Dipolar source modeling of the P300 event‐related potential after somatosensory stimulation

The cerebral generators of the P300 potential evoked by somatosensory stimuli were investigated. Event‐related potentials elicited by an oddball paradigm were recorded in 15 healthy subjects by 19 scalp electrodes. Nontarget and target electric stimuli were delivered on the anterior surface of the left elbow and of the wrist, respectively. Target traces showed an N140 potential followed by a widely distributed P300 response. Dipolar source modeling of target traces resulted in a six‐dipole model. In the earlier latency range (up to 200 ms), one dipole in the contralateral perirolandic region and two dipoles in the parasylvian cortex of both hemispheres were activated. Two dipolar sources located bilaterally in the medial temporal region (MTR) showed their maximal activity at the P300 latency. Finally, a dipole in the contralateral frontal lobe was activated both at the latency of the N140 response and after 200 ms. It was found that two symmetrical MTR sources and a frontal dipole contributed to P300 generation. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1677–1686, 2001

[1]  M Honda,et al.  The role of the hippocampus in auditory processing studied by event-related electric potentials and magnetic fields in epilepsy patients before and after temporal lobectomy. , 1999, Brain : a journal of neurology.

[2]  R. Johnson.  Developmental evidence for modality-dependent P300 generators: a normative study. , 1989, Psychophysiology.

[3]  A Pfefferbaum,et al.  Clinical utility of long latency 'cognitive' event-related potentials (P3): the cons. , 1990, Electroencephalography and clinical neurophysiology.

[4]  F. Perrin,et al.  Mapping of scalp potentials by surface spline interpolation. , 1987, Electroencephalography and clinical neurophysiology.

[5]  1 Neurophysiological Considerations in Event-Related Potential Research , 1983 .

[6]  E. Halgren,et al.  The intracranial topography of the P3 event-related potential elicited during auditory oddball. , 1990, Electroencephalography and clinical neurophysiology.

[7]  M. Velasco,et al.  Subcortical correlates of the P300 potential complex in man to auditory stimuli. , 1986, Electroencephalography and clinical neurophysiology.

[8]  M. Scherg.  Fundamentals if dipole source potential analysis , 1990 .

[9]  G. V. Simpson,et al.  Localization and temporal activity functions of brain sources generating the human visual ERP , 1990 .

[10]  Domenico Restuccia,et al.  Dipolar sources of the early scalp somatosensory evoked potentials to upper limb stimulation Effect of increasing stimulus rates , 1998, Experimental Brain Research.

[11]  J Debecker,et al.  Wave form and neural mechanism of the decision P350 elicited without pre-stimulus CNV or readiness potential in random sequences of near-threshold auditory clicks and finger stimuli. , 1979, Electroencephalography and clinical neurophysiology.

[12]  Eric Halgren,et al.  Generators of the human scalp P3(s) , 1986 .

[13]  Christoph Braun,et al.  Auditory and somatosensory event-related potentials: I. Effects of attention , 1991 .

[14]  P. Goldman-Rakic,et al.  Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. , 1997, Journal of neurophysiology.

[15]  C. C. Wood,et al.  Task-dependent field potentials in human hippocampal formation , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[16]  R. Johnson,et al.  On the neural generators of the P300 component of the event-related potential. , 2007, Psychophysiology.

[17]  M. Onofrj,et al.  P3 recordings in patients with bilateral temporal lobe lesions , 1992, Neurology.

[18]  R Kakigi,et al.  Source modelling of the EEG and MEG oddball response in a subject with a large P300. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[19]  Roberto D. Pascual-Marqui,et al.  Electrical Sources of P300 Event-Related Brain Potentials Revealed by Low Resolution Electromagnetic Tomography , 1997, Neuropsychobiology.

[20]  M. Onofrj,et al.  Mapping of event-related potentials to auditory and visual odd-ball paradigms in controls. , 1991, European neurology.

[21]  H. Shibasaki,et al.  Human auditory and somatosensory event-related potentials: effects of response condition and age. , 1987, Electroencephalography and clinical neurophysiology.

[22]  I. Kiss,et al.  A parieto-occipital generator for P300: evidence from human intracranial recordings. , 1989, The International journal of neuroscience.

[23]  R. Knight,et al.  Contributions of temporal-parietal junction to the human auditory P3 , 1989, Brain Research.

[24]  A. Friederici,et al.  The functional neuroanatomy of novelty processing: integrating ERP and fMRI results. , 1999, Cerebral cortex.

[25]  F. Mauguière,et al.  Target side and scalp topography of the somatosensory P300. , 1993, Electroencephalography and clinical neurophysiology.

