Methyl 2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

In the title compound, C12H13NO5S, the thiazine ring adopts a half chair conformation and an intramolecular O—H⋯O hydrogen bond generates an S(6) ring. In the crystal, the molecules are linked by C—H⋯O interactions, leading to zigzag chains along the b axis.

[1]  Anthony L. Spek,et al.  Structure validation in chemical crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[2]  Robin Taylor,et al.  Mercury: visualization and analysis of crystal structures , 2006 .

[3]  I. Khan,et al.  Methyl 4-hydroxy-2-propyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide , 2009, Acta crystallographica. Section E, Structure reports online.

[4]  國郎 小笠原,et al.  Chem. Pharm. Bull.(オピニオン) , 2007 .

[5]  J. Mallamo,et al.  1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors , 2004 .

[6]  Louis J. Farrugia,et al.  WinGX suite for small-molecule single-crystal crystallography , 1999 .

[7]  H. Flack,et al.  On enantiomorph‐polarity estimation , 1983 .

[8]  良二 上田.  J. Appl. Cryst.の発刊に際して , 1970 .

[9]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[10]  H. Narjes,et al.  Interaction of Meloxicam with Cimetidine, Maalox, or Aspirin , 1996, Journal of clinical pharmacology.

[11]  G. Sheldrick.  A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[12]  Raymond E. Davis,et al.  Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in Crystals , 1995 .

[13]  Jamil Anwar Choudary,et al.  A facile synthesis of novel biologically active 4-hydroxy-N'-(benzylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxides. , 2009, European journal of medicinal chemistry.

[14]  Jamil Anwar Choudary,et al.  An Efficient Synthesis of 2-Alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides , 2005 .

[15]  Louis J. Farrugia,et al.  ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) , 1997 .

[16]  Muhammad Nadeem Arshad,et al.  Methyl 2-allyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide , 2009, Acta crystallographica. Section E, Structure reports online.

[17]  Leonard J. Barbour,et al.  X-Seed — A Software Tool for Supramolecular Crystallography , 2001 .