Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer

Background and Aims:  Irinotecan (CPT‐11) is a chemotherapeutic drug for cancer that causes severe diarrhea by an uncertain mechanism. The aim of the present study was to investigate the time‐course of apoptosis and whole intestinal damage after irinotecan to further elucidate the mechanism behind the diarrhea.

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