Interaction of Particles with Langmuir Monolayers of 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphocholine: A Matter of Chemistry?

Lipid layers are considered among the first protective barriers of the human body against pollutants, e.g., skin, lung surfactant, or tear film. This makes it necessary to explore the physico-chemical bases underlying the interaction of pollutants and lipid layers. This work evaluates using a pool of surface-sensitive techniques, the impact of carbon black and fumed silica particles on the behavior of Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). The results show that the incorporation of particles into the lipid monolayers affects the surface pressure–area isotherm of the DPPC, modifying both the phase behavior and the collapse conditions. This is explained considering that particles occupy a part of the area available for lipid organization, which affects the lateral organization of the lipid molecules, and consequently the cohesion interactions within the monolayer. Furthermore, particles incorporation worsens the mechanical performance of lipid layers, which may impact negatively in different processes presenting biological relevance. The modification induced by the particles has been found to be dependent on their specific chemical nature. This work tries to shed light on some of the most fundamental physico-chemical bases governing the interaction of pollutants with lipid layers, which plays an essential role on the design of strategies for preventing the potential health hazards associated with pollution.

[1]  Meng Li,et al.  Real-time monitoring of the effect of carbon nanoparticles on the surface behavior of DPPC/DPPG Langmuir monolayer. , 2020, Colloids and surfaces. B, Biointerfaces.

[2]  M. M. Velázquez,et al.  Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers , 2020 .

[3]  E. Guzmán,et al.  Colloids at Fluid Interfaces , 2019, Processes.

[4]  E. Guzmán,et al.  Influence of temperature on dynamic surface properties of spread DPPC monolayers in a broad range of surface pressures. , 2019, Chemistry and physics of lipids.

[5]  A. Cruz,et al.  The Lord of the Lungs: the essential role of pulmonary surfactant upon inhalation of nanoparticles. , 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[6]  T. Tetley,et al.  The method of depositing CeO2 nanoparticles onto a DPPC monolayer affects surface tension behaviour , 2019, NanoImpact.

[7]  Eduardo Guzmán,et al.  Lung surfactant-particles at fluid interfaces for toxicity assessments , 2019, Current Opinion in Colloid & Interface Science.

[8]  M. Bae,et al.  Differential toxicities of fine particulate matters from various sources , 2018, Scientific Reports.

[9]  Abdullah Khan,et al.  Silica Nanoparticle-Induced Structural Reorganizations in Pulmonary Surfactant Films: What Monolayer Compression Isotherms Do Not Say , 2018, ACS Applied Nano Materials.

[10]  E. Guzmán,et al.  Physico-chemical foundations of particle-laden fluid interfaces , 2018, The European Physical Journal E.

[11]  T. Sosnowski Particles on the lung surface - physicochemical and hydrodynamic effects , 2018, Current Opinion in Colloid & Interface Science.

[12]  Lijie Grace Zhang,et al.  Biophysical Assessment of Pulmonary Surfactant Predicts the Lung Toxicity of Nanomaterials , 2018 .

[13]  E. Guzmán,et al.  Effect of the Incorporation of Nanosized Titanium Dioxide on the Interfacial Properties of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers. , 2017, Langmuir : the ACS journal of surfaces and colloids.

[14]  J. Slater,et al.  Changes to DPPC Domain Structure in the Presence of Carbon Nanoparticles. , 2017, Langmuir : the ACS journal of surfaces and colloids.

[15]  G. Gompper,et al.  Nano- and microparticles at fluid and biological interfaces , 2017, Journal of physics. Condensed matter : an Institute of Physics journal.

[16]  Tomasz R. Sosnowski,et al.  New experimental model of pulmonary surfactant for biophysical studies , 2017 .

[17]  I. Momas,et al.  In vitro model adapted to the study of skin ageing induced by air pollution. , 2016, Toxicology letters.

