Dietary Natural Products for Prevention and Treatment of Liver Cancer

Liver cancer is the most common malignancy of the digestive system with high death rate. Accumulating evidences suggests that many dietary natural products are potential sources for prevention and treatment of liver cancer, such as grapes, black currant, plum, pomegranate, cruciferous vegetables, French beans, tomatoes, asparagus, garlic, turmeric, ginger, soy, rice bran, and some edible macro-fungi. These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs. This review summarizes the potential prevention and treatment activities of dietary natural products and their major bioactive constituents on liver cancer, and discusses possible mechanisms of action.

[1]  M. Adamkov,et al.  Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro , 2016, Nutrition and cancer.

[2]  E. Oroudjev,et al.  Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells. , 2010, Journal of medicinal food.

[3]  Jie Sun,et al.  Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells. , 2006, Cancer letters.

[4]  G. Kong,et al.  Dietary Intake of Soy Protein and Tofu in Association With Breast Cancer Risk Based on a Case-Control Study , 2008, Nutrition and cancer.

[5]  Jeongmin Lee,et al.  I3C and ICZ inhibit migration by suppressing the EMT process and FAK expression in breast cancer cells. , 2013, Molecular medicine reports.

[6]  G. Santoni,et al.  Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. , 2011, Carcinogenesis.

[7]  E. Schmelz,et al.  Selective Growth Inhibition of Human Breast Cancer Cells by Graviola Fruit Extract In Vitro and In Vivo Involving Downregulation of EGFR Expression , 2011, Nutrition and cancer.

[8]  Varsha Singh,et al.  Inhibition of Carcinogen-Induced DNA Damage in Rat Liver and Colon by Garlic Powders With Varying Alliin Content , 2006, Nutrition and cancer.

[9]  Mingjie Zhu,et al.  Does night work increase the risk of breast cancer? A systematic review and meta-analysis of epidemiological studies. , 2013, Cancer epidemiology.

[10]  C. la Vecchia,et al.  Fruit and vegetables and cancer risk: a review of southern European studies , 2015, British Journal of Nutrition.

[11]  Sei-Jung Lee,et al.  ZPDC glycoprotein (24 kDa) induces apoptosis and enhances activity of NK cells in N-nitrosodiethylamine-injected Balb/c. , 2014, Cellular immunology.

[12]  Ray Liu,et al.  6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. , 2007, Journal of agricultural and food chemistry.

[13]  C. Wiegand,et al.  Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein. , 2008, Basic & clinical pharmacology & toxicology.

[14]  S. Mousavi,et al.  Study of cytotoxic and apoptogenic properties of saffron extract in human cancer cell lines. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[15]  J. Lee,et al.  Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation. , 2011, International journal of oncology.

[16]  W. Helferich,et al.  Phytoestrogens and breast cancer: a complex story , 2008, Inflammopharmacology.

[17]  Kailee A. Johnson,et al.  Glycone-rich Soy Isoflavone Extracts Promote Estrogen Receptor Positive Breast Cancer Cell Growth , 2016, Nutrition and cancer.

[18]  Sedigheh Ganji-Harsini,et al.  Thymoquinone Could Increase The Efficacy of Tamoxifen Induced Apoptosis in Human Breast Cancer Cells: An In Vitro Study , 2016, Cell journal.

[19]  Xiaofeng Ma,et al.  Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells , 2014, Molecular Cancer.

[20]  G. Yen,et al.  Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion. , 2013, Molecular nutrition & food research.

[21]  F. Tsai,et al.  Zanthoxylum avicennae extracts induce cell apoptosis through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells and block tumor growth in xenografted nude mice. , 2011, International journal of molecular medicine.

[22]  A. Constantinou,et al.  Equol enhances tamoxifen’s anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells , 2013, BMC Cancer.

[23]  M. Ruiz-Larrea,et al.  Piper and Vismia Species from Colombian Amazonia Differentially Affect Cell Proliferation of Hepatocarcinoma Cells , 2014, Nutrients.

[24]  Shivendra V. Singh,et al.  Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells , 2012, PloS one.

[25]  X. Miao,et al.  Dietary Mushroom Intake May Reduce the Risk of Breast Cancer: Evidence from a Meta-Analysis of Observational Studies , 2014, PloS one.

[26]  Prachi Gupta,et al.  Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis. , 2013, Biochemical and biophysical research communications.

[27]  Shivendra V. Singh,et al.  Bim contributes to phenethyl isothiocyanate‐induced apoptosis in breast cancer cells , 2012, Molecular carcinogenesis.

[28]  Y. Ozturk,et al.  The antioxidant potency of Punica granatum L. Fruit peel reduces cell proliferation and induces apoptosis on breast cancer. , 2011, Journal of medicinal food.

[29]  Jong-Suk Kim,et al.  Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells , 2013, BMB reports.

[30]  S. Gollapudi,et al.  MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. , 2008, Cancer detection and prevention.

[31]  D. Bhatnagar,et al.  Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis. , 2007, Chemico-biological interactions.

[32]  Veronica M. W. Gee,et al.  Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. , 2011, Biochemical pharmacology.

[33]  H. Ling,et al.  6‐Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase‐9 expression via blockade of nuclear factor‐κB activation , 2010, British journal of pharmacology.

[34]  G. Bali,et al.  Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. , 2005, Fitoterapia.

[35]  R. Mehta,et al.  Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture , 2004, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[36]  K. Tsuta,et al.  Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. , 2001, Carcinogenesis.

[37]  Hong-Bin Kang,et al.  Positive effects of soy isoflavone food on survival of breast cancer patients in China. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[38]  S. Chien,et al.  Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction , 2011, Human & experimental toxicology.

[39]  T. Ng,et al.  A Bowman‐Birk trypsin inhibitor with antiproliferative activity from Hokkaido large black soybeans , 2008, Journal of peptide science : an official publication of the European Peptide Society.

[40]  H. Ishikawa,et al.  Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. , 2006, The Journal of nutrition.

[41]  Guimei Lin,et al.  Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy , 2014, BMC Complementary and Alternative Medicine.

[42]  M. Morris,et al.  Chemopreventive and anti‐angiogenic effects of dietary phenethyl isothiocyanate in an N‐methyl nitrosourea‐induced breast cancer animal model , 2013, Biopharmaceutics & drug disposition.

[43]  G. Firestone,et al.  Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells. , 2011, Carcinogenesis.

[44]  S. Fung,et al.  Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration , 2013, BMC Complementary and Alternative Medicine.

[45]  W. Hung,et al.  Indole-3-carbinol inhibits Sp1-induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells. , 2009, Journal of agricultural and food chemistry.

[46]  H. Bradlow.  Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. , 2008, In vivo.

[47]  Yukun Zhang,et al.  Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors , 2015, Clinical & Experimental Metastasis.

[48]  R. Schneider-Stock,et al.  Thymoquinone: fifty years of success in the battle against cancer models. , 2014, Drug discovery today.

[49]  Qin Chen,et al.  Inhibitory Effect of Antioxidant Extracts From Various Potatoes on the Proliferation of Human Colon and Liver Cancer Cells , 2011, Nutrition and cancer.

[50]  Zhidong Lv,et al.  Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo. , 2014, International journal of clinical and experimental pathology.

[51]  L. Bernstein,et al.  Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis , 2017, Breast Cancer Research.

[52]  Xiangjiu He,et al.  Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities. , 2007, Journal of agricultural and food chemistry.

