klein,et al.  Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. , 2014, The Lancet. Global health.

[99]  M. Mandai,et al.  Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application , 2014, Stem cell reports.

[100]  M. Mandai,et al.  Tumorigenicity Studies of Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Pigment Epithelium (RPE) for the Treatment of Age-Related Macular Degeneration , 2014, PloS one.

[101]  P. Warnke,et al.  Primordium of an artificial Bruch's membrane made of nanofibers for engineering of retinal pigment epithelium cell monolayers. , 2013, Acta biomaterialia.

[102]  G. Lynch,et al.  Chemically Induced Specification of Retinal Ganglion Cells From Human Embryonic and Induced Pluripotent Stem Cells , 2013, Stem cells translational medicine.

[103]  H. Cui,et al.  Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma , 2013, Clinical interventions in aging.

[104]  K. Palczewski,et al.  Retinal Pigmented Epithelial Cells Obtained from Human Induced Pluripotent Stem Cells Possess Functional Visual Cycle Enzymes in Vitro and in Vivo* , 2013, The Journal of Biological Chemistry.

[105]  Nicholas G Martin,et al.  Toward the development of a global induced pluripotent stem cell library. , 2013, Cell stem cell.

[106]  T. Braun,et al.  Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa , 2013, eLife.

[107]  Joan W. Miller,et al.  Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration , 2013, Cell Death and Differentiation.

[108]  H. Deng,et al.  Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds , 2013, Science.

[109]  R. Zawadzki,et al.  Optical imaging of the chorioretinal vasculature in the living human eye , 2013, Proceedings of the National Academy of Sciences.

[110]  A. Ahuja,et al.  Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. , 2013, Investigative ophthalmology & visual science.

[111]  Livia S. Carvalho,et al.  Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina , 2013, Nature Biotechnology.

[112]  A. Swaroop,et al.  Developing Rods Transplanted into the Degenerating Retina of Crx‐Knockout Mice Exhibit Neural Activity Similar to Native Photoreceptors , 2013, Stem cells.

[113]  A. Messias,et al.  Resolution of macular oedema associated with retinitis pigmentosa after intravitreal use of autologous BM-derived hematopoietic stem cell transplantation , 2013, Bone Marrow Transplantation.

[114]  Jessy D. Dorn,et al.  The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss , 2013, British Journal of Ophthalmology.

[115]  C. Curcio,et al.  SUBRETINAL DRUSENOID DEPOSITS IN NON-NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Morphology, Prevalence, Topography, and Biogenesis Model , 2013, Retina.

[116]  Peter Charbel Issa,et al.  Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation , 2013, Proceedings of the National Academy of Sciences.

[117]  E. L. West,et al.  Repair of the degenerate retina by photoreceptor transplantation , 2012, Proceedings of the National Academy of Sciences.

[118]  Weng Tao,et al.  Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases. , 2012, Investigative ophthalmology & visual science.

[119]  R. Aramant,et al.  Cell replacement and visual restoration by retinal sheet transplants , 2012, Progress in Retinal and Eye Research.

[120]  E. L. West,et al.  Defining the Integration Capacity of Embryonic Stem Cell‐Derived Photoreceptor Precursors , 2012, Stem cells.

[121]  Yoshiki Sasai,et al.  Self-formation of optic cups and storable stratified neural retina from human ESCs. , 2012, Cell stem cell.

[122]  S. Nishikawa,et al.  Highly Sensitive In Vitro Methods for Detection of Residual Undifferentiated Cells in Retinal Pigment Epithelial Cells Derived from Human iPS Cells , 2012, PloS one.

[123]  E. L. West,et al.  Restoration of vision after transplantation of photoreceptors , 2012, Nature.

[124]  E. Percin,et al.  Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses. , 2012, Investigative ophthalmology & visual science.

[125]  K. Manova-Todorova,et al.  Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma , 2012, PloS one.

[126]  T. Salt,et al.  Human Müller Glia with Stem Cell Characteristics Differentiate into Retinal Ganglion Cell (RGC) Precursors In Vitro and Partially Restore RGC Function In Vivo Following Transplantation , 2012, Stem cells translational medicine.

[127]  S. Schwartz,et al.  Embryonic stem cell trials for macular degeneration: a preliminary report , 2012, The Lancet.

[128]  Timothy A. Blenkinsop,et al.  Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives. , 2012, Cell stem cell.

[129]  Masayo Takahashi,et al.  Induction of retinal pigment epithelial cells from monkey iPS cells. , 2011, Investigative ophthalmology & visual science.

