Methods for the Production of Radionuclides for Medicine

Nuclear reactions involve the interaction of particles or photons with the nuclei of target atoms, resulting in the production of radioactive atoms that can be used in medicine for diagnostic or therapeutic purposes. The guiding principles and methods of radionuclide production are explored in this chapter, with a focus on reactor- and accelerator-based production. With few exceptions, nuclear reactors are used to produce neutron-rich nuclides that are mainly of interest for therapeutic radiopharmaceuticals, while cyclotrons are used to create proton-rich nuclides, which are of interest for diagnostic purposes. Additionally, generator systems and photonuclear production are briefly discussed. Included in this chapter are the practical considerations made when designing targets for radionuclide production, as well as simple tools used for predictive modeling of target behavior. The expansive combination of target materials and production methods has led to a wide range of possibilities for the development of new and exotic radionuclides—creating the framework for a well-equipped toolbox of radiopharmaceuticals.

[1]  A. Ereditato,et al.  Measurement of 43Sc and 44Sc production cross-section with an 18MeV medical PET cyclotron. , 2017, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[2]  J. F. Ziegler,et al.  Stopping and Range of Ions in Matter SRIM-2003 , 2003 .

[3]  R. Lecomte,et al.  Clinical Trial with Sodium 99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function , 2017, The Journal of Nuclear Medicine.

[4]  H. Maecke,et al.  68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals. , 2008, Contrast media & molecular imaging.

[5]  Bernadette V. Marquez,et al.  Cyclotron Production of High–Specific Activity 55Co and In Vivo Evaluation of the Stability of 55Co Metal-Chelate-Peptide Complexes , 2015, Molecular imaging.

[6]  J. C. Clark,et al.  Direct production of Ga-68 from proton bombardment of concentrated aqueous solutions of [Zn-68] Zinc Chloride , 2011 .

[7]  S. Freedman,et al.  Exchange of 11CO2 in arterial blood with body CO2 pools. , 1968, Respiration physiology.

[8]  T. Ruth,et al.  The Medical Isotope Crisis: How We Got Here and Where We Are Going , 2014, The Journal of Nuclear Medicine Technology.

[9]  F. Harmon,et al.  Sc-47 production from titanium targets using electron linacs. , 2015, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[10]  C. P. Baker,et al.  How the barn was born , 1972 .

[11]  H. Coenen,et al.  Production of the therapeutic radionuclides 193mPt and 195mPt with high specific activity via alpha-particle-induced reactions on 192Os. , 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[12]  N. M. Larson,et al.  ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data , 2011 .

[13]  V. Starovoitova,et al.  Target optimization for the photonuclear production of radioisotopes. , 2015, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[14]  A. Celler,et al.  Production of Y-86 and other radiometals for research purposes using a solution target system. , 2015, Nuclear medicine and biology.

[15]  S. Srivastava,et al.  Production of 82Sr by proton irradiation of RbCl , 1987 .

[16]  A. Celler,et al.  Molybdenum target specifications for cyclotron production of 99mTc based on patient dose estimates , 2016, Physics in medicine and biology.

[17]  J. Nye,et al.  A new binary compound for the production of 124I via the 124Te(p,n)124I reaction. , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[18]  R. Nickles,et al.  An 18O2 target for the production of [18F]F2 , 1984 .

[19]  S. Humphries,et al.  Principles of Charged Particle Acceleration , 1986 .

[20]  Aditya Bansal,et al.  Improved production and processing of ⁸⁹Zr using a solution target. , 2016, Nuclear medicine and biology.

[21]  T. Aweda,et al.  Production of Zr-89 using sputtered yttrium coin targets 89Zr using sputtered yttrium coin targets. , 2017, Nuclear medicine and biology.

[22]  M. Stokely,et al.  Thermal performance of batch boiling water targets for 18F production. , 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[23]  J. Nye,et al.  A grid-mounted niobium body target for the production of reactive [18F]fluoride. , 2006, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[24]  S. Jurisson,et al.  Proton irradiation parameters and chemical separation procedure for the bulk production of high-specific-activity 186gRe using WO3 targets , 2013 .

[25]  M J Welch,et al.  Efficient production of high specific activity 64Cu using a biomedical cyclotron. , 1997, Nuclear medicine and biology.