Temporal dynamics of the circadian heart rate following low and high volume exercise training in sedentary male subjects

PurposeIncreased risk of arrhythmic events occurs at certain times during the circadian cycle with the highest risk being in the second and fourth quarter of the day. Exercise improves treatment outcome in individuals with cardiovascular disease. How different exercise protocols affect the circadian rhythm and the associated decrease in adverse cardiovascular risk over the circadian cycle has not been shown.MethodsFifty sedentary male participants were randomized into an 8-week high volume and moderate volume training and a control group. Heart rate was recorded using Polar Electronics and investigated with Cosinor analysis and by Poincaré plot derived features of SD1, SD2 and the complex correlation measure (CCM) at 1-h intervals over the 24-h period.ResultsModerate exercise significantly increased vagal modulation and the temporal dynamics of the heart rate in the second quarter of the circadian cycle (p = 0.004 and p = 0.007 respectively). High volume exercise had a similar effect on vagal output (p = 0.003) and temporal dynamics (p = 0.003). Cosinor analysis confirms that the circadian heart rate displays a shift in the acrophage following moderate and high volume exercise from before waking (1st quarter) to after waking (2nd quarter of day).ConclusionsOur results suggest that exercise shifts vagal influence and increases temporal dynamics of the heart rate to the 2nd quarter of the day and suggest that this may be the underlying physiological change leading to a decrease in adverse arrhythmic events during this otherwise high-risk period.

[1]  Kuniaki Otsuka,et al.  Circadian heart rate and blood pressure variability considered for research and patient care. , 2003, International journal of cardiology.

[2]  J. B. Carter,et al.  Effect of Endurance Exercise on Autonomic Control of Heart Rate , 2003, Sports medicine.

[3]  F. Scheer,et al.  Existence of an Endogenous Circadian Blood Pressure Rhythm in Humans That Peaks in the Evening , 2011, Circulation research.

[4]  H Eugene Stanley,et al.  Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Seppo M. Nissilä,et al.  Heart rate dynamics after controlled training followed by a home-based exercise program , 2004, European Journal of Applied Physiology.

[6]  T. Seppänen,et al.  Quantitative beat-to-beat analysis of heart rate dynamics during exercise. , 1996, The American journal of physiology.

[7]  Q. Fang,et al.  Altered circadian rhythm of cardiac β3-adrenoceptor activity following myocardial infarction in the rat , 2010, Basic Research in Cardiology.

[8]  P M Okin,et al.  Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. , 1996, Circulation.

[9]  T. Moritani,et al.  Exercise training and autonomic nervous system activity in obese individuals. , 2001, Medicine and science in sports and exercise.

[10]  P Van Leeuwen,et al.  Circadian aspects of apparent correlation dimension in human heart rate dynamics. , 1995, The American journal of physiology.

[11]  C. Simon,et al.  Effects of increased training load on vagal-related indexes of heart rate variability: a novel sleep approach. , 2004, American journal of physiology. Heart and circulatory physiology.

[12]  D. Kripke,et al.  When people die. Cause of death versus time of death. , 1987, The American journal of medicine.

[13]  M. Unruh,et al.  Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[14]  H. Huikuri,et al.  Frequency of sudden cardiac death among acute myocardial infarction survivors with optimized medical and revascularization therapy. , 2006, The American journal of cardiology.

[15]  Y. Lecarpentier,et al.  PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways , 2010, PPAR research.

[16]  Phyllis K Stein,et al.  Circadian rhythm in the cardiovascular system: chronocardiology. , 2003, American heart journal.

[17]  Dietrich Büsselberg,et al.  Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease , 2013 .

[18]  A. Jeukendrup,et al.  Heart Rate Monitoring , 2003, Sports medicine.

[19]  S. Willich,et al.  Increased onset of sudden cardiac death in the first three hours after awakening. , 1992, The American journal of cardiology.

[20]  K M Kessler,et al.  Circadian rhythm of heart rate variability in survivors of cardiac arrest. , 1992, The American journal of cardiology.

[21]  M. Palaniswami,et al.  Complex Correlation Measure: a novel descriptor for Poincaré plot , 2009, BioMedical Engineering OnLine.

[22]  G. Tofler,et al.  Circadian rhythm and cardiovascular disease , 2009, Current atherosclerosis reports.

[23]  A. Tonkin,et al.  Poincaré plot of heart rate variability allows quantitative display of parasympathetic nervous activity in humans. , 1996, Clinical science.

[24]  R. Singh,et al.  Brain-heart connection and the risk of heart attack. , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[25]  Claire Médigue,et al.  Heart rate variability during exercise performed below and above ventilatory threshold. , 2004, Medicine and science in sports and exercise.

