Formulation and Evaluation of Reconstitutable Oral Suspension of Ambroxol HCl and Azithromycin
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The objective of the present study was to develop dry suspensions for reconstitution like Azithromycin and Ambroxol HCl using powder blends techniques. No commercial product available in combined dosage form. Reconstitutable oral suspension show adequate chemical stability of the drug during shelf life, avoids the physical stability problems. These are dry mixture that requires the addition of water at the time of dispensing. The prepared suspensions were evaluated for flow properties, rheological and sedimentation behavior. The reconstitution oral suspensions of Azithromycin and Ambroxol HCl were found to be stable over its intended shelf life of 15 days after reconstitution. Formulation with Xanthum gum (1.5% and 0.75%) showed excellent sedimentation volume and degree of flocculation nearing 1. This was due to the presence of anti caking agents or the granule disintegrant added to the formulations. Also formulation with Acacia (3% and 1.5%) showed good redispersibility.
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