[53]  Michele D. Sobolewski,et al.  Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines , 2007, Molecular Cancer Therapeutics.

[54]  S. Raghavan,et al.  Extracts of Strawberry Fruits Induce Intrinsic Pathway of Apoptosis in Breast Cancer Cells and Inhibits Tumor Progression in Mice , 2012, PloS one.

[55]  A. Sultan,et al.  Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells , 2009, Cancer biology & therapy.

[56]  Sung-Won Kim,et al.  Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study. , 2013, The American journal of clinical nutrition.

[57]  G. Brar,et al.  Indole-3-Carbinol (I3C) Inhibits Cyclin-dependent Kinase-2 Function in Human Breast Cancer Cells by Regulating the Size Distribution, Associated Cyclin E Forms, and Subcellular Localization of the CDK2 Protein Complex* , 2005, Journal of Biological Chemistry.

[58]  G. Sethi,et al.  Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS , 2013, PloS one.

[59]  S. Paik,et al.  The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. , 2005, Biological & pharmaceutical bulletin.

[60]  In‐Seon Lee,et al.  Inhibitory effects of methanol extract of plum (Prunus salicina L., cv. 'Soldam') fruits against benzo(alpha)pyrene-induced toxicity in mice. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[61]  K. Park,et al.  α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[62]  C. Belloir,et al.  Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[63]  D. Greenwood,et al.  Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies , 2012, Breast Cancer Research and Treatment.

[64]  Amanda B. Parris,et al.  Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells , 2016, International journal of oncology.

[65]  N. Baeshen,et al.  Differential Control of Growth, Apoptotic Activity, and Gene Expression in Human Breast Cancer Cells by Extracts Derived from Medicinal Herbs Zingiber officinale , 2012, Journal of biomedicine & biotechnology.

[66]  C. Porta,et al.  Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial. , 2012, Journal of hepatology.

[67]  Hua-Bin Li,et al.  Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. , 2012, Food & function.

[68]  T. Sun,et al.  Antitumor and antimetastatic activities of grape skin polyphenols in a murine model of breast cancer. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[69]  Yan-yun Zhu,et al.  Relationship between soy food intake and breast cancer in China. , 2011, Asian Pacific journal of cancer prevention : APJCP.

[70]  J. Wan,et al.  Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. , 2013, Toxicology letters.

[71]  A. Bishayee,et al.  Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/β-Catenin Signaling Pathways , 2015, Molecules.

[72]  L. Delphi,et al.  Apple pectin: A natural source for cancer suppression in 4T1 breast cancer cells in vitro and express p53 in mouse bearing 4T1 cancer tumors, in vivo. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[73]  P. Roca,et al.  The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment Depending on the ERα/ERβ Ratio , 2016, Journal of cellular biochemistry.

[74]  Lloyd J. Old,et al.  The roles of IFNγ in protection against tumor development and cancer immunoediting , 2002 .

[75]  J. Yun,et al.  Momordica Charantia lectin exhibits antitumor activity towards hepatocellular carcinoma , 2014, Investigational New Drugs.

[76]  B. Henderson,et al.  Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: The Multiethnic Cohort Study , 2014, International journal of cancer.

[77]  N. K. Hung,et al.  Inhibition of tumor growth and angiogenesis by water extract of Gac fruit (Momordica cochinchinensis Spreng). , 2005, International journal of oncology.

[78]  N. Jeppsson,et al.  Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea buckthorn (Hippophae rhamnoides L.) during maturation. , 2000, Journal of agricultural and food chemistry.

[79]  K. Reddy,et al.  Triple-negative breast cancers: an updated review on treatment options. , 2011, Current oncology.

[80]  Jing-Gung Chung,et al.  Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy. , 2013, Journal of agricultural and food chemistry.

[81]  Hyung Gyun Kim,et al.  Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells. , 2013, Food chemistry.

[82]  Hua-Bin Li,et al.  Antioxidant Capacities and Total Phenolic Contents of 56 Wild Fruits from South China , 2010, Molecules.

[83]  I. Saiki,et al.  Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells. , 2014, Anticancer research.

[84]  G. Grosso,et al.  A comprehensive meta‐analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations , 2017, Molecular nutrition & food research.

[85]  N. Seeram,et al.  Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. , 2006, Journal of agricultural and food chemistry.

[86]  Simon C Watkins,et al.  Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. , 2016, Mitochondrion.

[87]  E. Giovannucci,et al.  Possible role of diet in cancer: systematic review and multiple meta‐analyses of dietary patterns, lifestyle factors, and cancer risk , 2017, Nutrition reviews.

[88]  W. Foulkes,et al.  Hereditary breast cancer: new genetic developments, new therapeutic avenues , 2008, Human Genetics.

[89]  Ayaz Ahmad,et al.  Rice bran phytic acid induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[90]  C. Nagata.  Factors to Consider in the Association Between Soy Isoflavone Intake and Breast Cancer Risk , 2010, Journal of epidemiology.

[91]  C. Weinberg,et al.  Gestational diabetes mellitus may be associated with increased risk of breast cancer , 2017, British Journal of Cancer.

[92]  A. Alshatwi,et al.  Roles of p53 and caspases in induction of apoptosis in MCF- 7 breast cancer cells treated with a methanolic extract of Nigella sativa seeds. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[93]  P. L. Lua,et al.  Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. , 2015, Complementary therapies in medicine.

[94]  Jun-xia Zhao,et al.  Iso-suillin isolated from Suillus luteus, induces G1 phase arrest and apoptosis in human hepatoma SMMC-7721 cells. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[95]  M. Gidley,et al.  Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells , 2015, Food Science and Biotechnology.

[96]  M. Lila,et al.  Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions. , 2005, Journal of agricultural and food chemistry.

[97]  F. Abas,et al.  Novel molecular, cytotoxical, and immunological study on promising and selective anticancer activity of Mung bean sprouts , 2012, BMC Complementary and Alternative Medicine.

[98]  C. Sung,et al.  Induction of apoptosis by immature fruits of Prunus salicina Lindl. cv. Soldam in MDA-MB-231 human breast cancer cells , 2007, International journal of food sciences and nutrition.

[99]  H. Viernstein,et al.  Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway. , 2013, Food Chemistry.

[100]  B. Patil,et al.  Effects of a Carrot Juice Intervention on Plasma Carotenoids, Oxidative Stress, and Inflammation in Overweight Breast Cancer Survivors , 2012, Nutrition and cancer.

[101]  Myong-Jo Kim,et al.  Hwanggeumchal sorghum Induces Cell Cycle Arrest, and Suppresses Tumor Growth and Metastasis through Jak2/STAT Pathways in Breast Cancer Xenografts , 2012, PloS one.

[102]  Mouming Zhao,et al.  Immunomodulatory and anticancer activities of phenolics from Garcinia mangostana fruit pericarp. , 2009 .

[103]  Y. Surh,et al.  Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. , 1998, Cancer letters.

[104]  M. Morris,et al.  Dietary Organic Isothiocyanates are Cytotoxic in Human Breast Cancer MCF-7 and Mammary Epithelial MCF-12A Cell Lines , 2004, Experimental biology and medicine.

[105]  R. Mansel,et al.  Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer , 2002, Breast Cancer Research and Treatment.

[106]  H. Lee,et al.  Induction of quinone reductase by allylisothiocyanate (AITC) and the N‐acetylcysteine conjugate of AITC in Hepa1c1c7 mouse hepatoma cells , 2006, BioFactors.