[18]  M. Balali-Mood,et al.  Effects of air pollution on human health and practical measures for prevention in Iran , 2016, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[19]  S. Ye,et al.  Phase transition behaviors of the supported DPPC bilayer investigated by sum frequency generation (SFG) vibrational spectroscopy and atomic force microscopy (AFM). , 2016, Physical chemistry chemical physics : PCCP.

[20]  M. Spahr,et al.  Carbon Black as a Polymer Filler , 2016 .

[21]  J. Bouwstra,et al.  Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients. , 2016, Current problems in dermatology.

[22]  A. Farnoud,et al.  Calf Lung Surfactant Recovers Surface Functionality After Exposure to Aerosols Containing Polymeric Particles. , 2016, Journal of aerosol medicine and pulmonary drug delivery.

[23]  Eduardo Guzmán,et al.  2D dynamical arrest transition in a mixed nanoparticle-phospholipid layer studied in real and momentum spaces , 2015, Scientific Reports.

[24]  E. Guzmán,et al.  Effect of silica nanoparticles on the interfacial properties of a canonical lipid mixture. , 2015, Colloids and surfaces. B, Biointerfaces.

[25]  E. Guzmán,et al.  Interaction of Carbon Black Particles and Dipalmitoylphosphatidylcholine at the Water/Air Interface: Thermodynamics and Rheology , 2015 .

[26]  T. Sosnowski,et al.  Effect of clay nanoparticles on model lung surfactant: a potential marker of hazard from nanoaerosol inhalation , 2015, Environmental Science and Pollution Research.

[27]  E. Guzmán,et al.  Interfacial Properties of Mixed DPPC–Hydrophobic Fumed Silica Nanoparticle Layers , 2015 .

[28]  E. Guzmán,et al.  Particle and Particle-Surfactant Mixtures at Fluid Interfaces: Assembly, Morphology, and Rheological Description , 2015 .

[29]  Y. Zuo,et al.  Biophysical influence of airborne carbon nanomaterials on natural pulmonary surfactant. , 2015, ACS nano.

[30]  C. Case,et al.  Understanding nanoparticle cellular entry: A physicochemical perspective. , 2015, Advances in colloid and interface science.

[31]  M. FarnoudAmir,et al.  Calf Lung Surfactant Recovers Surface Functionality After Exposure to Aerosols Containing Polymeric Particles , 2015 .

[32]  C. Ruppert,et al.  Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: role of surfactant protein B and C. , 2014, Acta biomaterialia.

[33]  E. Guzmán,et al.  Two-dimensional DPPC based emulsion-like structures stabilized by silica nanoparticles. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[34]  H. Möhwald,et al.  Langmuir monolayers as models to study processes at membrane surfaces. , 2014, Advances in colloid and interface science.

[35]  J. Pérez-Gil,et al.  Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy. , 2014, Biochimica et biophysica acta.

[36]  L. Alados-Arboledas,et al.  Carbonaceous Particles in the Atmosphere: Experimental and Modelling Issues , 2014 .

[37]  V. Starov,et al.  Particle laden fluid interfaces: dynamics and interfacial rheology. , 2014, Advances in colloid and interface science.

[38]  M. Maskos,et al.  Size influences the effect of hydrophobic nanoparticles on lung surfactant model systems. , 2014, Biophysical journal.

[39]  C. Roland Reinforcement of Elastomers , 2014 .

[40]  A. Farnoud,et al.  Low concentrations of negatively charged sub-micron particles alter the microstructure of DPPC at the air–water interface , 2012 .

[41]  E. Guzmán,et al.  Influence of silica nanoparticles on phase behavior and structural properties of DPPC—Palmitic acid Langmuir monolayers , 2012 .

[42]  J. Pérez-Gil,et al.  Exposure to polymers reverses inhibition of pulmonary surfactant by serum, meconium, or cholesterol in the captive bubble surfactometer. , 2012, Biophysical journal.