[130]  K. Martin,et al.  Concise Review: Toward Stem Cell‐Based Therapies for Retinal Neurodegenerative Diseases , 2011, Stem cells.

[131]  R. Stewart,et al.  Optic Vesicle‐like Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment , 2011, Stem cells.

[132]  R. Kardon,et al.  Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. , 2011, Investigative ophthalmology & visual science.

[133]  Thomas Vierbuchen,et al.  Induction of human neuronal cells by defined transcription factors , 2011, Nature.

[134]  S. Lipton,et al.  Direct reprogramming of mouse fibroblasts to neural progenitors , 2011, Proceedings of the National Academy of Sciences.

[135]  E. L. West,et al.  Effective Transplantation of Photoreceptor Precursor Cells Selected via Cell Surface Antigen Expression , 2011, Stem cells.

[136]  T. Adachi,et al.  Self-organizing optic-cup morphogenesis in three-dimensional culture , 2011, Nature.

[137]  Robert F Mullins,et al.  Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration. , 2011, Investigative ophthalmology & visual science.

[138]  H. Uusitalo,et al.  Toward the defined and xeno-free differentiation of functional human pluripotent stem cell–derived retinal pigment epithelial cells , 2011, Molecular vision.

[139]  Fumitaka Osakada,et al.  Modeling Retinal Degeneration Using Patient-Specific Induced Pluripotent Stem Cells , 2011, PloS one.

[140]  Shinn-Zong Lin,et al.  Mesenchymal Stem Cells , 2011, Cell transplantation.

[141]  M. Mochizuki,et al.  Inhibition of B-cell activation by retinal pigment epithelium. , 2010, Investigative ophthalmology & visual science.

[142]  S. E. Barker,et al.  Long‐Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation , 2010, Stem cells.

[143]  A. Cselenyák,et al.  Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections , 2010, BMC Cell Biology.

[144]  G. Daley,et al.  Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice , 2010, PloS one.

[145]  N. Marina,et al.  Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. , 2010, Investigative ophthalmology & visual science.

[146]  W. Thoreson,et al.  Induced Pluripotent Stem Cells Generate Both Retinal Ganglion Cells and Photoreceptors: Therapeutic Implications in Degenerative Changes in Glaucoma and Age‐Related Macular Degeneration , 2010, Stem cells.

[147]  F. Djouad,et al.  Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications , 2010, Stem Cell Research & Therapy.

[148]  D. van der Kooy,et al.  A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. , 2010, Biomaterials.

[149]  D. Baas,et al.  The dynamic nature of Bruch's membrane , 2010, Progress in Retinal and Eye Research.

[150]  Thomas Vierbuchen,et al.  Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.

[151]  Pei-Rong Wang,et al.  Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells , 2010, PloS one.

[152]  M. Mandai,et al.  Use of Lectins to Enrich Mouse ES-Derived Retinal Progenitor Cells for the Purpose of Transplantation Therapy , 2010, Cell transplantation.

[153]  M. Mandai,et al.  Induced pluripotent stem cells for retinal degenerative diseases: a new perspective on the challenges , 2009, Journal of Genetics.

[154]  S. Kase,et al.  Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: Relevance to age-related macular degeneration , 2009, Aging.

[155]  Kathleen A. Marshall,et al.  Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial , 2009, The Lancet.

[156]  Gideon Rechavi,et al.  Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. , 2009, Cell stem cell.

[157]  D. Clegg,et al.  Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells , 2009, Stem cells.

[158]  Robert Lanza,et al.  EMBRYONIC STEM CELLS / INDUCED PLURIPOTENT STEM CELLS Long-Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration , 2009 .

[159]  Y. Sasai,et al.  In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction , 2009, Journal of Cell Science.

[160]  Shujie Xie,et al.  Nerve growth factor-mediated paracrine regulation of hepatic stellate cells by multipotent mesenchymal stromal cells. , 2009, Life sciences.

[161]  S. Yamanaka,et al.  Generation of retinal cells from mouse and human induced pluripotent stem cells , 2009, Neuroscience Letters.

[162]  S. Sugita,et al.  Role of ocular pigment epithelial cells in immune privilege , 2009, Archivum Immunologiae et Therapiae Experimentalis.

[163]  Y. Sasai,et al.  Stepwise differentiation of pluripotent stem cells into retinal cells , 2009, Nature Protocols.

