Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells
暂无分享,去创建一个
Stephen L. Abrams | F. E. Bertrand | J. McCubrey | W. Chappell | L. Steelman | D. Ludwig | L. Steelman | J. G. Shelton | S. L. Abrams | Linda S. Steelman | E. R. White | Edmond R. White | Dale L. Ludwig
[1] Ryuji Kobayashi,et al. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. , 2005, Cancer research.
[2] D. Hicklin,et al. A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity* , 2005, Journal of Biological Chemistry.
[3] R. Vessella,et al. In vivo Effects of the Human Type I Insulin-Like Growth Factor Receptor Antibody A12 on Androgen-Dependent and Androgen-Independent Xenograft Human Prostate Tumors , 2005, Clinical Cancer Research.
[4] Stephen L. Abrams,et al. Effects of Endogenous Epidermal Growth Factor Receptor Signaling on DNA Synthesis and ERK Activation in a Cytokine-Dependent Hematopoietic Cell Line , 2005, Cell cycle.
[5] Stephen L. Abrams,et al. Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines , 2005, Cell cycle.
[6] L. Schwartz,et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] Mark W Tengowski,et al. Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871 , 2005, Clinical Cancer Research.
[8] R. Bataille,et al. CD221 (IGF-1R) is aberrantly expressed in multiple myeloma, in relation to disease severity. , 2005, Haematologica.
[9] C. Singer,et al. Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer , 2005, Journal of Cancer Research and Clinical Oncology.
[10] J. McCubrey,et al. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells , 2004, Oncogene.
[11] T. Libermann,et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. , 2004, Cancer cell.
[12] P. Bohlen,et al. Simultaneous Blockade of Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor Signaling Pathways in Cancer Cells with a Fully Human Recombinant Bispecific Antibody* , 2004, Journal of Biological Chemistry.
[13] F. Peruzzi,et al. The IGF‐1 receptor in cancer biology , 2003, International journal of cancer.
[14] Peter Bohlen,et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. , 2003, Cancer research.
[15] D. Roith. The Insulin-Like Growth Factor System , 2003, Experimental Diabesity Research.
[16] C. Roberts,et al. The insulin-like growth factor system and cancer. , 2003, Cancer letters.
[17] M. Rolfe,et al. Anticancer antibodies. , 2003, American journal of clinical pathology.
[18] R. Baserga,et al. IGF-I receptor signalling in transformation and differentiation , 2001, Molecular pathology : MP.
[19] M. Glennie,et al. Clinical trials of antibody therapy. , 2000, Immunology today.
[20] J. Blatt. IGF1 AND LEUKEMIA , 2000, Pediatric hematology and oncology.
[21] I. Shimon,et al. The insulin-like growth factor system in regulation of normal and malignant hematopoiesis. , 1995, Leukemia research.
[22] G. Freund,et al. Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines. , 1994, Cancer research.
[23] J. McCubrey,et al. Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism. , 1991, Blood.