Pulsatile vs. non-pulsatile flow during cardiopulmonary bypass. A comparison of early postoperative changes.

The aim of the study was to evaluate possible haemodynamic and metabolic effects of pulsatile flow in cardiopulmonary bypass. The subjects were 20 patients undergoing coronary artery bypass grafting. They had no complicating diseases. Ten consecutive patients with pulsatile perfusion were compared with ten consecutive patients with non-pulsatile perfusion. The haemodynamic parameters, chest X-rays, fluid balance and changes in circulating thrombocytes were unaffected by adding pulsatile flow to cardiopulmonary bypass. The arterial-venous oxygen content difference and intrapulmonary shunting were also unaffected. Whole-body oxygen consumption was higher in the pulsatile group immediately after bypass, but subsequently there were no differences. The haemoglobin and haematocrit values were higher in the non-pulsatile group two hours postoperatively, but did not differ in the rest of the observation period. The clinical course was similar in the two groups.

[1]  Y. Miyauchi,et al.  Quantitative and functional changes in platelets and their preservation during extracorporeal circulation. , 1982, The Journal of cardiovascular surgery.

[2]  WN Gardner,et al.  Quantitative analysis of effect of neodymium-YAG laser on transplanted mouse carcinomas. , 1982, Thorax.

[3]  K. Taylor,et al.  Comparative clinical study of pulsatile and non-pulsatile perfusion in 350 consecutive patients. , 1982, Thorax.

[4]  J. Copeland,et al.  Plasma propranolol before, during, and after cardiopulmonary bypass , 1981, Clinical pharmacology and therapeutics.

[5]  M. Henderson,et al.  Hypertension after coronary operation. Can it be prevented by pulsatile perfusion? , 1981, The Journal of thoracic and cardiovascular surgery.

[6]  M. Blaufox,et al.  Pulsatile Cardiopulmonary Bypass: Failure to Influence Hemodynamics or Hormones , 1980, Circulation.

[7]  R. Ross.  The next 30 years--will the progress continue? , 1980, Circulation.

[8]  K. Taylor,et al.  Peripheral vascular resistance and angiotensin II levels during pulsatile and no-pulsatile cardiopulmonary bypass. , 1979, Thorax.

[9]  D. Murphy,et al.  Does pulsatile flow influence the incidence of postoperative hypertension? , 1979, The Annals of thoracic surgery.

[10]  K. Taylor,et al.  Comparative studies of pulsatile and nonpulsatile flow during cardiopulmonary bypass. I. Pulsatile system employed and its hematologic effects. , 1978, The Journal of thoracic and cardiovascular surgery.

[11]  R. Tarazi,et al.  Acute hypertension immediately after coronary artery surgery , 1976 .

[12]  J. Straker,et al.  Hemodynamic, metabolic, and hematologic effects of pulsatile cardiopulmonary bypass. , 1974, The Journal of thoracic and cardiovascular surgery.

[13]  R. Tarazi,et al.  Systemic hypertension following myocardial revascularization. , 1973, American heart journal.

[14]  R. S. Weiner,et al.  A Study of Platelet Counts During Cardiopulmonary Bypass , 1972, Transfusion.

[15]  R B Shepard,et al.  Relation of pulsatile flow to oxygen consumption and other variables during cardiopulmonary bypass. , 1969, The Journal of thoracic and cardiovascular surgery.

[16]  W. Sealy,et al.  Pathogenesis of pulmonary damage during extracorporeal perfusion. , 1966, Archives of surgery.

[17]  John,et al.  Blood gas calculator. , 1966, Journal of applied physiology.

[18]  V. Gott,et al.  Angiotensin II levels during cardiopulmonary bypass: a comparison of pulsatile and nonpulsatile flow. , 1979, Surgical forum.