[107]  N. Hansen,et al.  Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial , 2012, Cancer Prevention Research.

[108]  S. Narod.  Hormone replacement therapy and the risk of breast cancer , 2011, Nature Reviews Clinical Oncology.

[109]  Minhua Wen,et al.  Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathway , 2012, Journal of Asian natural products research.

[110]  Zhiwei Wang,et al.  Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. , 2006, Cancer research.

[111]  M. Fanelli,et al.  Inhibition of Breast Cancer Cell Proliferation and In Vitro Tumorigenesis by a New Red Apple Cultivar , 2015, PloS one.

[112]  S. Kim,et al.  Cytotoxic effect of buckwheat (Fagopyrum esculentum Moench) hull against cancer cells. , 2007, Journal of medicinal food.

[113]  Y. Zhang,et al.  Antioxidant capacities and total phenolic contents of 62 fruits. , 2011, Food chemistry.

[114]  H. Adlercreutz,et al.  Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a japanese population in comparison with dietary records and blood and urine isoflavones. , 2001, The Journal of nutrition.

[115]  Gopal Chakrabarti,et al.  Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[116]  Qi Xie,et al.  Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells , 2014, Genes, chromosomes & cancer.

[117]  Andrew H. Beck,et al.  Reproductive risk factors in relation to molecular subtypes of breast cancer: Results from the nurses' health studies , 2016, International journal of cancer.

[118]  In‐Seon Lee,et al.  Induction of apoptosis by immature plum in human hepatocellular carcinoma. , 2009, Journal of medicinal food.

[119]  R. Liu,et al.  Cranberry phytochemicals: Isolation, structure elucidation, and their antiproliferative and antioxidant activities. , 2006, Journal of agricultural and food chemistry.

[120]  P. Roca,et al.  Genistein Modulates Proliferation and Mitochondrial Functionality in Breast Cancer Cells Depending on ERalpha/ERbeta Ratio , 2014, Journal of cellular biochemistry.

[121]  In-Seon Lee,et al.  Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells. , 2005, Journal of agricultural and food chemistry.

[122]  R. Banjerdpongchai,et al.  Cytotoxic and apoptotic-inducing effects of purple rice extracts and chemotherapeutic drugs on human cancer cell lines. , 2013, Asian Pacific journal of cancer prevention : APJCP.

[123]  Yuanting Gu,et al.  Consumption of vegetables and fruits and breast cancer survival: a systematic review and meta-analysis , 2017, Scientific Reports.

[124]  M. Salama,et al.  Effect of lifestyle and reproductive factors on the onset of breast cancer in female BRCA 1 and 2 mutation carriers , 2015, Molecular genetics & genomic medicine.

[125]  X. Shu,et al.  Long‐term soy consumption and tumor tissue MicroRNA and gene expression in triple‐negative breast cancer , 2016, Cancer.

[126]  Qing Yuan,et al.  Pleurotus eous polysaccharides suppress angiogenesis and induce apoptosis via ROS-dependent JNK activation and mitochondrial mediated mechanisms in MCF-7 human breast cancer cells , 2015 .

[127]  Xiaoyu Liu,et al.  Anticancer effects of deproteinized asparagus polysaccharide on hepatocellular carcinoma in vitro and in vivo , 2014, Tumor Biology.

[128]  Yucui Jin.  3,3′-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation , 2011, Molecular and Cellular Biochemistry.

[129]  Xiang Li,et al.  Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. , 2012, Journal of ethnopharmacology.

[130]  Wen-Chao Liu,et al.  Anti-hepatoma activity and mechanism of corn silk polysaccharides in H22 tumor-bearing mice. , 2014, International journal of biological macromolecules.

[131]  Eun Young Seo,et al.  [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. , 2008, The Journal of nutritional biochemistry.

[132]  S. Chittur,et al.  Antiproliferative effects of pomegranate extract in MCF‐7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks , 2014, Molecular carcinogenesis.

[133]  D. Barnes,et al.  Phytochemical composition and biological activity of 8 varieties of radish (Raphanus sativus L.) sprouts and mature taproots. , 2011, Journal of food science.

[134]  Kezhen Lv,et al.  Cruciferous vegetables intake is inversely associated with risk of breast cancer: a meta-analysis. , 2013, Breast.

[135]  K. Akimoto,et al.  Inhibitory Effect of Agaricu blazei Murill Components on Abnormal Collagen Fiber Formation in Human Hepatocarcinoma Cells , 2008, Bioscience, biotechnology, and biochemistry.

[136]  Tomo Sasaki,et al.  Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice. , 2011, Oncology reports.

[137]  A. Rasedee,et al.  Oxidative Stress-Mediated Apoptosis Induced by Ethanolic Mango Seed Extract in Cultured Estrogen Receptor Positive Breast Cancer MCF-7 Cells , 2015, International journal of molecular sciences.

[138]  Robert T. Taylor,et al.  CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. , 2008, Cancer letters.

[139]  G. Firestone,et al.  Indole‐3‐carbinol inhibits MDA‐MB‐231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity , 2009, International journal of cancer.

[140]  L. Goya,et al.  Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). , 2005, Journal of agricultural and food chemistry.

[141]  K. Kang,et al.  Polysaccharides from Korean Citrus hallabong peels inhibit angiogenesis and breast cancer cell migration. , 2016, International journal of biological macromolecules.

[142]  X. Shu,et al.  Soy food consumption is associated with lower risk of coronary heart disease in Chinese women. , 2003, The Journal of nutrition.

[143]  HongJin Lee,et al.  A daidzein metabolite, 6,7,4′-trihydroxyisoflavone inhibits cellular proliferation through cell cycle arrest and apoptosis induction in MCF10CA1a human breast cancer cells , 2013, Journal of the Korean Society for Applied Biological Chemistry.

[144]  M. Salvador,et al.  Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- ol vitis labrusca extract. , 2013, Anti-cancer agents in medicinal chemistry.

[145]  Hua-Bin Li,et al.  Spices for Prevention and Treatment of Cancers , 2016, Nutrients.

[146]  S. Costantini,et al.  Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L.) Seed Oil on Breast Cancer Cell Lines , 2014, Molecules.

[147]  Qing-qing Wang,et al.  Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model , 2012, Acta Pharmacologica Sinica.

[148]  Alana D. Steffen,et al.  Dietary isoflavone intake is not statistically significantly associated with breast cancer risk in the Multiethnic Cohort , 2014, British Journal of Nutrition.

[149]  K. Saravanakumar,et al.  The antiproliferative activity of 3-deoxyanthocyanins extracted from red sorghum (Sorghum bicolor) bran through P(53)-dependent and Bcl-2 gene expression in breast cancer cell line. , 2013, Life sciences.

[150]  T. Ng,et al.  A new Phaseolus vulgaris lectin induces selective toxicity on human liver carcinoma Hep G2 cells , 2011, Archives of Toxicology.

[151]  D. Barnes,et al.  Aqueous extract from Spanish black radish (Raphanus sativus L. Var. niger) induces detoxification enzymes in the HepG2 human hepatoma cell line. , 2007, Journal of agricultural and food chemistry.

[152]  E. Rosen,et al.  Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes , 2000, Journal of Molecular Medicine.

[153]  B. Karlan,et al.  Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway , 2010, Oncogene.

[154]  Charles M Perou,et al.  Systems biology and genomics of breast cancer. , 2011, Cold Spring Harbor perspectives in biology.

