Chemistry with [18F]Fluoride Ion

The success of molecular imaging with positron-emission tomography (PET) depends on the availability of selective molecular probes labeled with positron-emitters, such asfluorine-18 (t1/2 = 109.7 min). No-carrier-added (NCA) [18F]fluoride ion (18F–) is the primary reagent for the preparation of 18F-labeled tracers in high specific activity. In this microreview, we survey current and advancing radiochemical methods and technologies for the use of NCA [18F]fluoride ion in the preparation of 18F-labeled radiotracers for applications with PET. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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