Muscle forces or gravity--what predominates mechanical loading on bone? Introduction.

This article describes the background, rationale, significance, and objective of the recent American College of Sports Medicine symposium entitled "Muscle Forces or Gravity-What Predominates Mechanical Loading on Bone?" (55th Annual Meeting, Indianapolis, IN, May 28, 2008) and introduces a series of papers representing the positions taken by three of the speakers at that symposium. Our goal was to reinvigorate discussion on a topic that will inform many, provoke some, and, most importantly, stimulate ideas that will encourage progress in the field of exercise prescription for bone.

[1]  J. Eng,et al.  A 19-week exercise program for people with chronic stroke enhances bone geometry at the tibia: a peripheral quantitative computed tomography study , 2006, Osteoporosis International.

[2]  A Heinonen,et al.  Effects of unilateral strength training and detraining on bone mineral mass and estimated mechanical characteristics of the upper limb bones in young women , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  A Heinonen,et al.  Adaptation of bone to altered loading environment: a biomechanical approach using X-ray absorptiometric data from the patella of a young woman. , 1996, Bone.

[4]  A. Oberg,et al.  Does Reduced Skeletal Loading Account for Age‐Related Bone Loss? , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  G S Beaupré,et al.  Calcaneal loading during walking and running. , 2000, Medicine and science in sports and exercise.

[6]  T. Wren,et al.  Fat mass is not beneficial to bone in adolescents and young adults. , 2007, The Journal of clinical endocrinology and metabolism.

[7]  B. Weeks,et al.  Eight Months of Regular In‐School Jumping Improves Indices of Bone Strength in Adolescent Boys and Girls: The POWER PE Study , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  D B Burr,et al.  Muscle Strength, Bone Mass, and Age‐Related Bone Loss , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  H. Frost,et al.  On Our Age‐Related Bone Loss: Insights from a New Paradigm , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[10]  D. Cuthbertson The influence of prolonged muscular rest on metabolism. , 1929, The Biochemical journal.

[11]  T. Mittlmeier,et al.  Effects of mechanical loading on the profile of human femoral diaphyseal geometry. , 1994, Medical engineering & physics.

[12]  J. Challis,et al.  The influence of soft tissue movement on ground reaction forces, joint torques and joint reaction forces in drop landings. , 2006, Journal of biomechanics.

[13]  A. Gefen,et al.  Contribution of muscular weakness to osteoporosis: computational and animal models. , 2005, Clinical biomechanics.

[14]  M P Akhter,et al.  A noninvasive, in vivo model for studying strain adaptive bone modeling. , 1991, Bone.

[15]  R. Marcus,et al.  Differential effects of swimming versus weight‐bearing activity on bone mineral status of eumenorrheic athletes , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  P. B. Mack,et al.  Bone demineralization of foot and hand of gemini-titan IV, V and VII astronauts during orbital flight. , 1967, The American journal of roentgenology, radium therapy, and nuclear medicine.

[17]  P S Walker,et al.  Influence of muscle activity on the forces in the femur: an in vivo study. , 1997, Journal of biomechanics.

[18]  Heather A McKay,et al.  Bone mass and structure are enhanced following a 2-year randomized controlled trial of exercise in prepubertal boys. , 2004, Bone.

[19]  J. Kaprio,et al.  Heritability of BMD of Femoral Neck and Lumbar Spine: A Multivariate Twin Study of Finnish Men , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  L. Lanyon,et al.  The influence of strain rate on adaptive bone remodelling. , 1982, Journal of biomechanics.

[21]  Heather McKay,et al.  Bone strength and its determinants in pre- and early pubertal boys and girls. , 2006, Bone.

[22]  R. Marcus Relationship of age-related decreases in muscle mass and strength to skeletal status. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[23]  E Y Chao,et al.  Internal forces and moments in the femur during walking. , 1997, Journal of biomechanics.

[24]  R. Schwartz,et al.  Muscle forces or gravity: what predominates mechanical loading on bone? , 2009, Medicine and science in sports and exercise.

[25]  N. Crabtree,et al.  Ambulatory level and asymmetrical weight bearing after stroke affects bone loss in the upper and lower part of the femoral neck differently: bone adaptation after decreased mechanical loading. , 2000, Bone.

[26]  Christopher Ruff,et al.  Growth in bone strength, body size, and muscle size in a juvenile longitudinal sample. , 2003, Bone.

[27]  S. Bain,et al.  Botox induced muscle paralysis rapidly degrades bone. , 2006, Bone.

[28]  W. Kohrt,et al.  Effects of Exercise Involving Predominantly Either Joint‐Reaction or Ground‐Reaction Forces on Bone Mineral Density in Older Women , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  L. Lanyon,et al.  Regulation of bone formation by applied dynamic loads. , 1984, The Journal of bone and joint surgery. American volume.

[30]  M. Bouxsein,et al.  Muscle strength as a predictor of bone mineral density in young women , 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  R. Whalen,et al.  Bone mineral density, muscle strength, and recreational exercise in men , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  D. Bailey,et al.  The 'muscle-bone unit' during the pubertal growth spurt. , 2004, Bone.

[33]  P. B. Mack,et al.  Roentgenographic bone density changes in astronauts during representative Apollo space flight. , 1971, The American journal of roentgenology, radium therapy, and nuclear medicine.

[34]  D. Burr,et al.  The effects of muscle fatigue on bone strain. , 1994, The Journal of experimental biology.

[35]  I. Owan,et al.  Mechanotransduction in bone: role of strain rate. , 1995, The American journal of physiology.