[164]  Rajendran Sanalkumar,et al.  In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors. , 2009, Biochemical and biophysical research communications.

[165]  T. Reh,et al.  Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. , 2009, Cell stem cell.

[166]  H. Aburatani,et al.  Retinal Pigment Epithelium-Derived CTLA-2α Induces TGFβ-Producing T Regulatory Cells12 , 2008, The Journal of Immunology.

[167]  W. Hauswirth,et al.  Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. , 2008, Human gene therapy.

[168]  G. Parmigiani,et al.  Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. , 2008, The New England journal of medicine.

[169]  Y. Torrente,et al.  Mesenchymal Stem Cell Transplantation for Neurodegenerative Diseases , 2008, Cell transplantation.

[170]  H. Gerdes,et al.  Intercellular transfer mediated by tunneling nanotubes. , 2008, Current opinion in cell biology.

[171]  S. Sadda,et al.  Retinal transplants restore visual responses: trans‐synaptic tracing from visually responsive sites labels transplant neurons , 2008, The European journal of neuroscience.

[172]  Nagahisa Yoshimura,et al.  Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells , 2008, Nature Biotechnology.

[173]  Shulan Tian,et al.  Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells , 2007, Science.

[174]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[175]  B. Stanzel,et al.  Transplantation of the RPE in AMD , 2007, Progress in Retinal and Eye Research.

[176]  M. Araie,et al.  Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration. , 2007, Experimental eye research.

[177]  N. Gupta,et al.  Glaucoma as a neurodegenerative disease , 2007, Current opinion in ophthalmology.

[178]  K. Addicks,et al.  Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse , 2007, Graefe's Archive for Clinical and Experimental Ophthalmology.

[179]  M. Mochizuki,et al.  Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta. , 2006, Experimental eye research.

[180]  Dyonne T Hartong,et al.  Retinitis pigmentosa , 2009 .

[181]  T. Salt,et al.  Retinal repair by transplantation of photoreceptor precursors , 2006, Nature.

[182]  R. Lund,et al.  Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. , 2006, Cloning and stem cells.

[183]  J. Streilein,et al.  Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation. , 2006, Investigative ophthalmology & visual science.

[184]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[185]  Guodong Pan,et al.  Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion. , 2006, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[186]  Victoria A. Higman,et al.  TSG-6: a pluripotent inflammatory mediator? , 2006, Biochemical Society transactions.

[187]  R. Mullins,et al.  Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina. , 2006, Molecular vision.

[188]  Weng Tao,et al.  Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[189]  H. Quigley,et al.  The number of people with glaucoma worldwide in 2010 and 2020 , 2006, British Journal of Ophthalmology.

[190]  K. Mizuseki,et al.  Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[191]  Olaf Strauss,et al.  The retinal pigment epithelium in visual function. , 2005, Physiological reviews.

[192]  R. Lund,et al.  Grafting of ARPE-19 and Schwann cells to the subretinal space in RCS rats. , 2005, Investigative ophthalmology & visual science.

[193]  Megan Sykes,et al.  Organ transplantation—how much of the promise has been realized? , 2005, Nature Medicine.

[194]  C. Osmond,et al.  Association of HLA class I and class II polymorphisms with age-related macular degeneration. , 2005, Investigative ophthalmology & visual science.

[195]  J. Ott,et al.  Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.

[196]  J. Streilein,et al.  Thrombospondin plays a vital role in the immune privilege of the eye. 2005. , 2005, Ocular immunology and inflammation.

[197]  M. Al-Ghanim,et al.  Registered Blindness and Low Vision in Kuwait , 2005, Ophthalmic epidemiology.

[198]  R. Hilgers,et al.  Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: a prospective trial. , 2004, Investigative ophthalmology & visual science.

[199]  C. Cepko,et al.  Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10 , 2004, Development.

[200]  Jason Hipp,et al.  Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. , 2004, Cloning and stem cells.

[201]  J. Vilček,et al.  Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14. , 2004, Cytokine & growth factor reviews.

[202]  M. Burnett,et al.  Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms , 2004, Circulation.

[203]  Y. Sasai,et al.  In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. , 2004, Investigative ophthalmology & visual science.

[204]  R. Kuijpers,et al.  Autologous peripheral retinal pigment epithelium translocation in patients with subfoveal neovascular membranes , 2003, The British journal of ophthalmology.

[205]  P. Sieving,et al.  Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[206]  F. Ghosh,et al.  TRANSPLANTATION OF FULL-THICKNESS RETINA IN THE RHODOPSIN TRANSGENIC PIG , 2002, Retina.

