The mutator mut7-1 of Saccharomyces cerevisiae.

The mut7-1 mutant of Saccharomyces cerevisiae is a cell-division-cycle mutant, exhibiting temperature-sensitive lethality and enhancement of mutator activity with increases in temperature. The base-sequence alterations in mutants arising in a mut7-1 background differed from the control by there being a higher transversion/transition ratio and by the much increased production of multi-base deletions. The deletions were, in every instance, associated with repeated oligonucleotide sequences (3-8 bases in length), where one of the two sequences was removed during the deletion process. The mutant mut7-1 failed to complement with cdc2, the temperature-sensitive mutant of the locus which encodes DNA polymerase III (delta).

[1]  R. V. von Borstel,et al.  Different Rates of Spontaneous Mutation during Mitosis and Meiosis in Yeast. , 1962, Genetics.

[2]  L. Johnston,et al.  Pathway correcting DNA replication errors in Saccharomyces cerevisiae. , 1993, The EMBO journal.

[3]  R. Borstel.  Chapter 1 Measuring Spontaneous Mutation Rates in Yeast , 1978 .

[4]  G. Mohn.  [Correlation between decreased reparative capability of UV lesions and higher spontaneous mutability in a mutator strain of E. coli K-12]. , 1968, Molecular & general genetics : MGG.

[5]  A. Nasim,et al.  Cross sensitivity of mutator strains to physical and chemical mutagens. , 1979, Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie.

[6]  D. Botstein,et al.  Structure and function of the yeast URA3 gene: expression in Escherichia coli. , 1984, Gene.

[7]  P. Hanawalt,et al.  REPAIR REPLICATION OF DNA IN BACTERIA: IRRELEVANCE OF CHEMICAL NATURE OF BASE DEFECT. , 1965, Biochemical and biophysical research communications.

[8]  G. Faye,et al.  Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III. , 1989, The EMBO journal.

[9]  L. Johnston,et al.  DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae. , 1992, The EMBO journal.

[10]  L. Hartwell,et al.  Genetic control of the cell division cycle in yeast. , 1974, Science.

[11]  H. Maki,et al.  Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coli. , 1991, Journal of molecular biology.

[12]  H. Muller.  The Measurement of Gene Mutation Rate in Drosophila, Its High Variability, and Its Dependence upon Temperature. , 1928, Genetics.

[13]  R. Borstel,et al.  Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA , 1976, Nature.

[14]  K. Jyssum.  Mutator Factor in Neisseria meningitidis Associated with Increased Sensitivity to Ultraviolet Light and Defective Transformation , 1968, Journal of bacteriology.

[15]  J. Speyer,et al.  On the role of DNA polymerase in base selection. , 1966, Cold Spring Harbor symposia on quantitative biology.

[16]  C. Steinberg,et al.  Inheritance of spontaneous mutability in yeast. , 1971, Genetics.

[17]  D. Gordenin,et al.  Transposon Tn5 excision in yeast: influence of DNA polymerases alpha, delta, and epsilon and repair genes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[18]  S. Kondo.  A theoretical study on spontaneous mutation rate. , 1972, Mutation research.

[19]  H. Böhme.  Genetic instability of an ultraviolet-sensitive mutant of Proteus mirabilis. , 1967, Biochemical and biophysical research communications.

[20]  L. Hartwell,et al.  Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. , 1973, Genetics.

[21]  D. Williamson,et al.  The use of fluorescent DNA-binding agent for detecting and separating yeast mitochondrial DNA. , 1975, Methods in cell biology.

[22]  R. V. von Borstel,et al.  Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants. , 1992, Journal of molecular biology.

[23]  J. Overbaugh,et al.  The origin of mutants , 1988, Nature.

[24]  R. Borstel,et al.  The origin of spontaneous mutation in Saccharomyces cerevisiae. , 1980, Genetics.