Retinoic acid signalling induces the differentiation of mouse fetal liver‐derived hepatic progenitor cells

Background: Hepatic progenitor cells (HPCs) can be isolated from fetal liver and extrahepatic tissues. Retinoic acid (RA) signalling plays an important role in development, although the role of RA signalling in liver‐specific progenitors is poorly understood.

[1]  T. He,et al.  BMP‐9‐induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/β‐catenin signalling , 2009, Journal of cellular and molecular medicine.

[2]  T. He,et al.  A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. , 2009, Stem cells and development.

[3]  T. He,et al.  Hey1 Basic Helix-Loop-Helix Protein Plays an Important Role in Mediating BMP9-induced Osteogenic Differentiation of Mesenchymal Progenitor Cells* , 2009, Journal of Biological Chemistry.

[4]  M. Grompe,et al.  Generation and Regeneration of Cells of the Liver and Pancreas , 2008, Science.

[5]  A. Montag,et al.  Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects , 2008, Laboratory Investigation.

[6]  F. Kikuchi,et al.  Expression of stem cell factor (SCF), a KIT ligand, in gastrointestinal stromal tumors (GISTs): a potential marker for tumor proliferation. , 2008, Pathology, research and practice.

[7]  H. Yoon,et al.  Hepatic differentiation of cord blood‐derived multipotent progenitor cells (MPCs) in vitro , 2008, Cell biology international.

[8]  G. Duester.  Retinoic Acid Synthesis and Signaling during Early Organogenesis , 2008, Cell.

[9]  P. Dollé,et al.  Retinoic acid in development: towards an integrated view , 2008, Nature Reviews Genetics.

[10]  Shiyong Chen,et al.  Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway. , 2008, Biochemical pharmacology.

[11]  K. Zaret.  Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation , 2008, Nature Reviews Genetics.

[12]  M. Oertel,et al.  Stem cells, cell transplantation and liver repopulation. , 2008, Biochimica et biophysica acta.

[13]  N. Hastie,et al.  Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. , 2007, Developmental biology.

[14]  C. Choong,et al.  Application of liver stem cells for cell therapy. , 2007, Seminars in cell & developmental biology.

[15]  D. Soprano,et al.  Retinoids in biological control and cancer , 2007, Journal of cellular biochemistry.

[16]  I. Hisatome,et al.  A role of Wnt/β-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells , 2007 .

[17]  M. Manns,et al.  Stem cells in liver regeneration and therapy , 2007, Cell and Tissue Research.

[18]  B. Christ,et al.  Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo. , 2007, Experimental cell research.

[19]  J. Berger,et al.  Retinaldehyde represses adipogenesis and diet-induced obesity , 2007, Nature Medicine.

[20]  S. Monga,et al.  WNT/β‐catenin signaling in liver health and disease , 2007 .

[21]  M. Karamouzis,et al.  The Molecular Basis of Retinoids’ Use in Breast Cancer Chemoprevention , 2007, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[22]  C. Guillemette,et al.  Regulation of the UGT1A1 bilirubin‐conjugating pathway: Role of a new splicing event at the UGT1A locus , 2007, Hepatology.

[23]  T. He,et al.  Osteosarcoma and Osteoblastic Differentiation: A New Perspective on Oncogenesis , 2007, Clinical orthopaedics and related research.

[24]  L. Libbrecht.  Hepatic progenitor cells in human liver tumor development. , 2006, World journal of gastroenterology.

[25]  D. Gerber,et al.  Hepatic Stem Cells: In Search of , 2006, Stem cells.

[26]  E. Schmelzer,et al.  The Phenotypes of Pluripotent Human Hepatic Progenitors , 2006, Stem cells.

[27]  U Kneser,et al.  Fetal and adult liver stem cells for liver regeneration and tissue engineering , 2006, Journal of cellular and molecular medicine.

[28]  T. Roskams.  Liver stem cells and their implication in hepatocellular and cholangiocarcinoma , 2006, Oncogene.

[29]  A. Montag,et al.  CCN1/Cyr61 Is Regulated by the Canonical Wnt Signal and Plays an Important Role in Wnt3A-Induced Osteoblast Differentiation of Mesenchymal Stem Cells , 2006, Molecular and Cellular Biology.

[30]  P. Chambon,et al.  Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. , 2006, Annual review of pharmacology and toxicology.

[31]  A. Montag,et al.  Connective Tissue Growth Factor (CTGF) Is Regulated by Wnt and Bone Morphogenetic Proteins Signaling in Osteoblast Differentiation of Mesenchymal Stem Cells* , 2004, Journal of Biological Chemistry.

[32]  G. M. Ledda-Columbano,et al.  Induction of hepatocyte proliferation by retinoic acid. , 2004, Carcinogenesis.

[33]  J. Szatkowski,et al.  Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery , 2004, Gene Therapy.

[34]  P. Shen.  Molecular mechanisms of chemoprevention and therapy of cancer by retinoids. , 2004, Frontiers in bioscience : a journal and virtual library.