[155]  P. Cheung,et al.  Extract of Pleurotus pulmonarius Suppresses Liver Cancer Development and Progression through Inhibition of VEGF-Induced PI3K/AKT Signaling Pathway , 2012, PloS one.

[156]  S. Hong,et al.  10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. , 2016, Oncology reports.

[157]  Hua-Bin Li,et al.  Antiproliferative activities of tea and herbal infusions. , 2013, Food & function.

[158]  S. Mertens-Talcott,et al.  Pyrogallol, an absorbable microbial gallotannins-metabolite and mango polyphenols (Mangifera Indica L.) suppress breast cancer ductal carcinoma in situ proliferation in vitro. , 2016, Food & function.

[159]  N. Karamanos,et al.  Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. , 2007, Anticancer research.

[160]  Jae-Yong Lee,et al.  Benzyl isothiocyanate inhibits basal and hepatocyte growth factor-stimulated migration of breast cancer cells , 2011, Molecular and Cellular Biochemistry.

[161]  F. Cheng,et al.  Grain phytic acid content in japonica rice as affected by cultivar and environment and its relation to protein content , 2005 .

[162]  Reshmi Chatterjee,et al.  An overview of effective therapies and recent advances in biomarkers for chronic liver diseases and associated liver cancer. , 2015, International immunopharmacology.

[163]  Jing-Gung Chung,et al.  Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract. , 2011, In vivo.

[164]  X. Shu,et al.  Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. , 2012, The American journal of clinical nutrition.

[165]  K. Wada,et al.  Soy isoflavone intake and breast cancer risk in Japan: From the Takayama study , 2013, International journal of cancer.

[166]  L. Cantley,et al.  Apoptosis: A Bad kinase makes good , 1997, Nature.

[167]  A. S. Darvesh,et al.  Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats. , 2011, The Journal of nutritional biochemistry.

[168]  Zhiwei Chen,et al.  The Effect of Curcumin on Breast Cancer Cells , 2013, Journal of breast cancer.

[169]  Y. Tung,et al.  Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. , 2011, Journal of agricultural and food chemistry.

[170]  G. Firestone,et al.  3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells. , 2013, The Journal of nutritional biochemistry.

[171]  Chi-Chen Lin,et al.  Inhibitory effect of clove methanolic extract and eugenol on dendritic cell functions , 2016 .

[172]  F. Sarkar,et al.  Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. , 2005, Cancer research.

[173]  A. Mahdi,et al.  Anticancer and Antioxidant activity of Zingiber officinale Roscoe rhizome. , 2016, Indian journal of experimental biology.

[174]  In‐Seon Lee,et al.  Inhibitory effect of immature plum on PMA-induced MMP-9 expression in human hepatocellular carcinoma , 2009, Natural product research.

[175]  A. S. Darvesh,et al.  Anthocyanin-Rich Black Currant Extract Suppresses the Growth of Human Hepatocellular Carcinoma Cells , 2010, Natural product communications.

[176]  A. Jemal,et al.  Breast Cancer Statistics , 2013 .

[177]  Robert J. White,et al.  Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein , 2015, BMC Cancer.

[178]  T. Matsuzaki,et al.  Wasabi-Derived 6-(Methylsulfinyl)Hexyl Isothiocyanate Induces Apoptosis in Human Breast Cancer by Possible Involvement of the NF-κB Pathways , 2014, Nutrition and cancer.

[179]  N. Arora,et al.  Lycopene mediated modulation of 7,12 Dimethlybenz (a) anthracene induced hepatic clastogenicity in male Balb/c mice. , 2010, Nutricion hospitalaria.

[180]  S. Sengupta,et al.  6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death , 2015, PloS one.

[181]  A. Tang,et al.  Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer. , 2010, International journal of oncology.

[182]  A. Jemal,et al.  Breast cancer statistics, 2013 , 2014, CA: a cancer journal for clinicians.

[183]  H. Rupasinghe,et al.  Flavonoid-Enriched Apple Fraction AF4 Induces Cell Cycle Arrest, DNA Topoisomerase II Inhibition, and Apoptosis in Human Liver Cancer HepG2 Cells , 2014, Nutrition and cancer.

[184]  K. McGuire,et al.  3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells. , 2006, The Journal of surgical research.

[185]  F. Tsai,et al.  Suppression of Plasminogen Activators and the MMP-2/-9 Pathway by a Zanthoxylum avicennae Extract to Inhibit the HA22T Human Hepatocellular Carcinoma Cell Migration and Invasion Effects in Vitro and in Vivo via Phosphatase 2A Activation , 2013, Bioscience, biotechnology, and biochemistry.

[186]  Xiaofeng He,et al.  Consumption of vegetables may reduce the risk of liver cancer: results from a meta-analysis of case-control and cohort studies. , 2015, Clinics and research in hepatology and gastroenterology.

[187]  G. Firestone,et al.  3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. , 2002, Carcinogenesis.

[188]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[189]  Mark A Pereira,et al.  Soy intake and risk of type 2 diabetes mellitus in Chinese Singaporeans , 2011, European Journal of Nutrition.

[190]  Jing Wang,et al.  Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells , 2016, International journal of oncology.

[191]  F. Tsai,et al.  Zanthoxylum avicennae extracts inhibit cell proliferation through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells in vitro and in vivo. , 2012, International journal of molecular medicine.

[192]  A. Abdo,et al.  Ginger ingredients inhibit the development of diethylnitrosoamine induced premalignant phenotype in rat chemical hepatocarcinogenesis model , 2010, BioFactors.

[193]  G. Calaf,et al.  Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines. , 2016, International journal of oncology.

[194]  G. Bar-Sela,et al.  Wheat Grass Juice May Improve Hematological Toxicity Related to Chemotherapy in Breast Cancer Patients: A Pilot Study , 2007, Nutrition and cancer.

[195]  C. Ioannides,et al.  4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent , 2011, Archives of Toxicology.

[196]  Sonia Sharma,et al.  Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development. , 2005, Cancer letters.

[197]  Y. Akao,et al.  α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation , 2011, BMC medicine.

[198]  C. Giordano,et al.  Natural Products as Promising Antitumoral Agents in Breast Cancer: Mechanisms of Action and Molecular Targets. , 2016, Mini reviews in medicinal chemistry.

[199]  A. Davenport,et al.  Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells. , 2015, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.

[200]  M. Lila,et al.  Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia and non-cancerous PK15 kidney cells. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[201]  M. Hou,et al.  6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells. , 2010, Molecular nutrition & food research.

[202]  Ching-Hsein Chen,et al.  Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[203]  S. Mertens-Talcott,et al.  Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: role of the PI3K/AKT pathway and associated microRNAs. , 2015, Nutrition research.

[204]  Chiwon W. Lee,et al.  In Vitro Study on Effect of Germinated Wheat on Human Breast Cancer Cells , 2016 .

[205]  Hua-Bin Li,et al.  Bioactivities and Health Benefits of Mushrooms Mainly from China , 2016, Molecules.

[206]  G. Yen,et al.  Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. , 2010, Molecular nutrition & food research.

[207]  David Heber,et al.  Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro , 2010, Cancer Prevention Research.

[208]  N. Vidhya,et al.  Induction of apoptosis by eugenol in human breast cancer cells. , 2011, Indian journal of experimental biology.

[209]  Xingbin Yang,et al.  Evaluation of antioxidative and antitumor activities of extracted flavonoids from Pink Lady apples in human colon and breast cancer cell lines. , 2015, Food & function.

