Investigating and Modelling Pituitary Endocrine Network Function

Endocrine cells in the mammalian pituitary are arranged into three‐dimensional homotypic networks that wire the gland and act to optimise hormone output by allowing the transmission of information between cell ensembles in a temporally precise manner. Despite this, the structure–function relationships that allow cells belonging to these networks to display coordinated activity remain relatively uncharacterised. This review discusses the recent technological advances that have allowed endocrine cell network structure and function to be probed and the mathematical models that can be used to analyse and present the resulting data. In particular, we focus on the mechanisms that allow endocrine cells to dynamically function as a population to drive hormone release as well as the experimental and theoretical methods that are used to track and model information flow through the network.

[1]  H. Urbanski,et al.  Developmental changes in the hormonal identity of gonadotroph cells in the rhesus monkey pituitary gland. , 2003, The Journal of clinical endocrinology and metabolism.

[2]  C. Denef,et al.  Interaction of alpha T3-1 cells with lactotropes and somatotropes of normal pituitary in vitro. , 1995, Neuroendocrinology.

[3]  R. Tsien,et al.  Circular permutation and receptor insertion within green fluorescent proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Edda Klipp,et al.  Systems Biology , 1994 .

[5]  J J Hopfield,et al.  Neural networks and physical systems with emergent collective computational abilities. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Brendon O. Watson,et al.  SLM Microscopy: Scanless Two-Photon Imaging and Photostimulation with Spatial Light Modulators , 2008, Frontiers in neural circuits.

[7]  K. Catt,et al.  Calcium oscillations in anterior pituitary cells. , 1992, Endocrine reviews.

[8]  C. Wollheim,et al.  Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials , 1987, Nature.

[9]  H. Christian,et al.  Lipocortin 1 (Annexin 1): A Candidate Paracrine Agent Localized in Pituitary Folliculo-Stellate Cells1. , 1999, Endocrinology.

[10]  A secreted fluorescent reporter targeted to pituitary growth hormone cells in transgenic mice. , 2000, Endocrinology.

[11]  P. Mollard,et al.  Synchronized Spontaneous Ca2+ Transients in Acute Anterior Pituitary Slices* , 1998, The Journal of Biological Chemistry.

[12]  Yoram Louzoun,et al.  Self-emergence of knowledge trees: extraction of the Wikipedia hierarchies. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[13]  M. Berridge,et al.  The versatility and universality of calcium signalling , 2000, Nature Reviews Molecular Cell Biology.

[14]  R. Yuste,et al.  Dynamics of Spontaneous Activity in Neocortical Slices , 2001, Neuron.

[15]  Yuji Ikegaya,et al.  Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity , 2004, Science.

[16]  Albert-László Barabási,et al.  Systems biology. Life's complexity pyramid. , 2002, Science.

[17]  Rafael Yuste.  Circuit Neuroscience: The Road Ahead , 2008, Front. Neurosci..

[18]  M. Hastings,et al.  Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin , 2002, Nature Neuroscience.

[19]  C Koch,et al.  Complexity and the nervous system. , 1999, Science.

[20]  J. Martin,et al.  Ultradian growth hormone rhythm in the rat: effects of feeding, hyperglycemia, and insulin-induced hypoglycemia. , 1976, Endocrinology.

[21]  P. Mollard,et al.  Hidden face of the anterior pituitary , 2002, Trends in Endocrinology & Metabolism.

[22]  Albert,et al.  Emergence of scaling in random networks , 1999, Science.

[23]  D J PRICE,et al.  NETWORKS OF SCIENTIFIC PAPERS. , 1965, Science.

[24]  I. Robinson,et al.  Different degrees of somatotroph ablation compromise pituitary growth hormone cell network structure and other pituitary endocrine cell types. , 2010, Endocrinology.

[25]  I. Robinson,et al.  Dual-Level Afferent Control of Growth Hormone-Releasing Hormone (GHRH) Neurons in GHRH–Green Fluorescent Protein Transgenic Mice , 2007, The Journal of Neuroscience.