[26]  A. Malliani,et al.  Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. , 1990, Circulation.

[27]  Marimuthu Palaniswami,et al.  Sensitivity of temporal heart rate variability in Poincaré plot to changes in parasympathetic nervous system activity , 2011, Biomedical engineering online.

[28]  H. Kishida,et al.  Clinical significance and management of silent myocardial ischemia in patients with angina pectoris and myocardial infarction. , 1989, Japanese circulation journal.

[29]  Jason Ng,et al.  Assessment of parasympathetic reactivation after exercise. , 2006, American journal of physiology. Heart and circulatory physiology.

[30]  Kathryn Moynihan Ramsey,et al.  Circadian Rhythms and Metabolic Syndrome: From Experimental Genetics to Human Disease , 2010, Circulation research.

[31]  Guy A Dumont,et al.  A Circadian Rhythm in Heart Rate Variability Contributes to the Increased Cardiac Sympathovagal Response to Awakening in the Morning , 2012, Chronobiology international.

[32]  David S. Rosenbaum,et al.  Circadian rhythms govern cardiac repolarization and arrhythmogenesis , 2012, Nature.

[33]  Gavin Sandercock,et al.  Vigorous physical activity and vagal modulation in young adults , 2009, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[34]  Marimuthu Palaniswami,et al.  Poincaré plot interpretation using a physiological model of HRV based on a network of oscillators. , 2002, American journal of physiology. Heart and circulatory physiology.

[35]  Meena Kumari,et al.  Effects of moderate and vigorous physical activity on heart rate variability in a British study of civil servants. , 2003, American journal of epidemiology.

[36]  Marimuthu Palaniswami,et al.  Do existing measures of Poincare plot geometry reflect nonlinear features of heart rate variability? , 2001, IEEE Transactions on Biomedical Engineering.

[37]  Marimuthu Palaniswami,et al.  Association of cardiac autonomic neuropathy with alteration of sympatho-vagal balance through heart rate variability analysis. , 2010, Medical engineering & physics.

[38]  S. Viskin,et al.  Circadian variation of symptomatic paroxysmal atrial fibrillation. Data from almost 10 000 episodes. , 1999, European heart journal.

[39]  J. Thayer,et al.  The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. , 2010, International journal of cardiology.

[40]  A. Capucci,et al.  Autonomic nervous system in the genesis of arrhythmias in chronic heart failure: implication for risk stratification. , 2007, Minerva cardioangiologica.

[41]  G. Malfatto,et al.  Short and long term effects of exercise training on the tonic autonomic modulation of heart rate variability after myocardial infarction. , 1996, European heart journal.

[42]  Seppo M. Nissilä,et al.  Effects of Aerobic Training on Heart Rate Dynamics in Sedentary Subjects. , 2003, Journal of applied physiology.

[43]  P. Lavie,et al.  Correlation differences in heartbeat fluctuations during rest and exercise. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[44]  K M Kessler,et al.  Reproducibility and circadian rhythm of heart rate variability in healthy subjects. , 1990, The American journal of cardiology.

[45]  Franz Halberg,et al.  Circadian rhythmic fractal scaling of heart rate variability in health and coronary artery disease , 1997, Clinical cardiology.

[46]  D. Levy,et al.  Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study population. , 1987, The American journal of cardiology.

[47]  Martin Buchheit,et al.  Cardiac parasympathetic regulation: respective associations with cardiorespiratory fitness and training load. , 2006, American journal of physiology. Heart and circulatory physiology.

[48]  Martin Buchheit,et al.  Cardiac Parasympathetic Reactivation Following Exercise: Implications for Training Prescription , 2013, Sports Medicine.

[49]  F. Scheer,et al.  Impact of the human circadian system, exercise, and their interaction on cardiovascular function , 2010, Proceedings of the National Academy of Sciences.

[50]  Seppo M. Nissilä,et al.  Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects. , 2003, American journal of physiology. Heart and circulatory physiology.

[51]  G. Cornelissen,et al.  Chronobiologic optimization of exercise physiology and practice guided by heart rate variability , 1998 .

[52]  Xiaomin Liu,et al.  The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes , 2008, International journal of clinical practice.

[53]  R C Hermida,et al.  Chronobiological analysis techniques. Application to blood pressure , 2009, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[54]  D. Levy,et al.  Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. , 1996, Circulation.

[55]  T. Saikawa,et al.  Circadian rhythm of the signal averaged electrocardiogram and its relation to heart rate variability in healthy subjects , 1998, Heart.