[210]  Xinru Wang,et al.  Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway. , 2008, Toxicology in vitro : an international journal published in association with BIBRA.

[211]  D. Hoskin,et al.  Piperine inhibits the growth and motility of triple-negative breast cancer cells. , 2015, Cancer letters.

[212]  Zhiwei Wang,et al.  Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model , 2006, Molecular Cancer Therapeutics.

[213]  Hua-Bin Li,et al.  Biological Activities of Polyphenols from Grapes , 2010, International journal of molecular sciences.

[214]  A. Rasedee,et al.  Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract , 2015, BMC Complementary and Alternative Medicine.

[215]  N. Seeram,et al.  Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. , 2009, Journal of agricultural and food chemistry.

[216]  J. Hohmann,et al.  Black currant phytoconstituents exert chemoprevention of diethylnitrosamine‐initiated hepatocarcinogenesis by suppression of the inflammatory response , 2013, Molecular carcinogenesis.

[217]  Shivendra V. Singh,et al.  Benzyl isothiocyanate–induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak , 2006, Molecular Cancer Therapeutics.

[218]  E. Jeffery,et al.  Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells. , 2005, Journal of medicinal food.

[219]  J. Wan,et al.  Diallyl disulfide inhibits growth and metastatic potential of human triple-negative breast cancer cells through inactivation of the β-catenin signaling pathway. , 2015, Molecular nutrition & food research.

[220]  M. R. Kim,et al.  Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[221]  M. Gidekel,et al.  Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth. , 2012, Journal of medicinal food.

[222]  T. Norikura,et al.  p-terphenyl derivatives from the mushroom Thelephora aurantiotincta suppress the proliferation of human hepatocellular carcinoma cells via iron chelation. , 2013, Journal of agricultural and food chemistry.

[223]  Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition. , 2014, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[224]  G. Firestone,et al.  Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells. , 2004, Carcinogenesis.

[225]  Zhaoyi Wang,et al.  Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells. , 2009, Oncology reports.

[226]  G. Firestone,et al.  3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. , 2006, Cancer research.

[227]  N. Nalini,et al.  Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer. , 2005, Clinica chimica acta; international journal of clinical chemistry.

[228]  Xingbin Yang,et al.  ROS-Dependent Mitochondria Molecular Mechanisms Underlying Antitumor Activity of Pleurotus abalonus Acidic Polysaccharides in Human Breast Cancer MCF-7 Cells , 2013, PloS one.

[229]  T. Hasuma,et al.  Combination of Zizyphus jujuba and green tea extracts exerts excellent cytotoxic activity in HepG2 cells via reducing the expression of APRIL. , 2009, The American journal of Chinese medicine.

[230]  N. Sareen,et al.  Reproductive factors and breast cancer: a case-control study in tertiary care hospital of North India. , 2013, Indian journal of cancer.

[231]  Zheng-Tao Wang,et al.  In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells. , 2006, Pharmacological research.

[232]  L. R. Ribeiro,et al.  β-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2 , 2008, Archives of Toxicology.

[233]  E. Xia,et al.  Potential of Fruit Wastes as Natural Resources of Bioactive Compounds , 2012, International journal of molecular sciences.

[234]  Ling-Ling Yang,et al.  Antitumour and free radical scavenging effects of γ‐mangostin isolated from Garcinia mangostana pericarps against hepatocellular carcinoma cell , 2013, The Journal of pharmacy and pharmacology.

[235]  Hua-Bin Li,et al.  Natural Polyphenols for Prevention and Treatment of Cancer , 2016, Nutrients.

[236]  M. Cazzaniga,et al.  Breast Cancer Chemoprevention: Old and New Approaches , 2012, Journal of biomedicine & biotechnology.

[237]  W. Liu,et al.  Asparanin A induces G(2)/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. , 2009, Biochemical and biophysical research communications.

[238]  T. Ng,et al.  Characterisation of a haemagglutinin from Hokkaido red bean (Phaseolus vulgaris cv. Hokkaido red bean). , 2010, Journal of the science of food and agriculture.

[239]  Y. Tzeng,et al.  Methyl Antcinate A Suppresses the Population of Cancer Stem-Like Cells in MCF7 Human Breast Cancer Cell Line , 2013, Molecules.

[240]  M. A. Hossain,et al.  Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells. , 2010, Nutrition research.

[241]  P. Paśko,et al.  Rutabaga (Brassica napus L. var. napobrassica) seeds, roots, and sprouts: a novel kind of food with antioxidant properties and proapoptotic potential in Hep G2 hepatoma cell line. , 2013, Journal of medicinal food.

[242]  R. Depping,et al.  Curcumin Decreases Survival of Hep3B Liver and MCF-7 Breast Cancer Cells , 2011, Strahlentherapie und Onkologie.

[243]  S. Merajver,et al.  Pomegranate Fruit Extract Impairs Invasion and Motility in Human Breast Cancer , 2009, Integrative cancer therapies.

[244]  W. Ahn,et al.  Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. , 2004, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.

[245]  F. Hernández,et al.  Polyphenolic compounds, anthocyanins and antioxidant activity of nineteen pomegranate fruits: A rich source of bioactive compounds , 2016 .

[246]  G. Yen,et al.  Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics , 2005, Free radical research.

[247]  Shivendra V. Singh,et al.  Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3. , 2011, Carcinogenesis.

[248]  R. Russell,et al.  Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis‐promoted hepatocarcinogenesis in rats , 2010, International journal of cancer.

[249]  M. Pierobon,et al.  Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis , 2012, Breast Cancer Research and Treatment.

[250]  J. Corton,et al.  Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β. , 1998, Endocrinology.

[251]  S. Pyo,et al.  Allicin inhibits invasion and migration of breast cancer cells through the suppression of VCAM-1: Regulation of association between p65 and ER-α , 2015 .

[252]  X. Liang,et al.  Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma. , 2015, Cancer letters.

[253]  J. Yang,et al.  Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways. , 2013, Neoplasma.

[254]  Jessica Tang,et al.  Hesperidin suppressed proliferations of both Human breast cancer and androgen‐dependent prostate cancer cells , 2010, Phytotherapy research : PTR.

[255]  W. Willett,et al.  Fruit and vegetable consumption in adolescence and early adulthood and risk of breast cancer: population based cohort study , 2016, British Medical Journal.

[256]  A. Vollmar,et al.  Analytical method for appreciation of garlic therapeutic potential and for validation of a new formulation. , 2005, Journal of pharmaceutical and biomedical analysis.

[257]  V. Speirs,et al.  Phyto-oestrogens and breast cancer chemoprevention , 2004, Breast Cancer Research.

[258]  K. Nakagawa,et al.  Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells. , 2014, Food chemistry.

[259]  S. Mukherjee,et al.  Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target , 2016, Free radical research.

[260]  Zhiyong Luo,et al.  A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein. , 2016, Carbohydrate polymers.

[261]  Yuzhu Cao,et al.  Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways , 2015, PloS one.

[262]  B. Goliaei,et al.  Equol as a potent radiosensitizer in estrogen receptor-positive and -negative human breast cancer cell lines , 2015, Breast Cancer.

[263]  J. Clements,et al.  Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression , 2007, Journal of cellular physiology.

[264]  Xianting Ding,et al.  Curcumin in Treating Breast Cancer , 2016, Journal of laboratory automation.

[265]  M. Penichet,et al.  Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer , 2012, Breast Cancer Research and Treatment.

