New Method for the Synthesis and Reactivity of (5‐R‐1,3,4‐Oxadiazol‐2‐yl)furoxans

A new, simple and general one-pot method for the preparation of (5-R-1,3,4-oxadiazol-2-yl)furoxans has been developed on the basis of the interaction between accessible 3-methylfuroxan-4-carboxylic acid hydrazide and aliphatic, aromatic and heterocyclic carboxylic acids or their chlorides in the presence of POCl3. The synthesis and study of (5-R-1,3,4-oxadiazol-2-yl)furoxans reactivity resulted in new polyheterocyclic ensembles incorporating furoxan, 1,3,4-oxadiazole, pyrrole, triazole, furan, thiophene, pyrimidine, and other heterocycles in different combinations.

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