Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis

[1]  Charles N Serhan,et al.  Resolution of acute inflammation in the lung. , 2014, Annual review of physiology.

[2]  D. Davies,et al.  Epithelial injury and repair in airways diseases. , 2013, Chest.

[3]  Yoon-Keun Kim,et al.  CCN1 Secretion Induced by Cigarette Smoking Extracts Augments IL-8 Release from Bronchial Epithelial Cells , 2013, PloS one.

[4]  M. Goldberg,et al.  Bacterial Subversion of Host Innate Immune Pathways , 2013, Science.

[5]  Lei Sun,et al.  Dual role of interleukin‐10 in the regulation of respiratory syncitial virus (RSV)‐induced lung inflammation , 2013, Clinical and experimental immunology.

[6]  Bor-Chyuan Su,et al.  Extracellular matrix protein CCN1 regulates cardiomyocyte apoptosis in mice with stress-induced cardiac injury. , 2013, Cardiovascular research.

[7]  M. T. Shata,et al.  New perspectives of an old cytokine. , 2013, Inflammatory bowel diseases.

[8]  Seung Yong Park,et al.  Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway , 2013, Scientific Reports.

[9]  G. Washko,et al.  TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[10]  J. Kolls,et al.  Host defenses against bacterial lower respiratory tract infection. , 2012, Current opinion in immunology.

[11]  F. Martinon.  The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses , 2012, Microbes and Infection.

[12]  Kaiqiang Ji,et al.  Integrin alphavbeta6 is involved in measles protein-induced airway immune suppression. , 2012, Cytokine.

[13]  H. Kang,et al.  Protein Kinase C δ (PKCδ)-Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling Cascade Regulates Glycogen Synthase Kinase-3 (GSK-3) Inhibition-mediated Interleukin-10 (IL-10) Expression in Lipopolysaccharide (LPS)-induced Endotoxemia* , 2012, The Journal of Biological Chemistry.

[14]  D. Sheppard,et al.  The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. , 2012, The Journal of clinical investigation.

[15]  Lester F. Lau,et al.  Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets , 2011, Nature Reviews Drug Discovery.

[16]  W. Jiang,et al.  Pattern of expression of CCN family members Cyr61, CTGF and NOV in human acute and chronic wounds. , 2011, Experimental and therapeutic medicine.

[17]  S. Rutz,et al.  Regulation and functions of the IL-10 family of cytokines in inflammation and disease. , 2011, Annual review of immunology.

[18]  Don D. Sin,et al.  The airway epithelium: more than just a structural barrier , 2011, Therapeutic advances in respiratory disease.

[19]  L. Lau,et al.  The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing , 2010, Nature Cell Biology.

[20]  L. Lau,et al.  Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages , 2010, The Journal of Immunology.

[21]  Margarida Saraiva,et al.  The regulation of IL-10 production by immune cells , 2010, Nature Reviews Immunology.

[22]  C. Coopersmith,et al.  Characterization and Modulation of the Immunosuppressive Phase of Sepsis , 2010, Infection and Immunity.

[23]  M. O’Reilly,et al.  Hyperoxia augments ER-stress-induced cell death independent of BiP loss. , 2009, Free radical biology & medicine.

[24]  Hong-pyo Kim,et al.  Caveolin‐1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  Xia Zhang,et al.  Interleukin‐10: new perspectives on an old cytokine , 2008, Immunological reviews.

[26]  C. Pothoulakis,et al.  Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis. , 2008, The American journal of pathology.

[27]  D. Sheppard,et al.  Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. , 2008, The American journal of pathology.

[28]  T. Mcclanahan,et al.  TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology , 2007, Nature Immunology.

[29]  A. Krieg,et al.  Therapeutic potential of Toll-like receptor 9 activation , 2006, Nature Reviews Drug Discovery.

[30]  N. Hay,et al.  The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts , 2005, The Journal of cell biology.

[31]  M. Suga,et al.  The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice. , 2005, Journal of biochemistry.

[32]  Yang Jin,et al.  Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. , 2005, American journal of respiratory cell and molecular biology.

[33]  M. Cazzola,et al.  Inflammation – A New Therapeutic Target in Pneumonia , 2005, Respiration.

[34]  O. Woodman,et al.  Daidzein and 17β-Estradiol Enhance Nitric Oxide Synthase Activity Associated with an Increase in Calmodulin and a Decrease in Caveolin-1 , 2004, Journal of cardiovascular pharmacology.

[35]  M. Qureshi,et al.  IL-10 Modulates Host Responses and Lung Damage Induced by Pneumocystis carinii Infection1 , 2003, The Journal of Immunology.

[36]  Simon C Watkins,et al.  CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity , 2002, Molecular and Cellular Biology.

[37]  S. Akira,et al.  Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[38]  V. Hornung,et al.  Identification of CpG oligonucleotide sequences with high induction of IFN‐α/β in plasmacytoid dendritic cells , 2001 .

[39]  J. Adamski,et al.  5′ flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus , 2001, Molecular pathology : MP.

[40]  T. Standiford,et al.  Cytokine immunotherapy during bacterial pneumonia: from benchtop to bedside. , 2001, Seminars in respiratory infections.

[41]  J. Murphy-Ullrich,et al.  Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology , 2000 .

[42]  N. Kaminski,et al.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.

[43]  N. Kaminski,et al.  A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1 , 1999, Cell.

[44]  T. Standiford,et al.  IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense. , 1999, Journal of immunology.

[45]  E. Greenberg,et al.  Production of β-defensins by human airway epithelia , 1998 .

[46]  R. McIntyre,et al.  Pentoxifylline treatment attenuates pulmonary vasomotor dysfunction in acute lung injury. , 1997, The Journal of surgical research.

[47]  G. Weiner,et al.  Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. , 1997, Blood.

[48]  M. Lisanti,et al.  Phosphorylation of Caveolin by Src Tyrosine Kinases , 1996, The Journal of Biological Chemistry.

[49]  D. A. Clayton,et al.  Pervasive CpG suppression in animal mitochondrial genomes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Jenkins,et al.  Tumor necrosis factor. Alpha and beta subtypes appear in circulation during onset of sepsis-induced lung injury. , 1991, The American review of respiratory disease.

[51]  L. Old,et al.  Tumor necrosis factor (TNF). , 1985, Science.

[52]  K. Heeg,et al.  CpG DNA in the Prevention and Treatment of Infections , 2012, BioDrugs.

[53]  A. Segal,et al.  How neutrophils kill microbes. , 2005, Annual review of immunology.

[54]  A. Krieg,et al.  CpG motifs in bacterial DNA and their immune effects. , 2002, Annual review of immunology.

[55]  V. Hornung,et al.  Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. , 2001, European journal of immunology.

[56]  J. Murphy-Ullrich,et al.  Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. , 2000, Cytokine & growth factor reviews.

[57]  E. Greenberg,et al.  Production of beta-defensins by human airway epithelia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.