[266]  K. Grandien,et al.  Printed in U.S.A. Copyright © 1997 by The Endocrine Society Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors � and � , 2022 .

[267]  J. Hong,et al.  Potential therapeutic effects of functionally active compounds isolated from garlic. , 2014, Pharmacology & therapeutics.

[268]  C. Hudis,et al.  Triple-negative breast cancer: an unmet medical need. , 2011, The oncologist.

[269]  M. Mandal,et al.  Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. , 2013, Life sciences.

[270]  Y. Kao,et al.  White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. , 2001, The Journal of nutrition.

[271]  Michael G. Johnson,et al.  Human colon and liver cancer cell proliferation inhibition by peptide hydrolysates derived from heat-stabilized defatted rice bran. , 2008, Journal of agricultural and food chemistry.

[272]  H. Moon,et al.  Chemopreventive Effect of Curcuma longa Linn on Liver Pathology in HBx Transgenic Mice , 2011, Integrative cancer therapies.

[273]  G. Firestone,et al.  Indole-3-carbinol Inhibits CDK6 Expression in Human MCF-7 Breast Cancer Cells by Disrupting Sp1 Transcription Factor Interactions with a Composite Element in the CDK6 Gene Promoter* , 2001, The Journal of Biological Chemistry.

[274]  A. Bishayee,et al.  Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. , 2013, The Journal of nutritional biochemistry.

[275]  Takuji Tanaka,et al.  Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats. , 2005, Oncology reports.

[276]  L. Kong,et al.  Steroids from the roots of Asparagus officinalis and their cytotoxic activity. , 2008, Journal of integrative plant biology.

[277]  F. Sheu,et al.  Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma. , 2010, International immunopharmacology.

[278]  Chen Chen,et al.  Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice. , 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[279]  S. Kambhampati,et al.  Pomegranate sensitizes Tamoxifen action in ER-α positive breast cancer cells , 2011, Journal of Cell Communication and Signaling.

[280]  Q. Hu,et al.  Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii. , 2014, Journal of the science of food and agriculture.

[281]  Luis Cisneros-Zevallos,et al.  Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo. , 2014, The Journal of nutritional biochemistry.

[282]  G. Firestone,et al.  DIM stimulates IFNγ gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways , 2005, Oncogene.

[283]  S. Fan,et al.  A Garlic Derivative, S-allylcysteine (SAC), Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma , 2012, PloS one.

[284]  C. Teng,et al.  Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells. , 2012, Journal of agricultural and food chemistry.

[285]  K. Bajbouj,et al.  Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma , 2011, Hepatology.

[286]  Adrian V. Lee,et al.  Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide* , 2016, The Journal of Biological Chemistry.

[287]  M. Friedman,et al.  Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells. , 2009, Journal of agricultural and food chemistry.

[288]  F. Liu,et al.  Isolation of a polysaccharide with antiproliferative, hypoglycemic, antioxidant and HIV‐1 reverse transcriptase inhibitory activities from the fruiting bodies of the abalone mushroom Pleurotus abalonus , 2011, The Journal of pharmacy and pharmacology.

[289]  G. Kong,et al.  A case–control study on the dietary intake of mushrooms and breast cancer risk among Korean women , 2008, International journal of cancer.

[290]  P. Roca,et al.  Genistein modulates oxidative stress in breast cancer cell lines according to ERα/ERβ ratio: effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes. , 2013, The international journal of biochemistry & cell biology.

[291]  Yun Lu,et al.  Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi. , 2011, Hepatobiliary & pancreatic diseases international : HBPD INT.

[292]  Jeongseon Kim,et al.  Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status , 2012, Nutrition and cancer.

[293]  Hua-Bin Li,et al.  Antiproliferative activity of peels, pulps and seeds of 61 fruits , 2013 .

[294]  Shivendra V. Singh,et al.  Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate , 2010, Molecular carcinogenesis.

[295]  C. Giordano,et al.  Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. , 2012, Journal of ethnopharmacology.

[296]  G. Firestone,et al.  Indole-3-Carbinol disrupts Estrogen Receptor-alpha dependent expression of Insulin-like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and proliferation of human breast cancer cells , 2012, Molecular and Cellular Endocrinology.

[297]  R. Liu,et al.  Effect of 2alpha-hydroxyursolic acid on NF-kappaB activation induced by TNF-alpha in human breast cancer MCF-7 cells. , 2008, Journal of agricultural and food chemistry.

[298]  Anwar Anwar-mohamed,et al.  Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. , 2009, Cancer letters.

[299]  Zhiwei Wang,et al.  Inactivation of NF-κB by 3,3′-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells , 2007, Molecular Cancer Therapeutics.

[300]  Seon-Mi Yu,et al.  Thymoquinone (TQ) regulates cyclooxygenase-2 expression and prostaglandin E2 production through PI3kinase (PI3K)/p38 kinase pathway in human breast cancer cell line, MDA-MB-231 , 2012 .

[301]  F. Sarkar,et al.  Translocation of Bax to mitochondria induces apoptotic cell death in Indole-3-carbinol (I3C) treated breast cancer cells , 2000, Oncogene.

[302]  Yuan Zhang,et al.  Phenolic Compounds and Bioactivities of Pigmented Rice , 2013, Critical reviews in food science and nutrition.

[303]  J. Hsu,et al.  Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5. , 2012, Journal of agricultural and food chemistry.

[304]  M. R. Toloi,et al.  Biotransformed Soybean Extract Induces Cell Death of Estrogen-Dependent Breast Cancer Cells by Modulation of Apoptotic Proteins , 2015, Nutrition and cancer.

[305]  R. Rohanizadeh,et al.  Molecular Mechanisms of Anti-metastatic Activity of Curcumin. , 2016, Anticancer research.

[306]  H. Lee,et al.  Allyl Isothiocyanate and Its N-Acetylcysteine Conjugate Suppress Metastasis via Inhibition of Invasion, Migration, and Matrix Metalloproteinase-2/-9 Activities in SK-Hep1 Human Hepatoma Cells , 2006, Experimental biology and medicine.

[307]  A. Munshi,et al.  Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. , 2011, Asian Pacific journal of cancer prevention : APJCP.

[308]  R. Liu,et al.  Effect of selected phytochemicals and apple extracts on NF-kappaB activation in human breast cancer MCF-7 cells. , 2007, Journal of agricultural and food chemistry.

[309]  R. Gan,et al.  Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases , 2015, Molecules.

[310]  S. Cho,et al.  Induction of apoptosis in anoikis-resistant breast cancer stem cells by supercritical CO2 extracts from Citrus hassaku Hort ex Tanaka , 2014, Journal of the Korean Society for Applied Biological Chemistry.

[311]  J. Coebergh,et al.  Increased consumption of fruit and vegetables and future cancer incidence in selected European countries. , 2010, European journal of cancer.

[312]  K. Singletary,et al.  Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane. , 2009, The Journal of nutritional biochemistry.

[313]  Y. Akao,et al.  Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. , 2009, Anticancer research.

[314]  J. Tsai,et al.  Eosinophil apoptosis induced by fungal immunomodulatory peptide-fve via reducing IL-5alpha receptor. , 2007, Journal of the Formosan Medical Association = Taiwan yi zhi.

[315]  Yu Qin,et al.  Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies. , 2013, Asia Pacific journal of clinical nutrition.

[316]  Lianhong Li,et al.  Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway , 2013, Stem Cell Research & Therapy.

