Catecholase and DNase activities of copper(II) complexes containing phenolate‐type ligands

Three new homodinuclear complexes containing substituted phenolate-type ligands based on the N5O2 donor (2-(N,N-Bis(2-pyridylmethyl)aminomethyl)-6-(N′,N′-(2-hydroxybenzyl)(2-pyridylmethyl))aminomethyl)-4-methylphenol (H2L-H) were synthesized and characterized by X-ray crystallography. Potentiometric titration studies in 70% (v/v) aqueous ethanol show that all three complexes exhibit a common {CuII(µ-phenoxo)(µ-OH)CuII(OH)} core in solution. Kinetic studies on the oxidation reaction of 3,5-di-tert-butylcatechol revealed that the catalytic activity of the metal complexes increases toward the ligand containing an electron-donating group. In addition, these complexes also carried out DNA cleavage by hydrolytic and oxidative pathways. Copyright © 2010 John Wiley & Sons, Ltd.

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