[26]  R. Knight.  Contribution of human hippocampal region to novelty detection , 1996, Nature.

[27]  D. V. von Cramon,et al.  Combining electrophysiological and hemodynamic measures of the auditory oddball. , 1999, Psychophysiology.

[28]  G. Romani,et al.  Auditory evoked magnetic fields and electric potentials , 1990 .

[29]  R. Johnson,et al.  On the neural generators of the P300: evidence from temporal lobectomy patients. , 1995, Electroencephalography and clinical neurophysiology. Supplement.

[30]  R. Verleger,et al.  Reduction of P3b in patients with temporo-parietal lesions. , 1994, Brain research. Cognitive brain research.

[31]  C. Yingling,et al.  A subcortical correlate of P300 in man. , 1984, Electroencephalography and clinical neurophysiology.

[32]  A. Papanicolaou,et al.  Electric source localization of the auditory P300 agrees with magnetic source localization. , 1995, Electroencephalography and clinical neurophysiology.

[33]  C C Wood,et al.  Intracranial recordings of endogenous ERPs in humans. , 1985, Electroencephalography and clinical neurophysiology. Supplement.

[34]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. I. Superior temporal plane and parietal lobe. , 1995, Electroencephalography and clinical neurophysiology.

[35]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. II. Medial, lateral and posterior temporal lobe. , 1995, Electroencephalography and clinical neurophysiology.

[36]  A. Fallgatter,et al.  Three-dimensional tomography of event-related potentials during response inhibition: evidence for phasic frontal lobe activation. , 1998, Electroencephalography and clinical neurophysiology.

[37]  T W Picton,et al.  Event-related potentials recorded from the scalp and nasopharynx. II. N2, P3 and slow wave. , 1984, Electroencephalography and clinical neurophysiology.

[38]  Klaus P. Ebmeier,et al.  Cognitive brain potentials and regional cerebral blood flow equivalents during two- and three-sound auditory "oddball tasks". , 1995, Electroencephalography and clinical neurophysiology.

[39]  J. Ford,et al.  The relationship between P300 amplitude and regional gray matter volumes depends upon the attentional system engaged. , 1994, Electroencephalography and clinical neurophysiology.

[40]  R. Benson,et al.  Responses to rare visual target and distractor stimuli using event-related fMRI. , 2000, Journal of neurophysiology.

[41]  A Z Snyder,et al.  Dipole source localization in the study of EP generators: a critique. , 1991, Electroencephalography and clinical neurophysiology.

[42]  C. C. Wood,et al.  The relationship between human long-latency somatosensory evoked potentials recorded from the cortical surface and from the scalp. , 1992, Electroencephalography and clinical neurophysiology.

[43]  Massimiliano Valeriani,et al.  Characterizing somatosensory evoked potential sources with dipole models: Advantages and limitations , 2001, Muscle & nerve.

[44]  J. Ford,et al.  Combined event‐related fMRI and EEG evidence for temporal—parietal cortex activation during target detection , 1997, Neuroreport.

[45]  D S Goodin,et al.  Clinical utility of long latency 'cognitive' event-related potentials (P3): the pros. , 1990, Electroencephalography and clinical neurophysiology.

[46]  V. Jousmäki,et al.  Activation of a distributed somatosensory cortical network in the human brain. A dipole modelling study of magnetic fields evoked by median nerve stimulation. Part I: Location and activation timing of SEF sources. , 1997, Electroencephalography and clinical neurophysiology.

[47]  Ulrich Hegerl,et al.  Dipole source analysis of P300 component of the auditory evoked potential: a methodological advance? , 1997, Psychiatry Research: Neuroimaging.

[48]  S. Yamaguchi,et al.  Anterior and posterior association cortex contributions to the somatosensory P300 , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[49]  R. Goebel,et al.  The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks. , 1999, Cerebral cortex.

[50]  S Micheloyannis,et al.  Generators for human P300 elicited by somatosensory stimuli using multiple dipole source analysis , 1996, Neuroscience.

[51]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex. , 1995, Electroencephalography and clinical neurophysiology.

[52]  L. Arendt-Nielsen,et al.  Dipolar source modeling of somatosensory evoked potentials to painful and nonpainful median nerve stimulation , 2000, Muscle & nerve.

[53]  R. Kakigi.  Somatosensory evoked magnetic fields following median nerve stimulation , 1994, Neuroscience Research.

[54]  M Hämäläinen,et al.  Somatosensory evoked cerebral magnetic fields from SI and SII in man. , 1984, Electroencephalography and clinical neurophysiology.

[55]  E. Halgren,et al.  Human medial temporal lobe potentials evoked in memory and language tasks. , 1986, Electroencephalography and clinical neurophysiology.