Early Cerebral Small Vessel Disease and Brain Volume, Cognition, and Gait

Decline in cognitive function begins by the 40s, and may be related to future dementia risk. We used data from a community‐representative study to determine whether there are age‐related differences in simple cognitive and gait tests by the 40s, and whether these differences were associated with covert cerebrovascular disease on magnetic resonance imaging (MRI).

[1]  D. Harvey,et al.  Measures of brain morphology and infarction in the framingham heart study: establishing what is normal , 2005, Neurobiology of Aging.

[2]  Christina Wasylyshyn,et al.  Adult age and digit symbol substitution performance: a meta-analysis. , 2004, Psychology and aging.

[3]  P. Koudstaal,et al.  Silent brain infarcts: a systematic review , 2007, The Lancet Neurology.

[4]  Thomas E. Nichols,et al.  Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate , 2002, NeuroImage.

[5]  S. Pendlebury,et al.  Underestimation of Cognitive Impairment by Mini-Mental State Examination Versus the Montreal Cognitive Assessment in Patients With Transient Ischemic Attack and Stroke: A Population-Based Study , 2010, Stroke.

[6]  Evert F. S. van Velsen,et al.  Brain cortical thickness in the general elderly population: The Rotterdam Scan Study , 2013, Neuroscience Letters.

[7]  Jean-Philippe Thiran,et al.  Automatic quality assessment in structural brain magnetic resonance imaging , 2009, Magnetic resonance in medicine.

[8]  P. Matthews,et al.  White matter lesion progression, brain atrophy, and cognitive decline: The Austrian stroke prevention study , 2005, Annals of neurology.

[9]  Sudha Seshadri,et al.  Association of MRI Markers of Vascular Brain Injury With Incident Stroke, Mild Cognitive Impairment, Dementia, and Mortality: The Framingham Offspring Study , 2010, Stroke.

[10]  A. Hofman,et al.  Determinants of cerebellar and cerebral volume in the general elderly population , 2012, Neurobiology of Aging.

[11]  Matthijs Oudkerk,et al.  Incidence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study , 2003, Stroke.

[12]  Nick C Fox,et al.  Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration , 2013, The Lancet Neurology.

[13]  Anders M. Dale,et al.  An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest , 2006, NeuroImage.

[14]  Klaus P. Ebmeier,et al.  Timing of onset of cognitive decline: results from Whitehall II prospective cohort study , 2012, BMJ : British Medical Journal.

[15]  S. Black,et al.  National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards , 2006, Stroke.

[16]  Norbert Schuff,et al.  Measurement of MRI scanner performance with the ADNI phantom. , 2009, Medical physics.

[17]  P. Scheltens,et al.  2001–2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease? , 2011, Cerebrovascular Diseases.

[18]  Anders M. Dale,et al.  Reliability of MRI-derived measurements of human cerebral cortical thickness: The effects of field strength, scanner upgrade and manufacturer , 2006, NeuroImage.

[19]  L. Pantoni.  Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges , 2010, The Lancet Neurology.

[20]  K. Kohara,et al.  MTHFR Gene Polymorphism as a Risk Factor for Silent Brain Infarcts and White Matter Lesions in the Japanese General Population: The NILS-LSA Study , 2003, Stroke.

[21]  Richard W. Bohannon,et al.  Reference Values for the Timed Up and Go Test: A Descriptive Meta‐Analysis , 2006, Journal of geriatric physical therapy.

[22]  A. Hofman,et al.  Brain tissue volumes and small vessel disease in relation to the risk of mortality , 2009, Neurobiology of Aging.

[23]  Evan Fletcher,et al.  Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study , 2012, The Lancet Neurology.

[24]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[25]  O. Donoghue,et al.  Normative Values of Cognitive and Physical Function in Older Adults: Findings from The Irish Longitudinal Study on Ageing , 2013, Journal of the American Geriatrics Society.

[26]  Lewis H Kuller,et al.  Association Between Lower Digit Symbol Substitution Test Score and Slower Gait and Greater Risk of Mortality and of Developing Incident Disability in Well‐Functioning Older Adults , 2008, Journal of the American Geriatrics Society.

[27]  S. Yusuf,et al.  Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey , 2011, The Lancet.

[28]  Richard W. Bohannon.  Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. , 1997, Age and ageing.