The EGF receptor as central transducer of heterologous signalling systems.

[1]  R. Lefkowitz,et al.  Regulation of tyrosine kinase cascades by G-protein-coupled receptors. , 1999, Current opinion in cell biology.

[2]  A. Ullrich,et al.  Epidermal growth factor receptors: critical mediators of multiple receptor pathways. , 1999, Current opinion in cell biology.

[3]  M. Maa,et al.  c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function* , 1999, The Journal of Biological Chemistry.

[4]  S. Parsons,et al.  Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Caron,et al.  Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. , 1999, Science.

[6]  G. Plowman,et al.  The discovery and validation of new drug targets in cancer. , 1998, Current opinion in biotechnology.

[7]  L. Silengo,et al.  Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion‐dependent cell survival , 1998, The EMBO journal.

[8]  K. Barrett,et al.  Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion. , 1998, The Journal of biological chemistry.

[9]  J. Gutkind,et al.  Cell growth control by G protein-coupled receptors: from signal transduction to signal integration , 1998, Oncogene.

[10]  N. Dhanasekaran,et al.  Regulation of cell proliferation by G proteins , 1998, Oncogene.

[11]  S. Soltoff.  Related Adhesion Focal Tyrosine Kinase and the Epidermal Growth Factor Receptor Mediate the Stimulation of Mitogen-activated Protein Kinase by the G-protein-coupled P2Y2 Receptor , 1998, The Journal of Biological Chemistry.

[12]  D Tripathy,et al.  Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[13]  T. Gudermann,et al.  Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Rhee,et al.  Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor* , 1998, The Journal of Biological Chemistry.

[15]  J. Turkson,et al.  Role of Tyrosine Kinase Activity of Epidermal Growth Factor Receptor in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Pathway* , 1998, The Journal of Biological Chemistry.

[16]  H. Kung,et al.  Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells , 1998, Nature.

[17]  L. Graves,et al.  Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G–protein coupled receptor–EGF receptor transactivation pathway , 1998, The EMBO journal.

[18]  H. Kawakatsu,et al.  Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells* , 1998, The Journal of Biological Chemistry.

[19]  S. Vaingankar,et al.  Thrombin Aivation of the 9E3/CEF4 Chemokine Involves Tyrosine Kinases Including c-src and the Epidermal Growth Factor Receptor* , 1998, The Journal of Biological Chemistry.

[20]  G. Schultz,et al.  The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho* , 1998, The Journal of Biological Chemistry.

[21]  D. Stern,et al.  Specificity within the EGF family/ErbB receptor family signaling network , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.

[22]  R. Lefkowitz,et al.  G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts , 1997, The Journal of Biological Chemistry.

[23]  A. Ullrich,et al.  Signal characteristics of G protein‐transactivated EGF receptor , 1997, The EMBO journal.

[24]  Kohjiro Ueki,et al.  Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone , 1997, Nature.

[25]  A. Ullrich,et al.  Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling* , 1997, The Journal of Biological Chemistry.

[26]  S. Hubbard.  Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog , 1997, The EMBO journal.

[27]  E. Peralta,et al.  The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity , 1997, The EMBO journal.

[28]  R. Lefkowitz,et al.  Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors , 1997, The Journal of Biological Chemistry.

[29]  N. Hynes,et al.  ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling , 1997, The EMBO journal.

[30]  H. Bourne,et al.  How receptors talk to trimeric G proteins. , 1997, Current opinion in cell biology.

[31]  R. Lefkowitz,et al.  Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. , 1997, The Journal of biological chemistry.

[32]  A. Wong,et al.  Subsets of Epidermal Growth Factor Receptors during Activation and Endocytosis* , 1997, The Journal of Biological Chemistry.

[33]  A. Ullrich,et al.  Novel mechanisms of RTK signal generation. , 1997, Current opinion in genetics & development.

[34]  S. Lev,et al.  A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation , 1996, Nature.

[35]  Y. Yarden,et al.  A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor , 1996, Molecular and cellular biology.

[36]  A. Ullrich,et al.  Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. , 1996, The EMBO journal.

[37]  E. Dmitrovsky,et al.  The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors. , 1996, Cytokine & growth factor reviews.

[38]  P G Pelicci,et al.  Not all Shc's roads lead to Ras. , 1996, Trends in biochemical sciences.

[39]  M. Kitajima,et al.  Further evidence for prognostic significance of epidermal growth factor receptor gene amplification in patients with esophageal squamous cell carcinoma. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[40]  A. Levitzki.  Targeting signal transduction for disease therapy. , 1996, Current opinion in cell biology.

[41]  E. Adamson,et al.  UV activates growth factor receptors via reactive oxygen intermediates , 1996, The Journal of cell biology.

[42]  J. Pouysségur,et al.  Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein‐coupled thrombin receptor. , 1996, The EMBO journal.

[43]  A. Levitzki,et al.  Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor , 1996, Nature.

[44]  A. Ullrich,et al.  Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors , 1996, Nature.

[45]  M. Greenberg,et al.  Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[46]  K. Rubin,et al.  Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors , 1996, The Journal of cell biology.

[47]  M. Greenberg,et al.  Ca2+-Dependent Routes to Ras: Mechanisms for Neuronal Survival, Differentiation, and Plasticity? , 1996, Neuron.

[48]  Y. Yarden,et al.  ErbB‐2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. , 1996, The EMBO journal.

[49]  L. Dorssers,et al.  Expression of estrogen, progesterone and epidermal growth factor receptors in primary and metastatic breast cancer , 1995, International journal of cancer.

[50]  N. Lydon,et al.  Src Phosphorylation of the Epidermal Growth Factor Receptor at Novel Sites Mediates Receptor Interaction with Src and P85α (*) , 1995, The Journal of Biological Chemistry.

[51]  A. Levitzki,et al.  Tyrosine kinase inhibition: an approach to drug development. , 1995, Science.

[52]  J. Baselga,et al.  Cooperative antiproliferative effects of 8-chloro-cyclic AMP and 528 anti-epidermal growth factor receptor monoclonal antibody on human cancer cells. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

[53]  F. M. Huennekens.  Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates. , 1994, Trends in biotechnology.

[54]  P. Seeburg,et al.  Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells , 1984, Nature.

[55]  A. Ullrich,et al.  Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences , 1984, Nature.

[56]  P. Carter,et al.  Anti-p185HER2 monoclonal antibodies: biological properties and potential for immunotherapy. , 1992, Cancer treatment and research.

[57]  J. Schlessinger,et al.  Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock. , 1989, Oncogene.