Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.

[1]  陶仲为 Sarcoidosis , 2009 .

[2]  A. Aguzzi,et al.  Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8 , 2008, The Journal of experimental medicine.

[3]  T. Junt,et al.  Restoration of lymphoid organ integrity through the interaction of lymphoid tissue–inducer cells with stroma of the T cell zone , 2008, Nature Immunology.

[4]  C. Julius,et al.  Prion strain discrimination in cell culture: The cell panel assay , 2007, Proceedings of the National Academy of Sciences.

[5]  B. Hinz,et al.  Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells , 2007, Nature Immunology.

[6]  J. Ernst,et al.  Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis. , 2007, The Journal of clinical investigation.

[7]  W. Schulz-Schaeffer,et al.  Accumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie , 2007, PLoS pathogens.

[8]  R. Bessen,et al.  Prion Infection of Muscle Cells In Vitro , 2007, Journal of Virology.

[9]  M. D. Di Bari,et al.  PrPSc in Salivary Glands of Scrapie-Affected Sheep , 2007, Journal of Virology.

[10]  F. Heppner,et al.  Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie , 2006, The Journal of Neuroscience.

[11]  Robert J Warren,et al.  Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease , 2006, Science.

[12]  Adriano Aguzzi,et al.  Pathogenesis of prion diseases: current status and future outlook , 2006, Nature Reviews Microbiology.

[13]  J. Miller,et al.  Abnormal Prion Protein in Ectopic Lymphoid Tissue in a Kidney of an Asymptomatic White-tailed Deer Experimentally Inoculated with the Agent of Chronic Wasting Disease , 2006, Veterinary pathology.

[14]  S. Liao,et al.  Lymphoid organ development: from ontogeny to neogenesis , 2006, Nature Immunology.

[15]  A. Aguzzi,et al.  Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease , 2005, The Lancet Neurology.

[16]  A. Aguzzi,et al.  PrPSc in mammary glands of sheep affected by scrapie and mastitis , 2005, Nature Medicine.

[17]  A. Aguzzi,et al.  Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion , 2005, Science.

[18]  I. Orme,et al.  Foamy Macrophages within Lung Granulomas of Mice Infected with Mycobacterium tuberculosis Express Molecules Characteristic of Dendritic Cells and Antiapoptotic Markers of the TNF Receptor-Associated Factor Family1 , 2005, The Journal of Immunology.

[19]  A. Aguzzi,et al.  Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions , 2005, Science.

[20]  F. Cohen,et al.  Synthetic Mammalian Prions , 2004, Science.

[21]  O. Andréoletti,et al.  PrPSc accumulation in myocytes from sheep incubating natural scrapie , 2004, Nature Medicine.

[22]  S. Nagata,et al.  Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice , 2004, Science.

[23]  I. Vorberg,et al.  Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. , 2004, The Journal of infectious diseases.

[24]  A. Aguzzi,et al.  Mammalian Prion Biology One Century of Evolving Concepts , 2004, Cell.

[25]  A. Aguzzi,et al.  Creutzfeldt–Jakob disease and inclusion body myositis: Abundant disease‐associated prion protein in muscle , 2004, Annals of neurology.

[26]  A. Aguzzi,et al.  Extraneural pathologic prion protein in sporadic Creutzfeldt-Jakob disease. , 2003, The New England journal of medicine.

[27]  F. Heppner,et al.  Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion , 2003, Nature.

[28]  L. Stoltze,et al.  A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  I. Mcconnell,et al.  Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility , 2003, Journal of Virology.

[30]  N. Mabbott,et al.  Temporary Blockade of the Tumor Necrosis Factor Receptor Signaling Pathway Impedes the Spread of Scrapie to the Brain , 2002, Journal of Virology.

[31]  B. Chesebro,et al.  Lymphotoxin-α- and Lymphotoxin-β-Deficient Mice Differ in Susceptibility to Scrapie: Evidence against Dendritic Cell Involvement in Neuroinvasion , 2002, Journal of Virology.

[32]  A. Aguzzi,et al.  Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[33]  A. Aguzzi,et al.  Efficient Lymphoreticular Prion Propagation Requires PrPc in Stromal and Hematopoietic Cells , 2001, Journal of Virology.

[34]  A. Aguzzi,et al.  B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  F. Mackay,et al.  Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie , 2000, Nature Medicine.

[36]  A. Aguzzi,et al.  Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. , 2000, Science.

[37]  A. Buschmann,et al.  A novel epitope for the specific detection of exogenous prion proteins in transgenic mice and transfected murine cell lines. , 1999, Virology.

[38]  A. Aguzzi,et al.  PrP expression in B lymphocytes is not required for prion neuroinvasion , 1998, Nature Medicine.

[39]  F. Mackay,et al.  Turning off follicular dendritic cells , 1998, Nature.

[40]  K. Pfeffer,et al.  The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. , 1998, Immunity.

[41]  A. Aguzzi,et al.  A crucial role for B cells in neuroinvasive scrapie , 1997, Nature.

[42]  A. Aguzzi,et al.  Prion research: the next frontiers , 1997, Nature.

[43]  A. Aguzzi,et al.  PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain , 1997, Nature.

[44]  F. Mackay,et al.  Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice , 1997, European journal of immunology.

[45]  Tomoko Nakanishi,et al.  ‘Green mice’ as a source of ubiquitous green cells , 1997, FEBS letters.

[46]  A. Aguzzi,et al.  Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie. , 1996, The EMBO journal.

[47]  A. Aguzzi,et al.  Normal host prion protein necessary for scrapie-induced neurotoxicity , 1996, Nature.

[48]  Richard C. Moore,et al.  Double Replacement Gene Targeting for the Production of a Series of Mouse Strains with Different Prion Protein Gene Alterations , 1995, Bio/Technology.

[49]  Scott F. Smith,et al.  Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. , 1994, Science.

[50]  A. Aguzzi,et al.  Mice devoid of PrP are resistant to scrapie , 1993, Cell.

[51]  S. Prusiner,et al.  Regional mapping of prion proteins in brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Mcwhir,et al.  Gene targeting using a mouse HPRT minigene/HPRT-deficient embryonic stem cell system: Inactivation of the mouseERCC-1 gene , 1992, Somatic cell and molecular genetics.

[53]  S. Prusiner,et al.  Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein , 1992, Nature.

[54]  S. Prusiner,et al.  Measurement of the scrapie agent using an incubation time interval assay , 1982, Annals of neurology.

[55]  H. Fraser,et al.  Pathogenesis of Scrapie in the Mouse: the Role of the Spleen , 1970, Nature.

[56]  P. Flint,et al.  Leprosy , 1903, The Indian medical gazette.

[57]  Jeppe Falsig,et al.  A versatile prion replication assay in organotypic brain slices , 2008, Nature Neuroscience.

[58]  David G. Russell,et al.  Who puts the tubercle in tuberculosis? , 2007, Nature Reviews Microbiology.

[59]  B. Chesebro,et al.  Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. , 2002, Journal of virology.