Correlated studies of sense organs and nerves of the lateral‐line in living frog tadpoles. I. Regeneration of denervated organs

The opinion is widespread that nerves exert an important trophic influence on specialized structures, both motor and sensory, which they supply. F o r example, on the motor side it is known that skeletal muscles, deprived for a long time of their motor nerve supply, atrophy and ultimately degenerate. A familiar illustration of this is afforded by the shrunken limb musculature in human victims of severe poliomyelitis. A fine experimental study of the steps of muscle degeneration in the cat after denervation has been published by Tower ( ' 3 5 ) Thus, it is clear that an intact motor nerve supply is necessary for the continued maintenance of skeletal muscle in good condition. On the sensory side, however, conditions are much less clear. The principal question a t issue is whether or not a special sense organ is necessarily dependent upon its specific nerve supply for its maintenance. Other questions deal with the part played by nerves in the origin, growth, and regeneration of special sense organs Sharply contrasting views are held. One view, upheld particularly by Olmsted ('20a, '20b) and a number of later investigators, emphasizes the paramount importance of the

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