In Vitro Study of the Effect of GK-101 on the Removal of Carious Material

pump delivery system has been previously shown (J Dent Res 53 (Special Issue): Abstract No. 281, 1974), the relative chemical effectiveness of GK-101 compared to an inactive solution such as saline has not yet been resolved. NChloroglycine is formed in situ when a sodium hypochlorite solution is mixed with glycine. The current study was designed to further assess the chemical efficacy of GK-101 in comparison to a buffer solution at a pH of 11.1 without N-chloroglycine and a normal saline solution. A single-blind investigation was instituted using 150 extracted carious teeth which were separated into three groups, with 50 teeth in each group. The teeth were assigned by random numbers to each of the three groups. This procedure would tend to equalize the distribution of size and type of lesions in each group. The carious teeth were treated four minutes after the solutions were prepared by directing a stream of liquid from a pulsating pump through