[317]  R. Liu,et al.  Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation. , 2008, Journal of agricultural and food chemistry.

[318]  Doaa A. Ali,et al.  Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. , 2014, Anticancer research.

[319]  Yiwei Li,et al.  Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells. , 2003, The Journal of nutrition.

[320]  T. Ng,et al.  Isolation and characterization of a French bean hemagglutinin with antitumor, antifungal, and anti-HIV-1 reverse transcriptase activities and an exceptionally high yield. , 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[321]  E. Ho,et al.  Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies. , 2016, Nutrition reviews.

[322]  S. Thorgeirsson,et al.  Functional and genetic deconstruction of the cellular origin in liver cancer , 2015, Nature Reviews Cancer.

[323]  A. Cheung,et al.  Water Extract from Pleurotus pulmonarius with Antioxidant Activity Exerts In Vivo Chemoprophylaxis and Chemosensitization for Liver Cancer , 2014, Nutrition and cancer.

[324]  Z. Ismail,et al.  Proapoptotic and antimetastatic properties of supercritical CO2 extract of Nigella sativa Linn. against breast cancer cells. , 2013, Journal of medicinal food.

[325]  D. Greenwood,et al.  Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

[326]  S. Kuo,et al.  Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. , 2009, Oncology reports.

[327]  Xiao-yong Lei,et al.  Apoptosis induced by diallyl disulfide in human breast cancer cell line MCF-7 , 2008, Acta Pharmacologica Sinica.

[328]  Do-Hee Kim,et al.  Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1. , 2012, Biochemical pharmacology.

[329]  J. Xue,et al.  Synergistic cytotoxic effect of genistein and doxorubicin on drug-resistant human breast cancer MCF-7/Adr cells. , 2014, Oncology reports.

[330]  Yuquan Wei,et al.  Potential anticancer activity of litchi fruit pericarp extract against hepatocellular carcinoma in vitro and in vivo. , 2006, Cancer letters.

[331]  Peri Nagappan,et al.  Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells. , 2015, Carcinogenesis.

[332]  Muzeyyen Arslan,et al.  Oral intake of ginger for chemotherapy-induced nausea and vomiting among women with breast cancer. , 2015, Clinical journal of oncology nursing.

[333]  A. Gaikwad,et al.  Curcumin as an adjuvant to breast cancer treatment. , 2015, Anti-cancer agents in medicinal chemistry.

[334]  T. Hasuma,et al.  Green tea extract enhances the selective cytotoxic activity of Zizyphus jujuba extracts in HepG2 cells. , 2008, The American journal of Chinese medicine.

[335]  M. Koo,et al.  Influence of water-soluble extracts of long-term fermented Doenjang on bone metabolism bioactivity and breast cancer suppression , 2016, Food Science and Biotechnology.

[336]  E. Nevo,et al.  Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. , 2011, Carcinogenesis.

[337]  Prachi Gupta,et al.  Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system. , 2013, Chemico-biological interactions.

[338]  G. Hortobagyi,et al.  Advances in the Treatment of Breast Cancer , 2008, Clinical pharmacology and therapeutics.

[339]  U. Kandalam,et al.  Bromelain-induced apoptosis in GI-101A breast cancer cells. , 2012, Journal of medicinal food.

[340]  Jian Chen,et al.  Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells. , 2015, Food & function.

[341]  F. Kluxen,et al.  Genistein modulates the anti-tumor activity of cisplatin in MCF-7 breast and HT-29 colon cancer cells , 2014, Archives of Toxicology.

[342]  Y. Shukla,et al.  Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice. , 2007, Molecular nutrition & food research.

[343]  Prachi Gupta,et al.  Spectroscopic Characterization of Lycopene Extract from Lycopersicum esculentum (Tomato) and Its Evaluation as a Chemopreventive Agent Against Experimental Hepatocarcinogenesis in Mice , 2013, Phytotherapy research : PTR.

[344]  J. Palmer,et al.  Diabetes and breast cancer mortality in Black women , 2016, Cancer Causes & Control.

[345]  A. Balapure,et al.  Genistein synergizes centchroman action in human breast cancer cells , 2016, Indian journal of pharmacology.

[346]  G. Wani,et al.  Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. , 2011, Mutation research.

[347]  A. Podsędek,et al.  Flavanols from Japanese Quince (Chaenomeles Japonica) Fruit Inhibit Human Prostate and Breast Cancer Cell Line Invasiveness and Cause Favorable Changes in Bax/Bcl-2 mRNA Ratio , 2013, Nutrition and cancer.

[348]  H. Tokuda,et al.  Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. , 2011, Anti-cancer agents in medicinal chemistry.

[349]  T. Pawlik,et al.  Intrahepatic cholangiocarcinoma: An international, multi-institutional analysis of prognostic factors and lymph node assessment. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[350]  S. Ishikawa,et al.  Direct cytotoxicity of Lentinula edodes mycelia extract on human hepatocellular carcinoma cell line. , 2012, Biological & pharmaceutical bulletin.

[351]  S. Safe,et al.  Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation , 2012, Breast Cancer Research and Treatment.

[352]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[353]  Li-tao Yang,et al.  Asparagus polysaccharide and gum with hepatic artery embolization induces tumor growth and inhibits angiogenesis in an orthotopic hepatocellular carcinoma model. , 2015, Asian Pacific journal of cancer prevention : APJCP.

[354]  Chibo Hong,et al.  Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. , 2002, Biochemical pharmacology.

[355]  L. Pusztai,et al.  Gene expression profiling in breast cancer: classification, prognostication, and prediction , 2011, The Lancet.

[356]  C. Rock,et al.  Vegetable intake is associated with reduced breast cancer recurrence in tamoxifen users: a secondary analysis from the Women’s Healthy Eating and Living Study , 2010, Breast Cancer Research and Treatment.

[357]  A. Aboussekhra,et al.  Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation , 2013, BMC Cancer.

[358]  L. Qin,et al.  Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies , 2010, Breast Cancer Research and Treatment.

[359]  M. Sedlák,et al.  Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. , 2002, Biochemical and biophysical research communications.

[360]  Lin Zhang,et al.  In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells. , 2012, The international journal of biochemistry & cell biology.

[361]  P. Gál,et al.  Soy and Breast Cancer: Focus on Angiogenesis , 2015, International journal of molecular sciences.

[362]  R. Liu,et al.  Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. , 2009, Journal of agricultural and food chemistry.

[363]  Yasmin Anum Mohd Yusof,et al.  Ginger Extract (Zingiber Officinale) has Anti-Cancer and Anti-Inflammatory Effects on Ethionine-Induced Hepatoma Rats , 2008, Clinics.

[364]  Feng Xu,et al.  An Updated Meta-Analysis of Randomized Controlled Trials Assessing the Effect of Sorafenib in Advanced Hepatocellular Carcinoma , 2014, PloS one.

[365]  N. Karadaǧ,et al.  Apricot attenuates oxidative stress and modulates of Bax, Bcl-2, caspases, NFκ-B, AP-1, CREB expression of rats bearing DMBA-induced liver damage and treated with a combination of radiotherapy. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[366]  B. Trock,et al.  Meta-analysis of soy intake and breast cancer risk. , 2006, Journal of the National Cancer Institute.

[367]  R. Wu,et al.  Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. , 2013, Asian Pacific Journal of Cancer Prevention.

[368]  Shivendra V. Singh,et al.  Diallyl trisulfide inhibits estrogen receptor-α activity in human breast cancer cells , 2014, Breast Cancer Research and Treatment.

