INDUCTION OF INTERLEUKIN-6 BY PROTON BEAM IRRADIATION DEPENDS ON TARGETED ORGAN

Purpose: To determine whether proton beam irradiation induces the increase of IL-6 in plasma and which organ is most responsible for the irradiation. Methods and Materials: Ten to twelve week old mice received whole body or partial body proton beam irradiation. Slit shaped ports were implemented for partial irradiation in order to distinguish the response of a designated organ, head, lung, liver, and lower abdomen. The concentrations of IL-6 in plasma were assayed three and half days after the irradiation. Results: Whole body proton beam irradiation caused a significant elevation of IL-6 plasma levels the same as those occurred after photon beam irradiation. Partial proton beam irradiation explores the significant differences in the induction of IL-6 by the irradiated organ. Contrary to lung and head irradiation, lower abdominal irradiation and whole body irradiation lead the remarkable elevations of IL-6. Conclusion: Although IL-6 was induced by proton beam irradiation to lower abdomen and to the whole body, proton beam irradiation to the liver did not cause elevation of IL-6. Because proton beam can avoid irradiation to digestive organs responsible for IL-6 induction, proton beam therapy is supposed to be an effective treatment for hepatocellular carcinoma.

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