Youth with a sport-related knee injury exhibit significant and persistent knee-related quality of life deficits at 12-month follow-up compared to uninjured peers.

OBJECTIVE: Compare knee-related quality of life (QOL) between youth with and without an intra-articular, sport-related knee injury at baseline (≤4 months post-injury), 6-month, and 12-month follow-up and assess the association between clinical outcomes and knee-related QOL. DESIGN: Prospective cohort study METHODS: We recruited 86 injured and 64 uninjured youth (similar age, sex, sport). Knee-related QOL was assessed with the Knee injury and Osteoarthritis Outcome Score (KOOS) QOL subscale. Linear mixed models (95%CI; clustered on sex and sport) compared KOOS QOL between study groups over the study period, considering sex-based differences. We also explored the association of injury type [anterior cruciate ligament (ACL)/meniscus injury or other], knee extensor strength (dynamometry), moderate-to-vigorous physical activity (MVPA; accelerometer), intermittent knee pain (Intermittent and Constant Osteoarthritis Pain, ICOAP), and fear of re-injury (Tampa Scale for Kinesiophobia, TSK-17) with knee-related QOL. RESULTS: Participant median (range) age was 16.4 (10.9-20.1) years, 67% were female, and 56% of injuries were ACL ruptures. Injured participants had lower mean KOOS QOL scores at baseline (-61.05; 95%CI -67.56,-54.53), 6-month (-41.37; 95%CI -47.94,-34.80), and 12-month (-33.34; 95%CI -39.86,-26.82) follow-up, regardless of sex. Knee extensor strength (6- and 12-month follow-up), MVPA (12-month follow-up), and ICOAP (all timepoints) were associated with KOOS QOL in injured youth. Additionally, having an ACL/meniscus injury and higher TSK scores were associated with worse KOOS QOL in injured youth. CONCLUSION: Youth with a sport-related knee injury have significant, persistent knee-related QOL deficits at 12-month follow-up. Knee extensor strength, physical activity, pain, and fear of re-injury may contribute to knee-related QOL.

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