CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

[1]  D. Lowy,et al.  The COVID-19 Serology Studies Workshop: Recommendations and Challenges , 2020, Immunity.

[2]  E. Wherry,et al.  Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. , 2020, Immunity.

[3]  T. Schumacher,et al.  CD8+ T cell states in human cancer: insights from single-cell analysis , 2020, Nature Reviews Cancer.

[4]  F. Jamali,et al.  Single dose pharmacokinetics and bioavailability of glucosamine in the rat. , 2002, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[5]  A. Regev,et al.  Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma , 2019, Nature Medicine.

[6]  G. Freeman,et al.  Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection. , 2019, Immunity.

[7]  David M. Schauder,et al.  CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer. , 2019, Immunity.

[8]  S. Berger,et al.  TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision. , 2019, Immunity.

[9]  M. Delorenzi,et al.  TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection , 2019, Nature.

[10]  Yong Liu,et al.  TOX is a critical regulator of tumour-specific T cell differentiation , 2019, Nature.

[11]  S. Berger,et al.  TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion , 2019, Nature.

[12]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[13]  P. Hogan,et al.  TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion , 2019, Proceedings of the National Academy of Sciences.

[14]  Elisabeth F. Heuston,et al.  Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8+ T cell Persistence in Chronic Infection , 2019, Nature Immunology.

[15]  J. Zuber,et al.  The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells , 2019, Genes & development.

[16]  Samantha Riesenfeld,et al.  EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data , 2019, Genome Biology.

[17]  F. Hodi,et al.  Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade , 2019, Nature Immunology.

[18]  S. Kulp,et al.  SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion , 2019, Cancer Immunology Research.

[19]  Paul J. Hoover,et al.  Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma , 2018, Cell.

[20]  G. Almouzni,et al.  Chromatin plasticity: A versatile landscape that underlies cell fate and identity , 2018, Science.

[21]  Ambrose J. Carr,et al.  Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment , 2018, Cell.

[22]  Jonathan Scolnick,et al.  Faculty Opinions recommendation of Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[23]  Boxi Kang,et al.  Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing , 2018, Nature Medicine.

[24]  C. Klein,et al.  A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade , 2018, Nature Network Boston.

[25]  Aviv Regev,et al.  Induction and transcriptional regulation of the co-inhibitory gene module in T cells , 2018, Nature.

[26]  E. Wherry,et al.  Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155. , 2018, Cell reports.

[27]  Aaron T. L. Lun,et al.  Distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data , 2018 .

[28]  Luke Zappia,et al.  Clustering trees: a visualization for evaluating clusterings at multiple resolutions , 2018, bioRxiv.

[29]  F. Charlotte,et al.  Simple, Reproducible, and Efficient Clinical Grading System for Murine Models of Acute Graft-versus-Host Disease , 2018, Front. Immunol..

[30]  Sebastian Amigorena,et al.  The epigenetic control of stemness in CD8+ T cell fate commitment , 2018, Science.

[31]  Koichi Araki,et al.  EFFECTOR CD8 T CELLS DEDIFFERENTIATE INTO LONG-LIVED MEMORY CELLS , 2017, Nature.

[32]  C. Rice,et al.  Intrinsic Immunity Shapes Viral Resistance of Stem Cells , 2017, Cell.

[33]  T. Chan,et al.  Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab , 2017, Cell.

[34]  Paul G. Thomas,et al.  De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation , 2017, Cell.

[35]  Christina S. Leslie,et al.  Chromatin states define tumor-specific T cell dysfunction and reprogramming , 2017, Nature.

[36]  Steven H. Kleinstein,et al.  Polycomb Repressive Complex 2‐Mediated Chromatin Repression Guides Effector CD8+ T Cell Terminal Differentiation and Loss of Multipotency , 2017, Immunity.

[37]  Todd M. Allen,et al.  The epigenetic landscape of T cell exhaustion , 2016, Science.

[38]  S. Berger,et al.  Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade , 2016, Science.

[39]  B. Salomon,et al.  Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells. , 2016, Blood.

[40]  Aviv Regev,et al.  A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells , 2016, Cell.

[41]  Sandra P. Calderon-Copete,et al.  T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. , 2016, Immunity.

[42]  J. Sosman,et al.  Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma , 2016, Cell.

[43]  L. Overman,et al.  H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus , 2016, The Journal of Neuroscience.

[44]  E. Wherry,et al.  Molecular and cellular insights into T cell exhaustion , 2015, Nature Reviews Immunology.

[45]  E. Wherry,et al.  Overcoming T cell exhaustion in infection and cancer. , 2015, Trends in immunology.

[46]  H. Lähdesmäki,et al.  The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells. , 2015, Immunity.

[47]  O. Kovalchuk,et al.  A role for SUV39H1-mediated H3K9 trimethylation in the control of genome stability and senescence in WI38 human diploid lung fibroblasts , 2014, Aging.

[48]  Howard Y. Chang,et al.  Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position , 2013, Nature Methods.

[49]  Burton E. Barnett,et al.  Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection , 2012, Science.

[50]  H. A. Schreiber,et al.  An epigenetic silencing pathway controlling T helper 2 cell lineage commitment , 2012, Nature.

[51]  S. Rosenberg,et al.  Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. , 2009, Blood.

[52]  R. Yeh,et al.  Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells , 2008, Oncogene.

[53]  Karl Mechtler,et al.  Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability , 2001, Cell.

[54]  P. Chambon,et al.  Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. , 2001, Molecular cell.

[55]  C. Ponting,et al.  Regulation of chromatin structure by site-specific histone H3 methyltransferases , 2000, Nature.

[56]  Julian Tang Rejuvenation , 1928, Nature.