[43]  L. Gradon,et al.  Alteration of surface properties of dipalmitoyl phosphatidylcholine by benzo[a]pyrene: a model of pulmonary effects of diesel exhaust inhalation. , 2012, Journal of biomedical nanotechnology.

[44]  C. Chiellini,et al.  Assessment of pollution impact on biological activity and structure of seabed bacterial communities in the Port of Livorno (Italy). , 2012, The Science of the total environment.

[45]  Anthony Seaton,et al.  A short history of the toxicology of inhaled particles , 2012, Particle and Fibre Toxicology.

[46]  E. Guzmán,et al.  Influence of silica nanoparticles on dilational rheology of DPPC–palmitic acid Langmuir monolayers , 2012 .

[47]  E. Guzmán,et al.  Effect of Hydrophilic and Hydrophobic Nanoparticles on the Surface Pressure Response of DPPC Monolayers , 2011 .

[48]  E. Guzmán,et al.  Wide-frequency dilational rheology investigation of mixed silica nanoparticle–CTAB interfacial layers , 2011 .

[49]  A. Ciajolo,et al.  Interfacial properties of carbon particulate-laden liquid interfaces and stability of related foams and emulsions , 2010 .

[50]  F. Monroy,et al.  Domain-growth kinetic origin of nonhorizontal phase coexistence plateaux in langmuir monolayers: compression rigidity of a Raft-like lipid distribution. , 2010, The journal of physical chemistry. B.

[51]  Zhining Wang,et al.  Effects of fullerenes on phospholipid membranes: a langmuir monolayer study. , 2009, Chemphyschem : a European journal of chemical physics and physical chemistry.

[52]  Zhining Wang,et al.  Studies of dipalmitoylphosphatidylcholine (DPPC) monolayers embedded with endohedral metallofullerene (Dy@C82). , 2009, Langmuir : the ACS journal of surfaces and colloids.

[53]  D. Grigoriev,et al.  Contact angle determination of micro- and nanoparticles at fluid/fluid interfaces: the excluded area concept. , 2007, Physical chemistry chemical physics : PCCP.

[54]  A. Mount,et al.  Translocation of C60 and its derivatives across a lipid bilayer. , 2007, Nano letters.

[55]  W. Rea,et al.  Adverse health effects of outdoor air pollutants. , 2006, Environment international.

[56]  L. Liggieri,et al.  Influence of surface processes on the dilational visco-elasticity of surfactant solutions. , 2005, Advances in colloid and interface science.

[57]  C. Ruppert,et al.  Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties , 2002, European Respiratory Journal.

[58]  A. Podǵorski,et al.  Deactivation of the pulmonary surfactant dynamics by toxic aerosols and gases. , 2001, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[59]  P. Dynarowicz-Łątka,et al.  Molecular interaction in mixed monolayers at the air/water interface , 1999 .

[60]  T. Vanderlick,et al.  Isotherms of Dipalmitoylphosphatidylcholine (DPPC) Monolayers: Features Revealed and Features Obscured , 1996 .

[61]  A. Podǵorski,et al.  Experimental and Theoretical Investigations of Transport Properties of DPPC Monolayer , 1996 .

[62]  G. Rayfield,et al.  Evidence for first-order phase transitions in lipid and fatty acid monolayers , 1992 .

[63]  A. Podǵorski,et al.  Hydrodynamical model of pulmonary clearance , 1989 .

[64]  S. Schürch,et al.  Surface tension at low lung volumes: dependence on time and alveolar size. , 1982, Respiration physiology.

[65]  D. Chapman,et al.  Monolayer characteristics of saturated 1,2,-diacyl phosphatidylcholines (lecithins) and phosphatidylethanolamines at the air-water interface. , 1968, Biochimica et biophysica acta.

[66]  G. Gaines,et al.  Insoluble Monolayers at Liquid-gas Interfaces , 1966 .