[26]  I. Robinson,et al.  Autosomal dominant growth hormone deficiency disrupts secretory vesicles in vitro and in vivo in transgenic mice. , 2003, Endocrinology.

[27]  Derek de Solla Price,et al.  A general theory of bibliometric and other cumulative advantage processes , 1976, J. Am. Soc. Inf. Sci..

[28]  O. Sartor,et al.  Parallel studies of His-DTrp-Ala-Trp-DPhe-Lys-NH2 and human pancreatic growth hormone-releasing factor-44-NH2 in rat primary pituitary cell monolayer culture. , 1985, Endocrinology.

[29]  C. McArdle,et al.  Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases*S⃞ , 2008, Journal of Biological Chemistry.

[30]  C. Granger.  Investigating causal relations by econometric models and cross-spectral methods , 1969 .

[31]  N. Matsuki,et al.  Metastability of Active CA3 Networks , 2007, The Journal of Neuroscience.

[32]  Peter Lipp,et al.  Calcium - a life and death signal , 1998, Nature.

[33]  K Bauer,et al.  Folliculostellate cell network: A route for long-distance communication in the anterior pituitary , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[34]  D. MacGregor,et al.  Mathematical Modelling in Neuroendocrinology , 2008, Journal of neuroendocrinology.

[35]  Albert-László Barabási,et al.  Life's Complexity Pyramid , 2002, Science.

[36]  Albert-László Barabási,et al.  Scale-Free Networks: A Decade and Beyond , 2009, Science.

[37]  I. Robinson,et al.  Ghrelin Stimulation of Growth Hormone-Releasing Hormone Neurons Is Direct in the Arcuate Nucleus , 2010, PloS one.

[38]  Heinrich Spiecker,et al.  The power of single and multibeam two-photon microscopy for high-resolution and high-speed deep tissue and intravital imaging. , 2007, Biophysical journal.

[39]  C. Denef.  Paracrinicity: The Story of 30 Years of Cellular Pituitary Crosstalk , 2007, Journal of neuroendocrinology.

[40]  Rosa Cossart,et al.  A Parturition-Associated Nonsynaptic Coherent Activity Pattern in the Developing Hippocampus , 2007, Neuron.

[41]  A. Borst,et al.  A genetically encoded calcium indicator for chronic in vivo two-photon imaging , 2008, Nature Methods.

[42]  R. Yuste,et al.  Attractor dynamics of network UP states in the neocortex , 2003, Nature.

[43]  A. Barabasi,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[44]  Robert M Hoffman,et al.  Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. , 2009, Current opinion in biotechnology.

[45]  P. L. Le Tissier,et al.  Use of a prolactin-Cre/ROSA-YFP transgenic mouse provides no evidence for lactotroph transdifferentiation after weaning, or increase in lactotroph/somatotroph proportion in lactation , 2010, The Journal of endocrinology.

[46]  Nathalie L Rochefort,et al.  Sparsification of neuronal activity in the visual cortex at eye-opening , 2009, Proceedings of the National Academy of Sciences.

[47]  R. Zucker,et al.  Multiple calcium-dependent processes related to secretion in bovine chromaffin cells , 1993, Neuron.

[48]  I. Robinson,et al.  Cellular in vivo imaging reveals coordinated regulation of pituitary microcirculation and GH cell network function , 2010, Proceedings of the National Academy of Sciences.

[49]  Evelyn Fox Keller,et al.  Revisiting "scale-free" networks. , 2005, BioEssays : news and reviews in molecular, cellular and developmental biology.

[50]  J. Drouin,et al.  Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin. , 2008, Molecular endocrinology.

[51]  Michel A. Picardo,et al.  GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks , 2009, Science.

[52]  I. Robinson,et al.  Revealing the large-scale network organization of growth hormone-secreting cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Y. Lacasse,et al.  From the authors , 2005, European Respiratory Journal.

[54]  U. Boehm,et al.  Functional characterization of genetically labeled gonadotropes. , 2008, Endocrinology.

[55]  R. Tsien,et al.  A new generation of Ca2+ indicators with greatly improved fluorescence properties. , 1985, The Journal of biological chemistry.