[369]  S. Andrews,et al.  Diallyl Disulfide-Induced Apoptosis in a Breast-Cancer Cell Line (MCF-7) May Be Caused by Inhibition of Histone Deacetylation , 2012, Nutrition and cancer.

[370]  Qing-Han Gao,et al.  The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. , 2013, Journal of agricultural and food chemistry.

[371]  J. Lee,et al.  Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. , 2010, Cancer letters.

[372]  Shivendra V. Singh,et al.  Benzyl Isothiocyanate Inhibits Epithelial-Mesenchymal Transition in Cultured and Xenografted Human Breast Cancer Cells , 2011, Cancer Prevention Research.

[373]  J. P. Rigalli,et al.  The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. , 2016, Cancer letters.

[374]  T. Tollefsbol,et al.  Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines , 2010, PloS one.

[375]  G. Paliyath,et al.  Treatment of mcf-7 breast cancer cells with a red grape wine polyphenol fraction results in disruption of calcium homeostasis and cell cycle arrest causing selective cytotoxicity. , 2006, Journal of Agricultural and Food Chemistry.

[376]  G. Filomeni,et al.  Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells. , 2006, The Journal of nutritional biochemistry.

[377]  N. Kosem,et al.  Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. , 2004, Journal of ethnopharmacology.

[378]  Yong-jie Wu,et al.  Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. , 2005, Die Pharmazie.

[379]  M. Asghari-Jafarabadi,et al.  Associations between Dietary Allium Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study , 2016, Journal of breast cancer.

[380]  Tong Zhou,et al.  Bioactivities and Health Benefits of Wild Fruits , 2016, International journal of molecular sciences.

[381]  S. Fukushima,et al.  Aged garlic extract inhibits development of putative preneoplastic lesions in rat hepatocarcinogenesis. , 2006, The Journal of nutrition.

[382]  A. Ramírez de Molina,et al.  Modulation of estrogen and epidermal growth factor receptors by rosemary extract in breast cancer cells , 2014, Electrophoresis.

[383]  H. Rokita,et al.  The effects of garlic‐derived sulfur compounds on cell proliferation, caspase 3 activity, thiol levels and anaerobic sulfur metabolism in human hepatoblastoma HepG2 cells , 2012, Cell biochemistry and function.

[384]  R. Watanapokasin,et al.  Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. , 2016, International journal of oncology.

[385]  I. Rowland,et al.  Daidzein, R-(+)equol and S-(−)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2 , 2014, European Journal of Nutrition.

[386]  Li-li Feng,et al.  Effect of grape procyanidins on tumor angiogenesis in liver cancer xenograft models. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[387]  Xs Feng,et al.  Effects of Soy Isoflavone and Endogenous Oestrogen on Breast Cancer in MMTV-erbB2 Transgenic Mice , 2012, The Journal of international medical research.

[388]  J. Hohmann,et al.  Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. , 2012, Current cancer drug targets.

[389]  Jing Wang,et al.  Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo. , 2006, Toxicology and applied pharmacology.

[390]  D. Kouretas,et al.  Influence of potent antioxidant leguminosae family plant extracts on growth and antioxidant defense system of Hep2 cancer cell line. , 2010, Journal of medicinal food.

[391]  J. Awika,et al.  Sorghum phytochemicals and their potential impact on human health. , 2004, Phytochemistry.

[392]  M. Bizzarri,et al.  Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion , 2013, European Journal of Nutrition.

[393]  Shuai Jiang,et al.  A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine , 2012, The Biochemical journal.

[394]  A. Jemal,et al.  Cancer statistics, 2017 , 2017, CA: a cancer journal for clinicians.

[395]  B. Henderson,et al.  The Effects of Soy Consumption before Diagnosis on Breast Cancer Survival: The Multiethnic Cohort Study , 2013, Nutrition and cancer.

[396]  Yanlin Wang,et al.  Development of novel application of 3,3′-diindolylmethane: sensitizing multidrug resistance human breast cancer cells to γ-irradiation , 2016, Pharmaceutical biology.

[397]  P. Cordopatis,et al.  Crocetin Inhibits Invasiveness of MDA‐MB‐231 Breast Cancer Cells via Downregulation of Matrix Metalloproteinases , 2010, Planta medica.

[398]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[399]  Banu Iskender,et al.  The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer , 2016, Tumor Biology.

[400]  Z. Tian,et al.  Diarylheptanoids from the rhizomes of Alpinia officinarum and their anticancer activity. , 2008, Fitoterapia.

[401]  Robert C. G. Martin,et al.  Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma , 2013, International journal of oncology.

[402]  Y. Moon,et al.  Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer Cells , 2010, Evidence-based complementary and alternative medicine : eCAM.

[403]  T. Ng,et al.  A trypsin-chymotrypsin inhibitor with antiproliferative activity from small glossy black soybeans. , 2009, Planta Medica.

[404]  Gianfranco Piva,et al.  Carnosic acid from rosemary extracts: a potential chemoprotective agent against aflatoxin B1. An in vitro study , 2007, Journal of applied toxicology : JAT.

[405]  M. Failla,et al.  Biological Activities and Bioavailability of Mangosteen Xanthones: A Critical Review of the Current Evidence , 2013, Nutrients.

[406]  Ans Punt,et al.  Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[407]  J. Bae,et al.  Citrus Fruit Intake and Breast Cancer Risk: A Quantitative Systematic Review , 2013, Journal of breast cancer.

[408]  M. Iinuma,et al.  Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp , 2012, Journal of biomedicine & biotechnology.

[409]  X. Shu,et al.  The association of soy food consumption with the risk of subtype of breast cancers defined by hormone receptor and HER2 status , 2016, International journal of cancer.

[410]  Shivendra V. Singh,et al.  Dietary Chemopreventative Benzyl Isothiocyanate Inhibits Breast Cancer Stem Cells In Vitro and In Vivo , 2013, Cancer Prevention Research.

[411]  T. Ng,et al.  The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo. , 2012, Cancer letters.

[412]  Shivendra V. Singh,et al.  p53-Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression , 2010, Cancer Prevention Research.

[413]  V. Vijaya Padma,et al.  Induction of apoptosis by ginger in HEp-2 cell line is mediated by reactive oxygen species. , 2007, Basic & clinical pharmacology & toxicology.

[414]  K. Kang,et al.  Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells , 2007, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[415]  R. Liu,et al.  2α-Hydroxyursolic Acid Inhibited Cell Proliferation and Induced Apoptosis in MDA-MB-231 Human Breast Cancer Cells through the p38/MAPK Signal Transduction Pathway. , 2016, Journal of agricultural and food chemistry.

[416]  Wenbin Zhou,et al.  Genistein inhibits MDA-MB-231 triple-negative breast cancer cell growth by inhibiting NF-κB activity via the Notch-1 pathway. , 2012, International journal of molecular medicine.

[417]  Chandra E. Baker,et al.  Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model. , 2015, Molecular nutrition & food research.

[418]  Ying Wang,et al.  Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway. , 2013, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[419]  Marcy J. Balunas,et al.  Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. , 2008, Journal of natural products.

[420]  Qipeng Yuan,et al.  Sulforaphene inhibits triple negative breast cancer through activating tumor suppressor Egr1 , 2016, Breast Cancer Research and Treatment.

[421]  Peng Liu,et al.  Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a , 2014, PloS one.

[422]  M. Abedini,et al.  Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells , 2016, Avicenna journal of phytomedicine.