[35]  Thomas M. Schmitt,et al.  Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions , 2004, The Journal of experimental medicine.

[36]  Wei Jiang,et al.  Inhibitor of DNA Binding/Differentiation Helix-Loop-Helix Proteins Mediate Bone Morphogenetic Protein-induced Osteoblast Differentiation of Mesenchymal Stem Cells* , 2004, Journal of Biological Chemistry.

[37]  J. A. Guadix,et al.  Contribution of mesothelium‐derived cells to liver sinusoids in avian embryos , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[38]  Hongwei Cheng,et al.  Transcriptional characterization of bone morphogenetic proteins (BMPs)‐mediated osteogenic signaling , 2003, Journal of cellular biochemistry.

[39]  E. Dmitrovsky,et al.  Retinoids in cancer therapy and chemoprevention: promise meets resistance , 2003, Oncogene.

[40]  V. Vivat-Hannah,et al.  Selective retinoids and rexinoids in cancer therapy and chemoprevention. , 2002, Drug discovery today.

[41]  M. Weiss,et al.  Inducible differentiation and morphogenesis of bipotential liver cell lines from wild‐type mouse embryos , 2002, Hepatology.

[42]  K. Zaret,et al.  Regulatory phases of early liver development: paradigms of organogenesis , 2002, Nature Reviews Genetics.

[43]  A. Montag,et al.  Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[44]  R. Haselbeck,et al.  Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. , 2002, Development.

[45]  H. Gronemeyer,et al.  Co-regulator recruitment and the mechanism of retinoic acid receptor synergy , 2002, Nature.

[46]  R. Evans,et al.  Nuclear receptors and lipid physiology: opening the X-files. , 2001, Science.

[47]  I. Talianidis,et al.  Regulatory Mechanisms Controlling Human Hepatocyte Nuclear Factor 4α Gene Expression , 2001, Molecular and Cellular Biology.

[48]  S. Sell,et al.  Heterogeneity and plasticity of hepatocyte lineage cells , 2001, Hepatology.

[49]  A. Rashid,et al.  Expansion of Hepatic and Hematopoietic Stem Cells Utilizing Mouse Embryonic Liver Explants , 2001, Cell transplantation.

[50]  B. Park,et al.  Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer , 2001, Current opinion in oncology.

[51]  A. Wolffe,et al.  Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription. , 1999, Journal of molecular endocrinology.

[52]  A. Jacob,et al.  The HNF-3α Transcription Factor Is a Primary Target for Retinoic Acid Action , 1999 .

[53]  P. Leboulch,et al.  Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[54]  R. Lotan.  Retinoids in cancer chemoprevention , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[55]  R. Lotan.  Retinoids and apoptosis: implications for cancer chemoprevention and therapy. , 1995, Journal of the National Cancer Institute.

[56]  C. Tyson,et al.  Regulation of differentiated phenotype of rat hepatic lipocytes by retinoids in primary culture. , 1995, Experimental cell research.

[57]  R. Costa,et al.  Retinoic acid-mediated activation of HNF-3α during EC stem cell differentiation , 1994 .

[58]  R. Evans,et al.  RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. , 1994, Genes & development.

[59]  S. Thorgeirsson,et al.  Hepatic regeneration in vitamin A-deficient rats: changes in the expression of transforming growth factor alpha/epidermal growth factor receptor and retinoic acid receptors alpha and beta. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[60]  M. Fagioli,et al.  The molecular genetics of acute promyelocytic leukemia. , 1993, Blood reviews.

[61]  I. Hisatome,et al.  A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[62]  S. Monga,et al.  WNT/beta-catenin signaling in liver health and disease. , 2007, Hepatology.

[63]  L. Mishra,et al.  Hepatocellular stem cells. , 2007, Cancer biomarkers : section A of Disease markers.

[64]  A. Montag,et al.  An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis , 2005, Clinical & Experimental Metastasis.

[65]  Franghiz Ali-Zadeh,et al.  In search of , 2005 .

[66]  Jean S. Campbell,et al.  The role of hepatocytes and oval cells in liver regeneration and repopulation , 2003, Mechanisms of Development.

[67]  A. Verma.  Retinoids in chemoprevention of cancer. , 2003, Journal of biological regulators and homeostatic agents.

[68]  R. Lotan,et al.  Retinoids and their receptors in cancer development and chemoprevention. , 2002, Critical reviews in oncology/hematology.

[69]  A. Jacob,et al.  The HNF-3alpha transcription factor is a primary target for retinoic acid action. , 1999, Experimental cell research.

[70]  M. Collins,et al.  Teratology of retinoids. , 1999, Annual review of pharmacology and toxicology.

[71]  D. Soprano,et al.  Retinoids as teratogens. , 1995, Annual review of nutrition.

[72]  R. Costa,et al.  Retinoic acid-mediated activation of HNF-3 alpha during EC stem cell differentiation. , 1994, Nucleic acids research.