[207]  Masaru Miyagi,et al.  Drusen proteome analysis: An approach to the etiology of age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[208]  Weng Tao,et al.  Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. , 2002, Investigative ophthalmology & visual science.

[209]  R. Aramant,et al.  Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. , 2002, Experimental eye research.

[210]  G. Sukhikh,et al.  Mesenchymal Stem Cells , 2002, Bulletin of Experimental Biology and Medicine.

[211]  R. Hilgers,et al.  Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age-related macular degeneration: a pilot study. , 2002, American journal of ophthalmology.

[212]  Kenji Mizuseki,et al.  Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[213]  Robert F. Mullins,et al.  An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration , 2001, Progress in Retinal and Eye Research.

[214]  K. Mizuseki,et al.  Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity , 2000, Neuron.

[215]  G. Travis,et al.  Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[216]  S. Meri,et al.  Complement activation after oxidative stress: role of the lectin complement pathway. , 2000, The American journal of pathology.

[217]  M. Luciani,et al.  The ABCA subclass of mammalian transporters. , 1999, Biochimica et biophysica acta.

[218]  D. Birch,et al.  Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice , 1999, Cell.

[219]  D. Hinton,et al.  Retinal Pigment Epithelial Cells Are Heterogeneous in Their Expression of MHC-II After Stimulation with Interferon-γ , 1999 .

[220]  M. Killingsworth,et al.  Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study , 1999, The British journal of ophthalmology.

[221]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[222]  J. Streilein,et al.  Analysis of immune deviation elicited by antigens injected into the subretinal space. , 1998, Investigative Ophthalmology and Visual Science.

[223]  D. H. Rapaport,et al.  Inductive competence, its significance in retinal cell fate determination and a role for Delta-Notch signaling. , 1998, Seminars in cell & developmental biology.

[224]  D. Bok,et al.  Transplantation of retinal pigment epithelial cells and immune response in the subretinal space. , 1998, Investigative ophthalmology & visual science.

[225]  J. Lupski,et al.  A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Starqardt macular dystrophy , 1997, Nature Genetics.

[226]  H. Quigley.  Number of people with glaucoma worldwide. , 1996, The British journal of ophthalmology.

[227]  D. Lefer,et al.  Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. , 1995, The American journal of pathology.

[228]  A. Hendrickson,et al.  Development of cone photoreceptors and their synapses in the human and monkey fovea , 2019, The Journal of comparative neurology.

[229]  M. Mandai,et al.  Evaluation of the Surgical Device and Procedure for Extracellular Matrix-Scaffold-Supported Human iPSC-Derived Retinal Pigment Epithelium Cell Sheet Transplantation. , 2017, Investigative ophthalmology & visual science.

[230]  Giovanni Staurenghi,et al.  Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. , 2017, The New England journal of medicine.

[231]  K. Suzuma,et al.  Induction of Functional 3D Ciliary Epithelium-Like Structure From Mouse Induced Pluripotent Stem Cells. , 2016, Investigative ophthalmology & visual science.

[232]  Robert J Zawadzki,et al.  Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: preliminary phase 1 clinical trial findings. , 2014, Investigative ophthalmology & visual science.

[233]  I. Barshack,et al.  Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy. , 2014, Experimental eye research.

[234]  Uma Lakshmipathy,et al.  Pluripotent Stem Cells , 2013, Methods in Molecular Biology.

[235]  Masayo Takahashi,et al.  Generation of retinal cells from pluripotent stem cells. , 2012, Progress in brain research.

[236]  A. Björklund,et al.  Functional neural transplantation III. Primary and stem cell therapies for brain repair, part I. Introduction. , 2012, Progress in brain research.

[237]  S. Lipton,et al.  Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. , 2011, Cell stem cell.

[238]  P.T.V.M. de Jong,et al.  Mechanisms of disease: Age-related macular degeneration , 2006 .

[239]  P. D. de Jong,et al.  Age-related macular degeneration. , 2006, The New England journal of medicine.

[240]  L. Priore,et al.  Reattachment to a substrate prevents apoptosis of human retinal pigment epithelium , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[241]  G. Jensen,et al.  Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults: the Copenhagen City Eye Study. , 2004, Ophthalmology.

[242]  F. Ghosh,et al.  Graft-host connections in long-term full-thickness embryonic rabbit retinal transplants. , 1999, Investigative ophthalmology & visual science.

[243]  L. da Cruz,et al.  Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay , 2009, Molecular vision.